A5027699897- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- SARS-CoV-2 detection and testing
- Tuberculosis Research and Epidemiology
- Biosensors and Analytical Detection
- Mycobacterium research and diagnosis
- HIV, Drug Use, Sexual Risk
- SARS-CoV-2 and COVID-19 Research
- Adolescent Sexual and Reproductive Health
- Pneumocystis jirovecii pneumonia detection and treatment
- Viral gastroenteritis research and epidemiology
- Global Health and Surgery
- COVID-19 Clinical Research Studies
- Biosimilars and Bioanalytical Methods
- Cancer Genomics and Diagnostics
- Pneumonia and Respiratory Infections
- Diagnosis and treatment of tuberculosis
- Advanced biosensing and bioanalysis techniques
- COVID-19 and Mental Health
- HIV-related health complications and treatments
- Vaccine Coverage and Hesitancy
- HIV/AIDS Impact and Responses
- Infectious Diseases and Tuberculosis
- Focus Groups and Qualitative Methods
University of Washington
2016-2025
National Taiwan University
2024
Program for Appropriate Technology in Health
2024
National Clinical Research
2016-2024
Academia Sinica
2024
University of Alberta
2024
Seattle University
2017-2023
Massachusetts General Hospital
2010-2021
Strategic Analysis (United States)
2020-2021
University of KwaZulu-Natal
2021
The LumiraDx severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigen test, which uses a high-sensitivity, microfluidic immunoassay to detect the nucleocapsid protein of SARS-CoV-2, was evaluated for diagnosing disease 2019 (COVID-19) in adults and children across point-of-care settings (NCT04557046). Two paired anterior nasal swabs or two nasopharyngeal were collected from each participant. Swabs tested by SARS-CoV-2 test compared with real-time polymerase chain reaction...
A unique four-plexed RT-LAMP test kit operated by health workers can provide faster, more sensitive results than laboratory tests.
Current pharmacologic adherence monitoring for antiretrovirals involves expensive, labor-intensive liquid chromatography/tandem mass spectrometry (LC-MS/MS)-based methods. Antibody-based assays can monitor and support in real time. We developed a tenofovir (TFV)-based immunoassay further validated it directly observed therapy (DOT) study.
The World Health Organization's (WHO) "End TB" strategy calls for development and implementation of novel tuberculosis (TB) diagnostics. Sputum-based diagnostics are challenging to implement often less sensitive in high-priority populations. Nonsputum, biomarker-based tests may facilitate TB testing at lower levels the healthcare system, accelerate treatment initiation, improve outcomes. We provide guidance on design diagnostic accuracy studies evaluating nonsputum, within context WHO's...
Since the site of human subjects research has public health, regulatory, ethical, economic, and social implications, we sought to determine global distribution migration clinical using an open-access trial registry.We obtained individual data including location sites, dates operation, funding source (United States government, pharmaceutical industry, or organization), study phase (1, 1/2, 2, 2/3, 3) from ClinicalTrials.gov. We used World Bank's classification each country's economic...
Testing for mycobacterial lipoarabinomannan (LAM) in urine is a practical but insensitive alternative to sputum testing diagnose tuberculosis (TB) people with HIV (PWH). Here, we evaluated LAM alongside PCR-based tests Mycobacterium (MTB) DNA tongue swabs.
Background In sub-Saharan Africa (SSA), adolescent girls and young women (AGYW) ages 15 to 24 years represent <10% of the population yet account for 1 in 5 new HIV infections. Although oral pre-exposure prophylaxis (PrEP) with tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) can be highly effective, low persistence PrEP programs poor adherence have limited its ability reduce incidence among women. Methods findings A total 336 AGYW participating PEPFAR-funded DREAMS program western...
Adolescents and young adults (AYA) living with HIV face several challenges to engaging in care, which can impact adherence antiretroviral therapy (ART). Point-of-care (POC) diagnostics that detect tenofovir urine may be a useful tool support ART adherence, but perspectives from AYA South Africa have not been explored. We conducted in-depth interviews (IDIs) among people (age 18-24) newly diagnosed Cape Town, focus group discussion (FGD) care providers understand their regarding the use of...
