Abstract Background Enhanced recovery after surgery (ERAS) protocols were rapidly adopted in many surgeries such as fast-track arthroplasty. The study aimed to investigate the impact of ERAS on clinical effect total knee arthroplasty (TKA) via midvastus approach. Methods A 69 patients who underwent primary unilateral TKA approach from October 2018 June 2019 enrolled and randomly divided into two groups: group Control group. for consisted pure juice drinking 2 h before surgery, optimization...

Purpose: This study aims to investigate the impact of enhancing subchondral bone repair on efficacy articular cartilage restoration, thereby achieving improved osteochondral regeneration outcomes. Methods: In this study, we modified surface nano-hydroxyapatite (n-HAp) through alkylation reactions prepare n-HApMA. Characterization techniques, including X-ray diffraction, infrared spectroscopy scanning, thermogravimetric analysis, particle size and electron microscopy, were employed analyze...

Chinese herbal medicine Fructus Cnidii has an outstanding effect on chronic lumbar pain and impotence, also been used against osteoporosis with high frequency. Yet, the mechanisms of osthole, a derivative Cnidii, osteoclasts remains barely known. In this study, it was found out that osthole (10-6 mol/L, 10-5 mol/L) had influence inhibiting osteoclast formation bone resorptive activities induced by receptor activator nuclear factor κB ligand (RANKL), rather than affecting viability...

Osthole (OST), a derivative of Fructus Cnidii, has been proved to have potential anti-osteoporosis effects in our recent studies. However, its pharmacological are limited the human body because poor solubility and bioavailability. Under guidance classical theory Chinese medicine, Osthole-loaded N-octyl-O-sulfonyl chitosan micelles (NSC-OST), which not previously reported literature, was synthesized order overcome defects obtain better efficacy. In this study, we found that NSC-OST inhibited...

The Chinese medicine compound, Jisuikang, can promote recovery of neurological function by inhibiting lipid peroxidation, scavenging oxygen free radicals, and effectively improving the local microenvironment after spinal cord injury. However, mechanism remains unclear. Thus, we established a rat model acute injury using modified version Allen's method. Jisuikang (50, 25, 12.5 g/kg/d) prednisolone were administered 30 minutes anesthesia. Basso, Beattie, Bresnahan locomotor scale scores...

Purpose: This study aims to explore a novel scaffold for osteotendinous junction regeneration and preliminarily verify its osteogenic tenogenic abilities in vitro.Methods: A polycaprolactone (PCL) with aligned orthogonal fibers was created using melt electrowriting (MEW) fused deposition modeling (FDM).The coated Type I collagen, hydroxyapatite carefully added separate the regions intended bone tendon regeneration, before being rolled into cylindrical shape.Human adipose-derived stem cells...

To observe the efficacy and safety of Shaoyang Xibi decoction (SYXBD) in patients with knee osteoarthritis (KOA), to verify that theory "Shaoyang dominating bone" Traditional Chinese Medicine (TCM) can be applied KOA treatment. Participants were randomly allocated two groups: SYXBD (treatment group, n = 66) Meloxicam (control 66). Western Ontario McMaster Universities Osteoarthritis Index (WOMAC) 36-Item Short Form Health Survey (SF-36) used assess before treatment 8 weeks after Baseline...

Jisuikang (JSK) is an herbal formula composed of many kinds traditional Chinese medicine, which has been proved to be effective in promoting the rehabilitation patients with spinal cord injury (SCI) after more than ten years clinical application. However, mechanisms JSK nerve regeneration are yet clarified. The aim this study was investigate effects protecting neurons, specifically regulation NgR/RhoA/ROCK signal pathway. motor function rats evaluated by BBB score and inclined plate test,...

Pharmacognosy Magazine,2018,14,58,641-646.DOI:10.4103/pm.pm_591_17Published:November 2018Type:Original ArticleAuthors:Suyang Zheng, Yong Ma, Yang Guo, Lining Wang, and Yalan Pan Author(s) affiliations:Suyang Zheng1, Ma2, Guo1, Wang1, Pan1 1 Laboratory of New Techniques Restoration Reconstruction Orthopedics Traumatology, Institute Traumatology Orthopedics, Nanjing University Chinese Medicine, 210029, China 2 Medicine; Department Affiliated Hospital Abstract:Background: Osthole is extracted...

