Journal Article Portfolio Selection with Parameter and Model Uncertainty: A Multi-Prior Approach Get access Lorenzo Garlappi, Garlappi University of Texas at Austin Address correspondence to McCombs School Business, Austin, TX 78712, or e-mail: lorenzo.garlappi@mccombs.utexas.edu. Search for other works by this author on: Oxford Academic Google Scholar Raman Uppal, Uppal London Business CEPR Tan Wang British Columbia CCFR The Review Financial Studies, Volume 20, Issue 1, January 2007, Pages...

Abstract In this paper, we study intertemporal portfolio choice when an investor accounts explicitly for model misspecification. We develop a framework that allows ambiguity about not just the joint distribution of returns all stocks in portfolio, but also different levels marginal any subset these stocks. find overall is high, then small differences return will result significantly underdiversified relative to standard mean‐variance portfolio.

This paper constructs a space of states the world representing exhaustive uncertainty facing each player in strategic situation. The innovation is that preferences are restricted primarily by regularity conditions and need not conform with subjective expected utility theory. construction employs hierarchy preferences, rather than beliefs as standard Bayesian model. framework sufficiently general to accommodate averse such exhibited Ellsberg paradox, allow common knowledge (or Choquet...

Abstract Background The purpose of this study is to analyze the influencing factors associated with Long-COVID in patients infected Omicron variant COVID-19 Changchun City, Jilin Province, China three months after discharge March 2022. Methods In study, we conducted a telephone follow-up based on real-world data collected from Affiliated Hospital University Chinese Medicine, Tongyuan Shelter and Infectious Disease during epidemic We used Global Clinical Platform Case Report Form for Post...

Purpose: Geographic atrophy (GA), an advanced form of dry age-related macular degeneration (AMD), has limited treatment options. This study introduces a novel mouse model featuring expanding GA patch that can be used to test mechanisms and therapeutics. Methods: C57Bl/6J male mice (n = 96) aged 9–10 weeks received intraperitoneal (IP) injection 20 mg/kg sodium iodate (NaIO3). In vivo confocal scanning laser ophthalmoscope (cSLO) optical coherence tomography imaging were done at one, four,...

In this paper we develop a model of intertemporal portfolio choice where an investor accounts explicitly for the possibility misspecification. This work is motivated by difficulty in estimating precisely probability law asset returns. Our contribution to framework that allows ambiguity about joint distribution returns all stocks being considered portfolio, and also different levels marginal any subset these stocks. We then use derive closed-form optimal weights who illustrate calibrating it...

Abstract Background Alterations in epigenetic factors are recognized as key contributors to the emergence of human cancer. The active and reversible alteration N6‐methyladenosine (m6A) RNA is crucial for controlling gene activity determining cellular destiny. Even with these insights, triggering KIAA1429 (also called VIRMA) its role lung adenocarcinoma (LUAD) mostly unclear. As a result, objective this study was elucidate how contributes cancer development LUAD. Methods This utilized...

In this paper, we study the asset pricing implication of imprecise knowledge about rare events. Modeling events as jumps in aggregate endowment, explicitly solve equilibrium prices a pure-exchange economy with representative agent who is averse not only to risk but also model uncertainty respect Our results show that there are three components equity premium: diffusive-risk premium, jump-risk and "rare event premium." While first two premia generated by aversion, last one driven exclusively...

Sinonasal mucosal melanoma (SNMM) is a rare tumor with poor prognosis. This study aimed to assess the clinical and imaging features, progression, treatment, possible prognostic factors of SNMM.Thirty-six patients SNMM were retrospectively reviewed in Department Otolaryngology & Head Neck Surgery Xinhua Hospital from January 2008 December 2017.The age first diagnosis was 67.4±10.8 years; most common symptoms included epistaxis, nasal obstruction, headache, facial pain. Most tumors originated...

Abstract Background To comprehend the complexities of pathophysiological mechanisms and molecular events that contribute to proliferative diabetic retinopathy (PDR) evaluate diagnostic value aqueous humor (AH) in monitoring onset PDR. Methods A cohort containing 16 PDR 10 cataract patients another validation 8 4 were studied. AH was collected subjected proteomics analyses. Bioinformatics analysis a machine learning-based pipeline called inference biomolecular combinations with minimal bias...

To report a novel surgical approach for the scleral fixation of Rayner 620 H intraocular lens (IOL) with Gore-Tex suture and its outcomes at 6 months postoperatively.19 consecutive patients who underwent IOL Peking Union Medical College Hospital between June 2020 2021 were included. Data on best-corrected visual acuity (BCVA), spherical equivalent, total astigmatism/axis, short-term long-term complications, corresponding management follow-up collected.Nineteen (11 men 8 women) mean age 62.7...

The aim of this study was to observe the treatment characteristics verbenalin on a prostatitis mouse model. Give Xiaozhiling injection in prostate locally make High, medium and low doses were each given different groups. amount water determined 14th, 28th. number white cells lecithin corpuscle density prostatic fluid determined. Morphological changes prostate, testis, epididymis kidney detected. Compared with model control group, mice treated high, had significantly increased amounts water,...

In this report, the effects of cynomorium flavonoids on mouse model perimenopausal depression were investigated.60 ovariectomized female mice randomly divided into 6 groups evenly: high, medium and low doses (400 mg kg(-1), 200 100 kg(-1)), Gengnian'an capsule group (675 soy isoflavones soft (250 group. Give corresponding drug five days after surgery once a day, consecutive thirty days. The control given water same volume. related applied with different stress for eighteen Kill remove...

To investigate the changes in aqueous humor (AH) protein profiles before and after intravitreal conbercept (IVC) treatment proliferative diabetic retinopathy (PDR) patients. Ten PDR patients provided 20 samples of AH (pre group) (post IVC treatment. Liquid chromatography-tandem mass spectrometry was performed to identify proteins. Bioinformatics analysis used explore functional relevance differentially expressed proteins (DEPs) hub Parallel reaction monitoring (PRM) method verify another 8 4...

Microbialites, often considered as a signal of extreme marine environment, are common in the Lower Triassic strata South China where they flourished aftermath end-Permian mass extinction. Early microbialite facies known to vary palaeogeographically, perhaps due differing climates, ocean chemistry, and water depths. This paper provides first record brief, but spectacular development microbialites extinction at Panjiazhuang section, Changxing Region Zhejiang Province (eastern China). Here,...