Nucleic acid amplification tests (NAATs) can achieve high accuracy for diagnosing infectious diseases by targeting conserved genetic sequences specific to the target organism. Isothermal NAATs, such as reverse-transcription loop mediated isothermal (RT-LAMP), simplify instrumentation requirements, facilitating point-of-care testing. However, sequence variation due variability cause false negative results. Single-pot multiplex testing improve coverage, but RT-LAMP is complicated requiring...
Abstract Background Tenofovir diphosphate concentration in red blood cells is an objective measure of long-term oral pre-exposure prophylaxis (PrEP) or antiretroviral therapy (ART) adherence. However, current methods for measuring tenofovir are equipment and capital intensive, limiting widespread adoption. Objectives Low cost, rapid diagnostics may drive clinical adoption routine drug level measurement as a tool adherence monitoring disoproxil fumarate-based PrEP ART. We validate simple...
Real-time, urine tenofovir testing may allow for clinic-based monitoring of adherence to antiretroviral therapy (ART). We aimed assess (1) the acceptability monthly point-of-care over first five months following ART initiation and (2) perspectives on implementation among people living with HIV (PLWH) healthcare providers participating in a randomized controlled trial which used test South Africa. conducted in-depth interviews 20 PLWH six-months post-ART eight providers. assessed (using...
Key stakeholders' involvement is crucial to the sustainability of quality point-of-care (POC) diagnostics services in low-and-middle income countries. The aim this study was explore key stakeholder perceptions on implementation POC rural primary healthcare (PHC) clinics South Africa.We conducted a qualitative encompassing in-depth interviews with multiple stakeholders diagnostic for and resource-limited PHC clinics. Interviews were digitally recorded transcribed verbatim prior thematic...
The Determined, Resilient, Empowered, AIDS-free, Mentored, and Safe (DREAMS) Initiative aims to reduce HIV infections among adolescent girls young women (AGYW) in Africa. Oral pre-exposure prophylaxis (PrEP) is offered through DREAMS Kenya eligible AGYW high burden counties including Kisumu Homa Bay. This study examines PrEP persistence community-based delivery settings. We evaluated the program Bay using survival analysis programmatic refill data collected between March December 2017. Among...
BackgroundSince mental health may influence HIV care among people living with (PLHIV), we sought to evaluate the impact of anxiety and depression on ART initiation HIV-related outcomes.MethodsWe conducted a prospective cohort study PLHIV in Umlazi Township KwaZulu-Natal, South Africa. We measured using Patient Health Questionnaire (PHQ-9) Generalized Anxiety Disorder (GAD-7) scale, both which have been validated sub-Saharan Africa, all patients prior receiving positive test. then followed...
The arrival of the next generation advanced diagnostic point-of-care tests was announced on July 28, 2015, when Cepheid and their non-profit partner, FIND, unveiled a new device called GeneXpert Omni.1Cepheid FINDWorld's most portable molecular diagnostics system at AACC.http://ir.cepheid.com/releasedetail.cfm?releaseid=924108Date: 2015Google Scholar Although this might seem to be yet another rapid nucleic acid amplification test, it is small (23 cm tall), lightweight (1 kg), easy use,...
Introduction Several supply chain components are important to sustain point-of-care (POC) testing services in rural settings. To evaluate the availability of POC diagnostic tests Ghana's primary healthcare (PHC) clinics, we conducted an audit management for Upper East Region's (UER) PHC Ghana determine reasons/causes deficiencies. Material and methods We a review accessible diagnostics 100 clinics UER, from February March 2018. used monitoring tool adopted World Health Organization...
Introduction Providing antiretroviral therapy (ART) for millions of people living with HIV requires efficient, client-centred models differentiated ART delivery. In South Africa, the Centralised Chronic Medication Dispensing and Distribution (CCMDD) programme allows over 1 million to collect chronic medication, including ART, from community pick-up points. We aimed explore how CCMDD influences engagement in care. Methods performed in-depth interviews focus group discussions clients receiving...