Sanyang Liu
A5101706554- Genomics and Phylogenetic Studies
- Genetic diversity and population structure
- Bat Biology and Ecology Studies
- Physiological and biochemical adaptations
- Genetic Mapping and Diversity in Plants and Animals
- Machine Learning in Bioinformatics
- Animal Diversity and Health Studies
- Genomics and Rare Diseases
- Molecular Biology Techniques and Applications
- Cancer Genomics and Diagnostics
- Wheat and Barley Genetics and Pathology
- CRISPR and Genetic Engineering
- Fuzzy Systems and Optimization
- Evolution and Paleontology Studies
- Chromosomal and Genetic Variations
- Economic and Industrial Development
- Mitochondrial Function and Pathology
- Bioinformatics and Genomic Networks
- Plant Virus Research Studies
- Education, Innovation and Language Studies
- Fractal and DNA sequence analysis
- Enzyme Production and Characterization
- Identification and Quantification in Food
- Gene expression and cancer classification
- Animal Genetics and Reproduction
Annoroad Gene Technology (China)
2019-2022
BGI Group (China)
2013-2014
Xidian University
2012
Tigers and their close relatives (Panthera) are some of the world's most endangered species. Here we report de novo assembly an Amur tiger whole-genome sequence as well genomic sequences a white Bengal tiger, African lion, lion snow leopard. Through comparative genetic analyses these genomes, find signatures that may reflect molecular adaptations consistent with big cats' hypercarnivorous diet muscle strength. We leopard-specific determinant in EGLN1 (Met39>Lys39), which is likely to be...
The importance of structural variants (SVs) for human phenotypes and diseases is now recognized. Although a variety SV detection platforms strategies that vary in sensitivity specificity have been developed, few benchmarking procedures are available to confidently assess their performances biological clinical research. To facilitate the validation application these approaches, we established an Asian reference material by characterizing genome Epstein-Barr virus (EBV)-immortalized B...
Abstract The importance of structural variants (SVs) on phenotypes and human diseases is now recognized. Although a variety SV detection platforms strategies that vary in sensitivity specificity have been developed, few benchmarking procedures are available to confidently assess their performances biological clinical research. To facilitate the validation application those approaches, our work established an Asian reference material comprising identified benchmark regions high-confidence...
Abstract Background Trachypithecus leucocephalus , the white-headed langur, is a critically endangered primate that endemic to karst mountains in southern Guangxi province of China. Studying genomic and transcriptomic mechanisms underlying its local adaptation could help explain persistence within highly specialized ecological niche. Results In this study, we used PacBio sequencing optical assembly Hi-C analysis create high-quality de novo T. genome. Annotation functional enrichment revealed...
Abstract Bread wheat expanded its habitats from a small core area of the Fertile Crescent to global environments within ∼10,000 years. Genetic mechanisms this remarkable evolutionary success are not well understood. By whole-genome sequencing populations 25 subspecies genera Triticum and Aegilops , we identified composite introgression these wild contributing 13%∼36% bread genome, which tremendously increased genetic diversity allowed divergent adaptation. Meanwhile, convergent adaption...
Abstract Sequencing technologies have been rapidly developed recently, leading to the breakthrough of sequencing-based clinical diagnosis, but accurate and complete genome variation benchmark would be required for further assessment precision medicine applications. Despite human cell line NA12878 has successfully a benchmark, population-specific is still lacking. Here, we established an Asian by constructing sequencing stabilized Chinese Han volunteer. By using seven different strategies,...
Abstract Precision medicine of human requires an accurate and complete reference variant benchmark for different populations. A standard cell line NA12878 provides a good part the populations, but it is still lack fine sample Asians. Here, we constructed stabilized Chinese Han volunteer. We received about 4.16T clean data using eight sequencing strategies in laboratories, including two BGI regular NGS platforms, three Illumina linked-read libraries, PacBio CCS model. The depth coverage have...