The blood-spinal cord barrier (BSCB) changes badly after spinal injury (SCI), and it is an important pathophysiological basis of SCI secondary damage. Aquaporin-4 (AQP4), one the transmembrane proteins in cord, has been shown to be closely related development BSCB edema. We established a model rats using free-falling weight drop device subsequently investigate AQP4 expression. messenger RNA (mRNA) protein expression immunoreactivity were detected tissue reverse transcription-real-time...

Abstract Background Endoplasmic reticulum stress (ERS) is one of the main mechanisms spinal cord injury (SCI) pathology and can affect physiological state neurons. Icariin (ICA), pharmacological component Epimedium, relieve symptoms patients with SCI has obvious protective effects on neurons through ERS. Methods PC12 cells were induced to differentiate into by nerve growth factor identified flow cytometry. Cell proliferation was detected CCK8 method, cell viability SRB assay, apoptosis...

At present, the health risk assessment of cadmium exposure has become a major focus environmental research. However, there is still lack systematic research on burden diabetes (DM) attributable to dietary in adolescents and adults China. Using top-down method, blood level (B-Cd) Chinese from 2001 2023 was combined with relative (RR) cadmium-induced calculate population attribution score (PAF). Subsequently, PAF used assess disease (DB) caused by exposure, expressed disability adjusted life...

Osteoclasts are large, multinucleated, and bone-resorbing cells of the monocyte-macrophage lineage that formed by fusion monocytes or macrophage precursors. Excessive bone resorption is one most significant cellular mechanisms leading to osteolytic diseases, including osteoporosis, periodontitis, periprosthetic osteolysis. The main physiological function osteoclasts absorb both hydroxyapatite mineral component organic matrix bone, generating characteristic appearance on surface bones. There...

Acupuncture has been proved effective for cancer related pain (CRP) in China, America and some other countries. However, there is relative lack of evidence to support the use acupuncture CRP Australia.To assess effectiveness safety management a real-world setting understand patients' experience undergoing CRP.A pragmatic randomised controlled trial will be conducted South Western Sydney Local Health District (SWSLHD) NSW, Australia. Adults with (n = 106) 1:1 ratio receive intervention up...

Osteoclasts are large, multinucleated, and bone-resorbing cells of the monocyte-macrophage lineage that formed by fusion monocytes or macrophage precursors. Excessive bone resorption is one most significant cellular mechanisms leading to osteolytic diseases, including osteoporosis, periodontitis, periprosthetic osteolysis. The main physiological function osteoclasts absorb both hydroxyapatite mineral component organic matrix bone, generating characteristic appearance on surface bones. There...

Objective: To explore the effect of 3D printing technology in assisting treatment infection after hip arthroplasty by using personalized antibiotic-loaded bone cement spacers.Methods: A retrospective analysis was conducted on 40 patients with postoperative treated our hospital between May 2013 and March 2022. The were divided into two groups based whether they received a spacer made before surgery: group (n=20) conventional (n=20). consisted 13 males aged 47-75 years 7 females 57-78 years. 9...

To explore the effect of 3D-printing technology in assisting treatment periprosthetic infection after total hip arthroplasty (THA) by using personalized antibiotic-loaded bone cement (ALBC) spacers. The data 40 patients with postoperative THA were retrospectively analyzed. divided into 3D printing group (age 47-78 years) and conventional 57-78 years), 20 cases each group. In stage I surgery, used printed silicone molds to create ALBC spacers, while traditional manual methods. After was...

Neurogenic bowel dysfunction (NBD) manifested as constipation and fecal incontinence often occurs after spinal cord injury (SCI). NBD affects patients' quality of life is an urgent clinical problem to be solved. The mechanism related central autonomic nervous system dysfunction, intestinal changes in microorganism composition abnormal content neurotransmitters. evaluation method mainly based on scoring imaging, which lacks unified criteria, the treatment for combination traditional Chinese...