A5100751502- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Breast Cancer Treatment Studies
- Cancer-related gene regulation
- DNA Repair Mechanisms
- Genetic factors in colorectal cancer
- BRCA gene mutations in cancer
- Cancer, Hypoxia, and Metabolism
- Global Cancer Incidence and Screening
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Liver physiology and pathology
- Hepatitis B Virus Studies
- Nutrition, Genetics, and Disease
- RNA Research and Splicing
- Hepatocellular Carcinoma Treatment and Prognosis
- Protein Tyrosine Phosphatases
- Breast Lesions and Carcinomas
- Nanoparticle-Based Drug Delivery
- Advanced Antenna and Metasurface Technologies
- Metamaterials and Metasurfaces Applications
- ATP Synthase and ATPases Research
- Cancer-related Molecular Pathways
- Cancer, Lipids, and Metabolism
Sichuan Cancer Hospital
2011-2024
University of Electronic Science and Technology of China
2019-2024
Central South University
2019
Third Xiangya Hospital
2019
Nanjing Medical University
2016
Jiangsu Province Hospital
2016
Zhejiang Provincial People's Hospital
2013
Second Military Medical University
2003-2013
Southern Medical University
2012
Eastern Hepatobiliary Surgery Hospital
2003
Abstract We previously established a rat model of diabetic cardiomyopathy (DCM) and found that the expression lncRNA H19 was significantly downregulated. The present study designed to investigate pathogenic role in development DCM. Overexpression rats attenuated oxidative stress, inflammation apoptosis, consequently improved left ventricular function. High glucose associated with reduced increased cardiomyocyte apoptosis. To explore molecular mechanisms involved, we performed vitro...
The aim of this study was to obtain adriamycin-loaded polymer-lipid hybrid nanoparticles conjugated with anti-EGF receptor antibody (PLNP-Mal-EGFR) for hepatocellular carcinoma (HCC) chemotherapy.The were characterized by dynamic light scattering and fluorescence spectroscopy. in vitro vivo distribution anti-tumor activity the evaluated.PLNP-Mal-EGFR showed significantly enhanced cellular cytotoxicity against HCC cells overexpressing EGFR compared nontargeted (polymer-lipid [containing...
Abstract Triple-negative breast cancer (TNBC) is a subtype of aggressive with high recurrence and poor survival. Emerging evidence has indicated that long non-coding RNAs (lncRNAs) play pivotal roles in the development progression multiple cancers. Although there are substantial studies revealing lung cancer-associated transcript 1 (LUCAT1) functions as tumor promotor various human cancers, molecular mechanism LUCAT1 TNBC remains largely to be explored. In our study, we identified expression...
Objective: The aim of the study was to estimate breast cancer risk conferred by individual single-nucleotide polymorphisms susceptibility genes. Methods: We analyzed 48 tagging 8 genes involved in monoubiquitinated FANCD2–DNA damage repair pathway 734 Chinese women with and 672 age-matched healthy controls. Results: Forty-five were successfully genotyped SNPscan, call rates for each above 98.9%. found that 13 5 ( Parter localizer Breast gene2 PALB2), Tumour protein 53 TP53), Nijmegen...
The aim of the present study was to analyze expression DNA-binding protein inhibitor 2 (ID2) in nasopharyngeal carcinoma (NPC) and its correlation with clinicopathological features. It found that ID2 significantly increased NPC cells when compared NP69 cell line. Similar level cytoplasmic observed non-cancerous nasopharynx tissues. However, nucleus normal Furthermore, higher nuclear associated tumor size (T classification), lymph node metastasis (N clinical stage. Patients had poorer overall...
Prior studies have demonstrated that phosphatase of regenerating liver-3 (PRL-3) serves avital function in cell proliferation and metastasis breast cancer. However, the molecular mechanisms underlying PRL-3 cancer remain unknown. expression was analyzed 24 pairs normal tissues using reverse transcription-quantitative polymerase chain reaction assay. The results present study identified PLR-3 increased 4.2-fold, compared with tissues. Notably, overexpression significantly promoted cells...
To explore the role of long non-coding RNA (lncRNA) X inactive specific transcript (XIST) in modulating cisplatin (DDP) resistance human nasopharyngeal carcinoma cells and investigate possible mechanism.Realtime PCR was performed to detect expression XIST cisplatin-resistant cell line HNE1/DDP. The effects up-regulation down-regulation on DDP resistance, proliferation apoptosis HNE1/ were assessed using MTT assay, EdU assay flow cytometry. Western blotting used changes expressions programmed...
Background: Patient delay commonly appears in breast cancer (BC), but the findings for influential factors may be contaminated by recall bias. The real patient (divided into appraisal and utilization delay) women with BC urgently need to objectively analyzed preventing progression of this disease.Methods: Women meeting strict inclusion exclusion criteria were asked fill a questionnaire, which included three sections sociodemographic characteristics, medical history, knowledge BC. Later on,...
We are concerned with the numerical simulation of metasurfaces modeled by generalized sheet transition conditions (GSTCs). A hybridizable discontinuous Galerkin (HDG) method is pro-posed to treat field discontinuity on metasurface. briefly recall mathematical expressions surface susceptibility tensors and present formulations HDG method. The examples simulating monoanisotropic metasurface show that proposed can easily adapt discontinuities caused GSTCs. Additionally, we COMSOL results for...
Abstract Background In patients with the HR+/HER2+ breast cancer (BC) subtype, it can be more challenging to achieve pathological complete response (pCR) after neoadjuvant therapy compared HR-/HER2+ subtype. The importance of and association pCR long-term clinical benefits have been widely demonstrated in HER2+ BC. This network meta-analysis aimed identify optimal anti-HER2 regimen, role endocrine therapy, better chemotherapy choice for treatment BC patients. Methods Literature trials was...
Hepatocellular carcinoma (HCC) is one of the most frequent malignancies in numerous countries. The incidence HCC rapidly increasing andp ] proximately results 350,000 deaths each year worldwide (1-4). conventional chemotherapy and radiation treatment for have been disappointing, with an overall 5-yr survival rate less than 5%. Although surgical excision considered effective therapy early-stage patients, only a very small proportion patients operable primary lesion may transiently benefit...
Objective To screen the radiation-resistant and radiation-sensitive cell strains from 5 colorectal cancer lines observe muitidrug resistance-associated proteins 4 (MRP4) protein expression in two lines,and explore relashionship between MRP4 radiation sensitivity.Methods Different doses (0,2,4,6 8 Gy) were used to irradiate colonrectal LOVO,DLD-1,HT-29,HCT116 RKO,and sensitive resistant screened.Immunohistochemistry was detect these lines.Results Radiation LOVO RKO separately.Their growth...
Objective To analyze the role of postmastectomy radiotherapy in different molecular subtypes breast cancer patients with Stage T1 -T2 and one to three positive axillary nodes. Methods A total 436 lymph nodes treated mastectomy dissection were retrospectively analyzed. Patients grouped as following four subtypes:Luminal A, Luminal B, Her2+ triple-negative. The local recurrence (LR), distant metastasis ( DM ), disease free survival (DFS) overall (OS) rates compared between paitents or without...