A5046144435- Inflammatory Bowel Disease
- Food Allergy and Anaphylaxis Research
- Eosinophilic Esophagitis
- Allergic Rhinitis and Sensitization
- IL-33, ST2, and ILC Pathways
- Microscopic Colitis
- Asthma and respiratory diseases
- Helicobacter pylori-related gastroenterology studies
- Autoimmune and Inflammatory Disorders Research
- T-cell and B-cell Immunology
- Dermatology and Skin Diseases
- Immune Cell Function and Interaction
- Immunodeficiency and Autoimmune Disorders
- Cell Adhesion Molecules Research
- Gastrointestinal motility and disorders
- Mast cells and histamine
- Immunotherapy and Immune Responses
- Pharmacological Effects of Natural Compounds
- Eosinophilic Disorders and Syndromes
- Contact Dermatitis and Allergies
- Psoriasis: Treatment and Pathogenesis
- Atherosclerosis and Cardiovascular Diseases
- TGF-β signaling in diseases
- Whipple's Disease and Interleukins
- Gastrointestinal disorders and treatments
Icahn School of Medicine at Mount Sinai
2016-2025
Child Health and Development Institute
2015-2025
New York University
2022
The Mount
2020-2022
Mount Sinai Hospital
2014-2015
Sinai Hospital
2011-2014
Sensitization to foods often occurs in infancy, without a known prior oral exposure, suggesting that alternative exposure routes contribute food allergy. Here, we tested the hypothesis peanut proteins activate innate immune pathways skin promote sensitization. We exposed mice protein extract on undamaged areas of and observed repeated topical allergens led sensitization anaphylaxis upon rechallenge. In mice, this epicutaneous induced components Ara h 1 2, which is also human Both crude 2...
ABSTRACT Background: Ustekinumab is an effective therapy for Crohn disease currently approved adults. Off‐label use in the pediatric population increasing, but its effectiveness this age group has not been reported. Aims: The aim of study was to describe real‐world experience with ustekinumab at a tertiary care inflammatory bowel (IBD) center. Methods: As part ongoing observational cohort biologic‐treated IBD patients initiated October 2014, data on demographics, behavior, location and...
Abstract Background Nontraditional combination of existing therapies is often the only option to avoid surgery in refractory inflammatory bowel disease (IBD) patients. We aim assess efficacy and safety concomitant use 2 biologic or tofacitinib a pediatric IBD cohort. Methods As part an ongoing single-center observational cohort study therapeutic outcomes patients (younger than 18 years), data were collected for receiving dual therapy. Primary outcome was 6 months steroid-free remission....
The skin immune system must discriminate between innocuous antigens and pathogens. Antigen applied topically using a Viaskin® patch elicits tolerance that can suppress colitis food allergy. Here we show how topical antigen is acquired presented by dendritic cells in the skin. Topical Langerhans (LC) CD11b+ cDC2s but not cDC1s, both LCs reaching lymph node prime T expand LAP+ Tregs. However, are neither required nor sufficient for cell priming, have no role induction. Conversely,...
Upadacitinib (UPA) is a novel selective JAK inhibitor approved for adults with ulcerative colitis (UC) and positive phase 3 data Crohn's disease (CD). Pediatric off-label use common due to delays in pediatric approvals; real-world on UPA are needed understand the safety effectiveness IBD.
Epstein Barr virus (EBV) is a human herpes that infects 90% of the world's population and has been linked to development lymphoproliferative disorders (LPDs) immunosuppression. Primary EBV infection in patients with IBD on thiopurines risk factor for LPD, including lymphoma. We aimed describe status pediatric an emphasis those initiating thiopurines.Electronic medical records serologies were reviewed categorized into asymptomatic screening versus suspicion acute infection. before therapy was...
Introduction: Cytochrome P450 (CYP) 3A4 is a major drug metabolizing enzyme for corticosteroids (CS). Epimedium has been used asthma and variety of inflammatory conditions with or without CS. It unknown whether epimedium an effect on CYP how it interacts We sought to determine the effects CYP3A4 affects anti-inflammatory function CS identify active compound responsible this effect. Methods: The activity was evaluated using Vivid high-throughput screening kit. mRNA expression determined in...
