A5107700242- Renal and related cancers
- Neural Networks Stability and Synchronization
- Cancer Immunotherapy and Biomarkers
- Genetic factors in colorectal cancer
- Renal cell carcinoma treatment
- Colorectal Cancer Treatments and Studies
- Neural Networks and Applications
- Stability and Controllability of Differential Equations
- Immune Cell Function and Interaction
- Gene Regulatory Network Analysis
- Bioinformatics and Genomic Networks
- Stability and Control of Uncertain Systems
- Acute Lymphoblastic Leukemia research
- Natural product bioactivities and synthesis
- Epigenetics and DNA Methylation
- Plant biochemistry and biosynthesis
- Parathyroid Disorders and Treatments
- RNA modifications and cancer
- Genetic and Kidney Cyst Diseases
- Cancer Cells and Metastasis
- Immune cells in cancer
- Cancer Mechanisms and Therapy
- Peatlands and Wetlands Ecology
- Control and Stability of Dynamical Systems
- Plant Molecular Biology Research
Umeå University
2013-2024
Hebei Agricultural University
2023-2024
South China University of Technology
2024
Shanghai Electric (China)
2024
Lu'an First People's Hospital
2024
Henan University of Science and Technology
2020-2022
First Affiliated Hospital of Soochow University
2015
Osaka University
2015
Nanjing Medical University
2015
Jiangsu Province Hospital
2015
The anti-tumor immune response has been shown to be of great prognostic importance in colorectal cancer (CRC) and so the tumors ability for evasion. Our aim this study was investigate tumor factors that influence immunity. We used a gene expression array search potential mechanisms escape.One candidate identified TAP1, involved antigen presentation by MHC class I. TAP1 protein evaluated immunohistochemistry 436 CRC patients Colorectal Cancer Umeå Study cohort. found significant association...
Colorectal cancer (CRC) is a heterogeneous disease, with varying clinical presentations and patient prognosis. Different molecular subgroups of CRC should be treated differently therefore, must better characterized. Organoid culture has recently been suggested as good model to reflect the nature CRC. However, organoid cultures cannot established from all tumors. The study examines which tumors are more likely generate organoids thus benefit ex vivo drug testing. Long-term 22 out 40 tumor...
The importance of the tumour microbiome in different aspects colorectal cancer (CRC) has been increasingly recognised, but many questions remain. aim this study was to explore effect specific CRC associated microbes on immune response, which a considerable prognostic value CRC. We applied qPCR detect Parvimonas micra and Fusobacterium nucleatum tissues from an immunologically well-characterised cohort 69 patients. This included detailed analyses profiles based flow cytometry transcriptomics...
Abstract Background The immune response has important clinical value in colorectal cancer (CRC) both prognosis and to immunotherapy. This study aims explore tumour cell infiltration relation clinically well-established molecular markers of CRC. Methods Multiplex immunohistochemistry multispectral imaging was used evaluate cytotoxic T cells (CD8 + ), Th1 (T-bet regulatory (FoxP3 B (CD20 macrophages (CD68 ) a cohort 257 CRC patients. Results We found the expected association between higher...
Background: A novel link between oncogenic KRAS signalling and WT1 was recently identified. We sought to investigate the role of in proliferation apoptosis. Methods: mutations (cMyc) expression were detected using Sanger sequencing real-time PCR 77 patients with non-small cell lung cancer (NSCLC). Overexpression knockdown generated plasmid siRNA via transient transfection technology H1299 H1568 cells. MTT assay for detection proliferation, TUNEL proteomic profiler apoptosis evaluation...
Dendrobium catenatum Lindl (Orchidaceae) has high medicinal and economic value. Unfortunately, industrially-cultivated D. exhibits inferior quality in comparison with wild-harvested plant materials. Previously, we produced tetraploid germplasm order to increase the production of bioactive compounds. However, although contains a higher polysaccharide content than diploid catenatum, molecular mechanism is still unknown. In this study, stems leaves was studied alongside comprehensive...
Wilms tumor gene 1 (WT1) expression has been suggested as an applicable minimal residual disease marker in acute myeloid leukemia (AML). We evaluated the use of this 43 adult AML patients. Quantitative assessment WT1 transcripts was performed using real-time quantitative-polymerase chain reaction assay. Samples from both peripheral blood and bone marrow were analyzed at diagnosis during follow-up. A strong correlation observed between normalized with 2 different control genes (β-actin ABL1,...
Colorectal cancer (CRC) is a heterogeneous disease with different genetic and molecular backgrounds, leading to diverse patient prognosis treatment response. Four consensus subtypes (CMS 1–4) have recently been proposed based on transcriptome profiling. A clinically practical immunohistochemistry (IHC) CMS classifier consisting of the four markers FRMD6, ZEB1, HTR2B, CDX2 was then demonstrated. However, IHC-CMS did not distinguish between CMS2 CMS3 tumours. In this study, we applied...
