A5067368027- Immune Response and Inflammation
- Cancer Research and Treatments
- Neurological disorders and treatments
- Conducting polymers and applications
- Immune cells in cancer
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Circular RNAs in diseases
- Parkinson's Disease Mechanisms and Treatments
First Affiliated Hospital of Henan University
2019-2021
Background: Myeloid-derived suppressor cells (MDSCs) promote immunosuppression in the tumor microenvironment, support growth and survival, may contribute to immunotherapy resistance. Recent studies showed that tumor-derived exosomes (TDEs) can induce MDSCs accumulation expansion, mechanisms of which are largely unknown. Methods: The morphologies sizes was observed by using a JEM-1400 transmission electron microscope. MicroRNA(miR)-107 ARG1, DICER1, PTEN, PI3K, AKT, mTOR, NF-kB mRNAs were...
Myeloid-derived suppressor cells (MDSCs) are a group of heterogeneous derived from immature myeloid (IMCs). MDSCs known to play important roles in tumor immune evasion. While we know that there large number circulating and tumor-infiltrating existing gastric cancer (GC) patients, the phenotypic characteristics arginase 1 (ARG1) expression levels these remain very unclear. In our study, flow cytometric analysis 20 adenocarcinoma (GAC) patients found ≥80% ARG1-expressing were mainly...