A5026105325- Reproductive System and Pregnancy
- Gynecological conditions and treatments
- Endometriosis Research and Treatment
- Pregnancy and preeclampsia studies
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Ovarian function and disorders
- Endometrial and Cervical Cancer Treatments
- Glycosylation and Glycoproteins Research
- Blood Coagulation and Thrombosis Mechanisms
- Advanced biosensing and bioanalysis techniques
- Radiopharmaceutical Chemistry and Applications
- Reproductive Biology and Fertility
- Urinary Tract Infections Management
- Reproductive tract infections research
- Uterine Myomas and Treatments
- Monoclonal and Polyclonal Antibodies Research
Shanghai First Maternity and Infant Hospital
2021-2023
Conventional antibody-based targeted cancer therapy is one of the most promising avenues successful treatment, with potential to reduce toxic side effects healthy cells surrounding tumor cells. However, full antibodies severely limited due their large size, low stability, slow clearance, and high immunogenicity. Alternatively, recently discovered nanobodies, which are smallest naturally occurring antigen-binding format, have shown great for addressing these limitations. Bioconjugation...
Abstract The cause for at least 50% of recurrent miscarriages is unclear, which defined as unexplained miscarriages. B7-H1 (PD-L1), a molecule the B7 family, promotes tumor development by modulating immune evasion, and recent researchers have also attached importance to role B7-H3, another in tumor. Based on similarity between growth response tumors pregnancy, we first explored B7-H3 We found reduced levels villus tissue miscarriage patients, it was mainly expressed cell membrane...
Although Epirubicin (EPI) is a commonly used anthracycline for the treatment of breast cancer in clinic, serious side effects limit its long-term administration including myelosuppression and cardiomyopathy. Nanomedicines have been widely utilized as drug delivery vehicles to achieve precise targeting cells. Herein, we prepared DSPE-PEG nanocarrier conjugated peptide, which targeted overexpression protein Na+/K+ ATPase α1 (NKA-α1). The encapsulated EPI grafted with NKA-α1 peptide through...
Premature ovarian failure (POF) and intrauterine adhesion (IUA) that easily lead to reduced fertility in premenopausal women are two difficult diseases treat obstetrics gynecology. Hormone therapy, vitro fertilization surgical treatments do not completely restore fertility. The advent of hydrogels offers new hope for the treatment POF IUA. Hydrogels noncytotoxic biodegradable, cause immune rejection or inflammatory reactions. Drug delivery stem cell main application forms. a local drug...
Recurrent miscarriage (RM) seriously affects the physical and mental health of women childbearing age, 50% causes are unknown. Thus, it is valuable to investigate unexplained recurrent (uRM). Similarities between tumor development embryo implantation make us realize that studies informative for uRM. The non-catalytic region tyrosine kinase adaptor protein 1 (NCK1) highly expressed in some tumors, can promote growth, invasion migration. In this present paper, we firstly explore role NCK1 We...