In this paper, state observation of coupled reaction-diffusion genetic regulatory networks (GRNs) with time-varying delays is investigated under Dirichlet boundary conditions. First, the above GRNs are constructed to model gene properties, where feedback regulation function assumed exhibit Hill form and a novel method deal it introduced. Then time-space sampled-data observer designed for mentioned new criteria established by utilizing Lyapunov stability theory inequality techniques Halanay...
Wilms' tumor gene 1 (WT1) can act as a suppressor or activator of tumourigenesis in different types human malignancies. The role WT1 squamous cell carcinoma the head and neck (SCCHN) is not clear. Overexpression has been reported SCCHN, suggesting possible oncogenic for WT1. In present study we aimed at investigating function its previously identified protein partners p63 p53 SCCHN line FaDu.Silencing RNA (siRNA) technology was applied to knockdown WT1, FaDu cells. Cell proliferation...
Abstract Ovarian carcinoma ( OC ) has a poor prognosis and lack early effective screening markers. Wilm's tumor gene 1 WT is overexpressed in s. Therefore, it of great interest to investigate whether 1‐specific antibody (Ab) measurements plasma can serve as biomarker anti‐ response, importance relation patient prognosis. Peripheral blood samples were obtained from total 103 women with ovarian tumors median being day (range 0–48 days) before operation. IgG Ab levels evaluated using...
A swarm-exploring neurodynamic network (SENN) based on a two-timescale model is proposed in this study for solving nonconvex nonlinear programming problems. First, by using convergent-differential neural (CDNN) as local quadratic (QP) solver and combining it with design method, (TTCD) exploited, its stability analyzed described detail. Second, swarm exploration neurodynamics are incorporated into the TTCD to obtain an SENN global search capabilities. Finally, feasibility of demonstrated via...
In this paper, we focus on the cluster synchronization of reaction-diffusion genetic regulatory networks (RDGRNs) with time-varying delays, where state system is not only time-dependent but also spatially-dependent due to presence terms. First, construct an intermittent space-dividing controller that effectively combines two control strategies, making it more cost-effective. Furthermore, based activation function division approach, propose a regulation method can improve delay upper bound...
The local anti-tumour immune response has important prognostic value in colorectal cancer (CRC). In the era of immunotherapy, a better understanding molecular subgroups CRC may lead to significant advances personalised medicine. On this note, microsatellite instable (MSI) tumours have been characterised by increased infiltration, suggesting MSI as marker for inhibitor checkpoint therapy. Here, we used flow cytometry perform comprehensive analysis activity profiles tumour tissues, adjacent...
The Wilms' tumour gene 1 (WT1) single nucleotide polymorphism (SNP) rs16754 has recently been described as an independent prognostic factor in acute myeloid leukaemia (AML) patients. It is of great interest to test whether WT1 SNPs can be used a molecular marker other cancer types order improve risk and treatment stratification. We performed sequencing analysis on all 10 exons the total 182 patients with clear cell renal carcinoma (ccRCC). Six different were identified, descending for minor...
The synchronization of reaction-diffusion neural networks with state and spatial couplings is investigated in this article, the time-varying delay stochastic disturbances are considered proposed systems. Due to development merits digital controllers, sampled-data control a natural choice establish continuous-time Here, we suggest controller design, where (in space) measurements taken finite number fixed sampling points domain. It assumed that intervals space bounded. Based on Lyapunov...
This work mainly concentrates on the state estimation for Markov jump coupled neural networks (MJCNNs) with reaction-diffusion terms, in which memory controller is employed. First, considered MJCNNs model introduced, and dynamic error system can be obtained based proposed estimator. Then, a that involves constant signal transmission delay designed. Moreover, by Lyapunov functional method, inequality technique Kronecker product law, novel stable extended dissipative analysis criteria...
Lung cancer is considered the most ubiquitous malignant form of cancer, and current treatment strategies do not offer effective outcomes to patients. The present study examined effectiveness natural drugs delphinidin (DN) oroxylin A (OA) in inhibiting development lung cells (A549) through blocking Signal transducer activator transcription 3 (STAT3) focal adhesion kinase (FAK) intervene signaling pathways. These included cytotoxicity assessments, reactive oxygen species (ROS) levels,...
Abstract The systemic inflammatory response (SIR), defined as elevated levels of circulating C-reactive protein (CRP), is an important predictor impaired survival in colorectal cancer. aim this study was to explore the prognostic role SIR and its association with tumour mismatch repair status immune response. Immune activity profiles mononuclear cells isolated from CRC tissues blood U-CAN exploration cohort ( n = 69), were analysed by flow cytometry. In validation 257), T-helper (T-bet + ),...