A5003157230- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Diagnosis and treatment of tuberculosis
- Infectious Diseases and Mycology
- Pneumocystis jirovecii pneumonia detection and treatment
- Infectious Diseases and Tuberculosis
- Pneumonia and Respiratory Infections
- Actinomycetales infections and treatment
- Radiomics and Machine Learning in Medical Imaging
- Bacillus and Francisella bacterial research
- Migration, Health and Trauma
- Fungal Infections and Studies
- Antibiotic Resistance in Bacteria
- COVID-19 diagnosis using AI
- Bacteriophages and microbial interactions
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Ocular Infections and Treatments
- Hepatitis Viruses Studies and Epidemiology
- Global Health and Surgery
- Immune responses and vaccinations
- Hepatitis B Virus Studies
- Infectious Disease Case Reports and Treatments
- Medical Device Sterilization and Disinfection
- Biosimilars and Bioanalytical Methods
- Liver Disease and Transplantation
International Organization for Migration
2011-2023
World Health Organization
2012-2020
World Health Organization Regional Office for Europe
2011
Queensland Health
2004-2008
International Union Against Tuberculosis and Lung Disease
2007
Prince Charles Hospital
2002-2006
Princess Alexandra Hospital
2002
Prince Charles Hospital
2002
Princess Alexandra Hospital
2002
National Guard Health Affairs
1997-1998
A clear understanding of the genetic basis antibiotic resistance in Mycobacterium tuberculosis is required to accelerate development rapid drug susceptibility testing methods based on sequence. Raw genotype–phenotype correlation data were extracted as part a comprehensive systematic review develop standardised analytical approach for interpreting associated mutations rifampicin, isoniazid, ofloxacin/levofloxacin, moxifloxacin, amikacin, kanamycin, capreomycin, streptomycin,...
BackgroundPyrazinamide and fluoroquinolones are essential antituberculosis drugs in new rifampicin-sparing regimens. However, little information about the extent of resistance to these at population level is available.MethodsIn a molecular epidemiology analysis, we used population-based surveys from Azerbaijan, Bangladesh, Belarus, Pakistan, South Africa investigate pyrazinamide among patients with tuberculosis. Resistance was assessed by gene sequencing detection resistance-conferring...
In many countries, regular monitoring of the emergence resistance to anti-tuberculosis drugs is hampered by limitations phenotypic testing for drug susceptibility. We therefore evaluated use genetic sequencing surveillance in tuberculosis.Population-level surveys were done hospitals and clinics seven countries (Azerbaijan, Bangladesh, Belarus, Pakistan, Philippines, South Africa, Ukraine) evaluate estimate Mycobacterium tuberculosis isolates rifampicin, isoniazid, ofloxacin, moxifloxacin,...
Drug-resistant tuberculosis poses a persistent public health threat. The ReSeqTB platform is collaborative, curated knowledgebase, designed to standardize and aggregate global Mycobacterium complex (MTBC) variant data from whole genome sequencing (WGS) with phenotypic drug susceptibility testing (DST) clinical data. We developed unified analysis pipeline (UVP) ( https://github.com/CPTR-ReSeqTB/UVP ) identify variants assign lineage MTBC sequence Stringent thresholds quality control measures...
The aim of this study was to independently evaluate the diagnostic accuracy three artificial intelligence (AI)-based computer aided detection (CAD) systems for detecting pulmonary tuberculosis (TB) on global migrants screening chest x-ray (CXR) cases when compared against both microbiological and radiological reference standards (MRS RadRS, respectively). Retrospective clinical data CXR images were collected from International Organization Migration (IOM) pre-migration health assessment TB...
The World Health Organization's (WHO) "End TB" strategy calls for development and implementation of novel tuberculosis (TB) diagnostics. Sputum-based diagnostics are challenging to implement often less sensitive in high-priority populations. Nonsputum, biomarker-based tests may facilitate TB testing at lower levels the healthcare system, accelerate treatment initiation, improve outcomes. We provide guidance on design diagnostic accuracy studies evaluating nonsputum, within context WHO's...
Abstract Approximately 3.6 million cases of active tuberculosis (TB) go potentially undiagnosed annually, partly due to limited access confirmatory diagnostic tests, such as molecular assays or mycobacterial culture, in community and primary healthcare settings. This article provides guidance for TB triage test evaluations. A is designed use people with symptoms and/or significant risk factors TB. Triage tests are simple low-cost aiming improve ease implementation (compared tests) decrease...
