A5102857212- Growth Hormone and Insulin-like Growth Factors
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Pituitary Gland Disorders and Treatments
- Asthma and respiratory diseases
- SARS-CoV-2 detection and testing
- Adrenal and Paraganglionic Tumors
- Allergic Rhinitis and Sensitization
- Genetic Syndromes and Imprinting
- Long-Term Effects of COVID-19
- Lipid metabolism and disorders
- Gastroesophageal reflux and treatments
- Genomics and Chromatin Dynamics
- Diet and metabolism studies
- Eosinophilic Esophagitis
- Soil erosion and sediment transport
- Helicobacter pylori-related gastroenterology studies
- Respiratory and Cough-Related Research
- Genetic factors in colorectal cancer
- RNA modifications and cancer
- Soil Carbon and Nitrogen Dynamics
- Genetics and Neurodevelopmental Disorders
- TGF-β signaling in diseases
- Mycorrhizal Fungi and Plant Interactions
- Genomic variations and chromosomal abnormalities
Peking Union Medical College Hospital
2020-2024
National Health and Family Planning Commission
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2024
Ningbo University
2022-2024
Lishui Central Hospital
2024
The First Hospital of Changsha
2022-2024
Central South University
2023-2024
Second Affiliated Hospital of Zhejiang University
2024
Ningbo First Hospital
2020-2022
Xi'an Medical University
2022
Perturbation of the microbiome has numerous associations with phenotypes and progression in chronic airways disease. However, differences nasal asthma allergic rhinitis (AR) have not been defined. We examined whether would vary among different comorbidities AR that those may be associated severity asthma. Nasal lavage fluid was collected from 110 participants, including 20 healthy controls, 30 subjects AR, combined + AR. The Asthma Control Questionnaire (ACQ-7) used to evaluate control...
Abstract This study aimed to explore the effectiveness and safety of azvudine, nirmatrelvir/ritonavir, molnupiravir in adult patients with mild-to-moderate COVID-19. retrospective cohort included COVID-19 (asymptomatic, mild, common types) at First Hospital Changsha (Hunan Province, China) between March November 2022. Eligible were classified into or groups according antiviral agents they received. The outcomes times nucleic acid negative conversion (NANC). 157 treated azvudine (n = 66),...
Little research has explored the proteomic characteristics of nasal lavage fluid from asthmatic patients. This study aims to investigate whether differentially expressed proteins (DEPs) in can serve as a biomarker differentiate asthma patients healthy controls (HCs) and discern between individuals with well controlled poorly asthma.
Background and Aims: Although the minimally invasive endoscopic Stretta procedure is being increasingly used as an alternative strategy to manage gastroesophageal reflux disease (GERD), benefits of this have be further evaluated in clinical settings. This prospective observational study assessed short-term midterm outcomes associated with laparoscopic Toupet fundoplication (LTF) procedure. Patients Methods: From January 2011 2012, we allocated 80 patients LTF 85 Primary outcome measures,...
Clinical genetic evaluation has been demonstrated as an important tool to elucidate the causes of growth disorders. Genetic defects collagen formation (the collagenopathies) have reported be associated with short stature and skeletal dysplasias. Etiological diagnosis abnormality-related is challenging, less known about recombinant human hormone (rhGH) therapy.This a single-center cohort study which aims at exploring architecture short-stature children abnormalities evaluating frequency...
Asthma and allergic rhinitis (AR) are widely considered to be the most common chronic inflammatory disorders. This study was performed investigate clinical features, disease severity, upper airway inflammation among patients with asthma, AR, asthma comorbid AR. Blood nasal lavage fluid samples were collected from isolated (n = 23), AR 22), 22). Demographic data, symptom evaluation, spirometry obtained all subjects. The levels of interleukin (IL)-4, IL-5, IL-13, IL-17, IL-25, IL-33, S100...
Recently, side effects from Dopamine Receptor Agonist Drugs (DAs) in treating pituitary prolactinoma have raised widespread concern. This study explores the incidence and influencing factors of DAs-related Chinese patients.A cross-sectional was conducted. 51 patients treated with DAs, 12 or microadenoma without DAs treatment, 33 healthy controls were included. The Barratt impulsivity scale-11, Patient Health Questionnaire 9, ICD screening questionnaire all used to evaluate psychological...
Background Growth hormone (GH)/thyroid stimulating (TSH) cosecreting pituitary adenoma (PA) is an exceedingly rare kind of bihormonal neuroendocrine tumors (PitNETs). Its clinical characteristics have rarely been reported. Objectives This study aimed to summarize the and experience diagnosis treatment among patients with mixed GH/TSH PAs from a single center. Methods We retrospectively reviewed 2063 diagnosed GH-secreting admitted Peking Union Medical College Hospital between January 1 st ,...
Patients with adult growth hormone deficiency (AGHD) are at increased risk of metabolic syndrome. Metabolic profiles in AGHD patients have been insufficiently evaluated.This work aims to explore serum metabolite by metabolomics analysis and assess potential metabolites associated recombinant human (rhGH) treatment.Thirty-one 31 healthy controls were enrolled. Untargeted ultra-performance liquid chromatography-coupled mass spectroscopy was conducted all baseline during 12 months rhGH...
Somatotroph pituitary neuroendocrine tumours (PitNETs) are characterized by complex and variable biological behaviours with unpredictable patterns of growth invasiveness. The molecular mechanisms reliable predictors markers invasiveness remain unknown.Seventy-two acromegaly patients were consecutively enrolled. Data-independent acquisition-based proteomics ingenuity pathway analysis conducted between invasive noninvasive somatotroph PitNETs. expression selected biomarkers was verified in...
Abstract Background This study was performed to investigate clinical features of patients with severe SARS-CoV-2 pneumonia and identify risk factors for converting cases in those who had mild moderate diseases at the start pandemic China. Methods In this retrospective, multicenter cohort study, were included. Demographic data, symptoms, laboratory values, outcomes collected. Data compared between non-severe patients. Results 58 included final analysis. Compared cases, a longer: time recovery...
With the continuous generation of new variants severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), pressure epidemic prevention and control continues to increase in China. Omicron with stronger infectiousness, immune escape ability repeated infection spread many countries regions around world a short period time. China has also successively reported cases imported infections. This study aims understand epidemiological characteristics variant via analyzing patients Hunan Province,...
Background: Starting from early December 2019, cases of human infection with a novel coronavirus were identified in Wuhan, Hubei Province, China. It spreads rapidly to other cities and numerous countries. This study was performed investigate clinical features patients severe SARS-CoV-2 pneumonia identify risk factors for converting those who had mild moderate diseases. Methods: In this retrospective, multicenter cohort study, included Ningbo First Hospital Jingzhou Central Hospital....
Abstract Purpose : To report a case series of four patients with isolated growth hormone deficiency (IGHD) type I from two Chinese pedigrees and to elucidate phenotype-genotype correlation IGHD II GH1 gene alterations in the literature. Methods: Whole exome sequencing (WES) were performed literature review was conducted. Results Four presented extreme retardation (height -4.74 -6.50 SDS) undetectable peak (GH) during GH stimulating test. WES revealed novel homozygous nonsense mutation,...
Background: Actinidia eriantha Benth is a widely used natural product from Traditional Chinese Medicine in the Actinidiaceae family. However, its wild resources have been declining due to over-exploitation. It has become urgent investigate genetic diversity for conservation of A. eriantha, evaluate current species and discover strategies preservation. Methods: The internal transcribed spacer (ITS) was among within populations this species. Dnasp, PERMUT Arlequin 3.0 software were calculate...