Abstract Background Anti-integrin αvβ6 autoantibodies (anti-αvβ6) are present in up to 90% of ulcerative colitis (UC) patients and predate disease development, but there is a paucity data regarding anti-αvβ6 Crohn’s (CD). We hypothesized that would be colonic CD given the shared biological characteristics with UC. Methods measured IgG peripheral blood samples from seven distinct cohorts representing diverse ethnic backgrounds, geographical locations stages including preclinical, incident...
Abstract Anti-integrin αvβ6 autoantibodies (anti-αvβ6) are present in up to 90% of patients with ulcerative colitis (UC), but there is a paucity data regarding anti-αvβ6 Crohn’s disease (CD). We hypothesized that would be colonic CD given the shared biological characteristics UC. measured IgG 1,815 peripheral blood samples from six cohorts both USA and Leuven, Belgium. These represent established incident IBD as well non-IBD controls (HC). compared levels by type (UC, CD, HC) location...
Crohn's disease (CD) is a chronic inflammatory of the gastrointestinal tract. Current medications have potentially serious side effects. Hence, there increasing interest in alternative therapies. We previously demonstrated anti-inflammatory effects Food Allergy Herbal Formula-2 vitro on peripheral blood mononuclear cells (PBMCs) and mucosa from CD subjects. Here, we investigated bioactive compound isolated Ganoderma lucidum (G. lucidum), key herbal constituent Formula-2, vitro.Triterpene...
<b><i>Introduction:</i></b> Molecular studies of hen’s egg allergens help define allergic phenotypes, with IgE to sequential (linear) epitopes on the ovomucoid (OVM) protein associated a persistent disease. Epitope profiles other are largely unknown. The objective this study was construct an epitope library spanning across 7 and further evaluate epitope-specific (<i>ses-</i>)IgE <i>ses-</i>IgG<sub>4</sub> among baked-egg reactive or...
Objective: To assess human skin biopsy specimens from erythema migrans lesions for the presence of infection with multiple strains Lyme disease spirochete, Borrelia burgdorferi.Design: Skin were obtained prospectively patients migrans.To determine allelic differences and strain identification B burgdorferi, analyzed by cold singlestrand conformation polymorphism an amplified fragment outer surface protein C (ospC) gene.Further single-strand patterns ospC genes culture isolates compared...
Introduction Food allergy is a significant public health problem with limited treatment options. As Allergy Herbal Formula 2 (FAHF-2) showed potential as food treatment, we further developed purified version named EBF-2 and identified active compounds. We investigated the mechanisms of on IgE-mediated peanut (PN) its compound, berberine, IgE production. Methods plasma cell line U266 cells were cultured FAHF-2, their effects production compared. was evaluated in murine PN model for effect...
Approximately 10% of children with ulcerative colitis (UC) undergo colectomy ileal pouch-anal anastomosis (IPAA). We aimed to describe the postoperative outcomes, an emphasis on chronic pouch inflammation including de novo Crohn disease (CD) at a tertiary care inflammatory bowel center.Electronic medical records all who underwent ≤18 years between 2008 and 2017 were reviewed. Clinical laboratory data recorded. Primary outcome was frequency CD. Secondary outcomes included early (≤30 days from...
Anti-tumour necrosis factor [anti-TNF] induced skin reactions are common adverse events in paediatric inflammatory bowel disease [IBD]. We aimed to report on outcomes of children with anti-TNF who switched ustekinumab [UST] vs. continued therapy.Charts were reviewed for IBD patients reactions. Skin reactions, including psoriasiform dermatitis [PD], classified as mild or severe based a severity score. Primary outcome was frequency resolution at 6 months. Secondary combined clinical remission...
The aim of this study was to determine the use complementary and alternative medicine (CAM) in an inflammatory bowel disease population at a single pediatric center. secondary aims were predictors CAM assess parental attitude use. A survey developed that distributed electronically given out clinic. Two hundred thirty-five surveys analyzed. Thirty-six percent respondents reported their children had used CAM, while 19.6% current users. Sixty-three "extremely" or "very supportive" 57.6% would...
Abstract Background Cytomegalovirus (CMV) can be reactivated in ulcerative colitis (UC), but its role progression of inflammation is unclear. Risk factors include severe and treatment with immunosuppressive medications, particularly corticosteroids immunomodulators. Methods We report a case cytomegalovirus pediatric patient pancolitis who had been refractory to aminosalicylate, infliximab, ustekinumab was clinical remission transmural response on upadacitinib. Results This 13-year-old male...