Purpose: To correlate the clinical presentation and treatment outcome of Nocardia keratitis with time to diagnosis, different species drug sensitivity pattern. Method: Patients corneal ulcers were studied at a tertiary eye care center. Speciation isolates was done by sequencing 16s rRNA gene. Clinical response assessed chart review. Results: Twenty one (65.3%) patients presented within 15 days onset symptoms typical features keratitis, ie, ring-like distribution superficial infiltrates in...
To record 17 cases of nocardiosis in cats from eastern Australia and to compare this series with previously reported.Retrospective/prospective study.Nocardia spp infections were diagnosed over 14 years the three states Australia. There no isolates dogs during period, but one isolate a koala two dairy cows. The majority presented spreading lesions subcutis skin associated draining sinus tract(s). Early cutaneous consisted circumscribed abscesses. Infections spread at variable rate, generally...
Novel accurate tests are needed that identify individuals infected with Mycobacterium tuberculosis who have incipient disease and likely to develop clinical (TB) in the near future allow for targeted preventive treatment beyond current risk groups. Recently, a target product profile was developed outlines minimal optimal characteristics such an TB test. We describe evaluation framework generating evidence inform development of policy guidance use new test by World Health Organization. Two...
Objective: To review patient outcomes and the molecular epidemiology of multidrug-resistant tuberculosis (MDR-TB) strains isolated from patients living in Western Province Papua New Guinea (PNG) seeking treatment Australia. Design, setting participants: Review all cases MDR-TB among people open border region between PNG Torres Strait Islands Australia who presented to health clinics 2000 2006. All suspected TB were bacteriologically confirmed at time presentation by Mycobacterium Reference...
Abstract Existing high-priority target product profiles (TPPs) of the World Health Organization (WHO) establish important needs for tuberculosis (TB) diagnostic development. Building on this earlier work, guidance series aims to provide study performing accuracy studies novel products that may meet 4 WHO TPPs and thus enable adequate evidence generation inform a review process. Diagnostic represent fundamental step in validation all tests. Unfortunately, such often have limitations design,...
Tests that can replace sputum smear microscopy have been identified as a top priority diagnostic need for tuberculosis by the World Health Organization. High-quality evidence on accuracy tests may meet this is an essential requirement to inform decisions about policy and scale-up. However, test studies are often of low inconsistent quality poorly reported, leading uncertainty true performance. Here we provide guidance design smear-replacement tests. Such should cross-sectional or cohort...
The recent launch of the new Xpert MTB/XDR assay (Cepheid Inc., Sunnyvale, CA, USA) by Foundation for Innovative New Diagnostics [1] was widely welcomed tuberculosis (TB) community, given critical need and better diagnostics to guide treatment drug resistant (DR-TB). detects resistance isoniazid (target genes: inhA promoter, katG , fabG1 oxyR-aphC intergenic region), ethionamide ( promoter), fluoroquinolones gyrA gyrB ), second-line injectables rrs eis promoter) is positioned as an add-on or...
Background: Few epidemiologic reports on the prevalence of hepatitis C in Saudi blood donors have been published. Study Design and Methods: Men (of several nationalities) donating at King Khalid National Guard Hospital (Jeddah, Arabia) were randomly selected (n = 744) for this study examining virus (HCV) local donor population, relationship antibody to HCV (anti‐HCV) surrogate markers alanine aminotransferase (ALT) B core antigen (anti‐HBc), effect use these discard rate. Results: The...
A knowledge, attitude, behaviour, and practice survey was conducted among labour migrants in Tajikistan to elucidate key factors influencing access tuberculosis diagnosis care both their destination country at home. 509 were interviewed Khaton Rasht Valley regions using a standardised questionnaire. In addition, in-depth interviews ten patients who had recently worked abroad. The study showed that have increased vulnerability due the working living conditions health services is limited legal...
Nine dogs with panniculitis due to rapidly growing mycobacteria (RGM) were examined over 17 years. Dogs two 15 years; five male, four female. All obese or in good condition. Antecedent injury, typically a dog bite vehicular trauma, could be identified some patients, while one bitch had hyperadrenocorticism. Infections involved different locations, although the cervicothoracic region, dorsum flank most often affected. Patients systemically well, apart from pyrexia and pain lameness. Cytology...
In industrialised countries, sufficient resources for establishing and maintaining fully equipped biosafety level 3 (BSL-3) laboratories according to international standards are generally available. BSL-3 designed provide several layers of containment protect the laboratory worker as well outside environment community from risk exposure in case local contamination. However, such facilities scarce high-burden settings, primarily due high financial burden complexity initial construction and/or...