A5075355578- Bone Metabolism and Diseases
- Parkinson's Disease Mechanisms and Treatments
- Mesenchymal stem cell research
- Neurotransmitter Receptor Influence on Behavior
- Tissue Engineering and Regenerative Medicine
- Magnesium Alloys: Properties and Applications
- Allergic Rhinitis and Sensitization
- Sinusitis and nasal conditions
- TGF-β signaling in diseases
- Neuroscience and Neuropharmacology Research
- Bone Tissue Engineering Materials
- Respiratory and Cough-Related Research
Stomatology Hospital
2023
Shanghai Jiao Tong University
2013-2023
Shanghai Ninth People's Hospital
2023
Shanghai Sixth People's Hospital
2022
Bone morphogenetic protein (BMP-2) has been approved by the FDA to promote bone regeneration, but uncertain osteogenic effect and dose-dependent side effects may occur. Osteoimmunomodulation plays an important role in growth factor-based osteogenesis. Here, we explored how proinflammatory signals affect potential of BMP-2. We observed that expression level local IL-1β did not increase with dose BMP-2 mouse osteogenesis model. A low could new formation, trigger release from M1 macrophages. As...
Abstract Although various new biomaterials have enriched the methods for peri-implant inflammation treatment, their efficacy is still debated, and secondary operations on implant area also caused pain patients. Recently, strategies that regulate macrophage polarization to prevent or even treat peri-implantitis attracted increasing attention. Here, we prepared a laser-drilled covered with metal organic framework-miR-27a agomir nanomembrane (L-MOF-agomir) implant, which could load sustain...
Abstract Background 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induces Parkinson’s disease (PD)-like neurodegeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc) via its oxidized product, 1-methyl-4-phenylpyridinium (MPP+), which is transported by dopamine (DA) transporter into DA nerve terminals. receptor subtype 3 (D3 receptor) participates neurotransmitter transport, gene regulation system, physiological accommodation G protein-coupled superfamily...
Abstract Purpose: Patients with chronic rhinosinusitis (CRS) often have sleep impairments, and this issue is closely related to obstructive apnea (OSA). However, research using objective examinations evaluate quality in inpatients CRS lacking. This study aimed explore the sleeping characteristics of without nasal polyps (CRSsNP) when comorbid OSA polysomnography (PSG). Methods: For cross-sectional, single-center study, we recruited 147 adult male diagnosed CRSsNP between March 2019 April...