A5062617618- Tuberculosis Research and Epidemiology
- Pneumonia and Respiratory Infections
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV/AIDS Research and Interventions
- Diagnosis and treatment of tuberculosis
- Adolescent Sexual and Reproductive Health
- HIV/AIDS Impact and Responses
- Poverty, Education, and Child Welfare
- Mycobacterium research and diagnosis
- Antibiotic Resistance in Bacteria
- Viral Infections and Outbreaks Research
- Chronic Disease Management Strategies
Office of Infectious Diseases
2014-2025
United States Agency for International Development
2014-2024
World Health Organization
2017
Netherlands Leprosy Relief
2017
Royal Tropical Institute
2017
Program for Appropriate Technology in Health
2009
Tulane University
2003
The estimated number of maternal deaths in 2013 worldwide was 289 000, a 45% reduction from 1990. Non-obstetric causes such as infectious diseases including tuberculosis now account for 28% deaths. In 2013, 3·3 million cases were to occur women globally. During pregnancy, is associated with poor outcomes, increased mortality both the neonate and pregnant woman. aim our study estimate burden disease among women, describe how care services could be used platform improve case detection.We...
In many countries, regular monitoring of the emergence resistance to anti-tuberculosis drugs is hampered by limitations phenotypic testing for drug susceptibility. We therefore evaluated use genetic sequencing surveillance in tuberculosis.Population-level surveys were done hospitals and clinics seven countries (Azerbaijan, Bangladesh, Belarus, Pakistan, Philippines, South Africa, Ukraine) evaluate estimate Mycobacterium tuberculosis isolates rifampicin, isoniazid, ofloxacin, moxifloxacin,...
In Tanzania, people with tuberculosis (TB) commonly self-medicate or visit traditional healers before seeking formal medical care. Between 2009 and 2011, we piloted a community-based project in Kisarawe District to improve TB case notification. The trained 15 pharmacists identify refer individuals symptoms diagnostic facilities. addition, the 2 community members collect fix sputum from symptomatic onto slides, which they then delivered by bicycle nearest facility. To determine effectiveness,...
Globally, the gap between number of children who develop TB and those are detected treated is narrowing, but it remains much wider than among adults. Several new diagnostic tests approaches have been implemented recently, more anticipated in development pipeline. We examine current tools prospects for testing propose a framework to guide national programs partners addressing treatment coverage while highlighting promising research programmatic interventions.
In 2020, fecal (stool) testing was recommended for diagnosing Mycobacterium tuberculosis complex (MTBC) infection in children by using the Cepheid Xpert MTB/RIF assay; since then, countries have begun implementing stool-based testing, often as part of a comprehensive strategy to enhance TB case finding among children. On basis an experience-sharing workshop November 2023, we determined insights 9 early-adopter countries. Across those countries, 71,757 underwent stool over combined period 121...
Crucial to finding and treating the 4 million tuberculosis (TB) patients currently missed by national TB programmes, stigma is receiving well-deserved long-delayed attention at global level. However, ability measure evaluate success of stigma-reduction efforts limited need for additional tools. At a 2016 stigma-measurement meeting held in The Hague, Netherlands, experts discussed proposed research agenda around four themes: 1) drivers: what are main drivers domains stigma(s)?; 2)...
<sec><title>BACKGROUND</title>We examined the feasibility of assessing and referring adults successfully completing TB treatment for comorbidities, risk determinants disability in health facilities Kenya, Uganda, Zambia Zimbabwe.</sec><sec><title>METHODS</title>This was a cross-sectional study within national programmes.</sec><sec><title>RESULTS</title>Health workers assessed 1,063 patients (78% eligible) median 22 min [IQR...
This study evaluates the impact of African Youth Alliance (AYA) program on sexual behavior young people aged 17–22 in Uganda. Between 2000 and 2005, comprehensive multicomponent AYA implemented behavior‐change communication youth‐friendly clinical services, it coordinated policy advocacy. The provided institutional capacity building established coordination mechanisms between agencies that programs for people. analysis findings from both a self‐reported exposure design static group...
Ambitious efforts to detect and treat tuberculosis (TB) are required reduce the burden of disease in low resource settings, provision high quality TB services is critical reaching global targets. The assessment (QTSA) a facility-based approach aimed at identifying gaps prioritizing interventions improve care across multiple countries with burden. Randomly sampled facilities assessed standardized instruments collect data on structures, processes, outcomes care, adaption for local diagnostic...
The potential gains from full adoption of World Health Organization (WHO)-recommended rapid diagnostics (WRDs) for tuberculosis (TB) are significant, but there is no current analysis the additional investment needed to reach this goal. We sought estimate necessary in instruments, tests, and money, using Xpert MTB/RIF (Xpert), which detects Mycobacterium (MTB) tests resistance rifampicin (RIF), as an example. An existing calculator TB diagnostic needs was adapted a group 24 countries with...