A5101979445- Bladder and Urothelial Cancer Treatments
- Air Quality and Health Impacts
- Cancer Immunotherapy and Biomarkers
- Climate Change and Health Impacts
- Epigenetics and DNA Methylation
- Atmospheric chemistry and aerosols
- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Intergenerational Family Dynamics and Caregiving
- Tissue Engineering and Regenerative Medicine
- Radiation Dose and Imaging
- Immune cells in cancer
- Immune Response and Inflammation
- Spinal Dysraphism and Malformations
- Immune Cell Function and Interaction
- Noise Effects and Management
- Histone Deacetylase Inhibitors Research
- Bone health and osteoporosis research
- GDF15 and Related Biomarkers
- Peptidase Inhibition and Analysis
- Developmental Biology and Gene Regulation
- S100 Proteins and Annexins
- Meningioma and schwannoma management
- Technology Use by Older Adults
- Orthopedic Surgery and Rehabilitation
China Medical University
2018-2024
Institute of Biomedical Sciences, Academia Sinica
2024
National Health Research Institutes
2018-2024
University of California, Los Angeles
2004-2024
National Yang Ming Chiao Tung University
2018-2024
Zhongnan Hospital of Wuhan University
2024
Wuhan University
2024
Shanxi Medical University
2009-2021
Tongji University
2020
Shanghai Academy of Environmental Sciences
2020
Abstract γ-Aminobutyric acid (GABA) is both a major inhibitory neurotransmitter in the CNS and product of β cells peripheral islets. Our previous studies, those others, have shown that T express functional GABAA receptors. However, their subunit composition physiological relevance are unknown. In this study, we show subset receptor subunits expressed by CD4+ cells, including δ confers high affinity for GABA sensitivity to alcohol. at relatively low concentrations down-regulated effector cell...
Abstract Objective To assess the usefulness of measuring serum matrix metalloproteinase 3 (MMP‐3) and macrophage colony‐stimulating factor (M‐CSF) in patients with ankylosing spondylitis (AS). Methods Serum levels MMP‐3 M‐CSF were measured AS who did not receive infliximab treatment. These compared those 28 healthy subjects. Results In group treated biologics, both correlated Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) values, but each other. Logistic regression analysis...
Inflammation is considered as a key pathogenesis factor of dementia and epilepsy. However, epilepsy's association with dementia, particularly its role in the development remains unclear. To evaluate between epilepsy risk Taiwan, we have now conducted retrospective cohort study comprising 675 individuals (age, ≥50 years) 2,025 matched control subjects without In order to match diagnosed those no diagnosis (comparison cohort), utilized exact matching at ratio 1:3. Compared comparison cohort,...
Introduction: We hypothesized that hypertensive patients harbor a higher risk of urinary bladder (UB) cancer. Material and methods: performed population-based cohort study on adults using National Health Insurance Research Database (NHIRD) dataset. Hypertension comparison non-hypertensive (COMP) groups comprising 39,618 each were propensity score-matched by age, sex, index date, medical comorbidities. The outcome was incident UB cancer validated procedure codes. constructed multivariable Cox...
Small cell carcinoma of the bladder (SCCB) is a rare and lethal phenotype cancer. The pathogenesis molecular features are unknown. Here, we established genetically engineered SCCB model cohort patient urothelial samples to characterize similarities differences between cancer phenotypes. We demonstrate that shares origin with other phenotypes by showing cells driven set defined oncogenic factors give rise mixture tumor phenotypes, including small carcinoma, squamous carcinoma. Tumor-derived...
Cisplatin based chemotherapy regimens form the basis of systemic bladder cancer treatment, although they show limited response rates and efficacy. Recent molecular analysis revealed a high incidence mutations in chromatin regulatory genes, suggesting therapeutic avenue for histone deacetylase inhibitors. We investigated ability novel inhibitor AR-42 to synergize with cisplatin preclinical models cancer.We assessed pan-histone without destroy cells by survival apoptosis assays vitro, growth...
In satellite laser altimetry, it is a challenging task to accurately extract peak positions from full waveforms due the overlapped or weak peaks within large footprints, which substantially affects subsequent applications. this article, improve ranging resolution and accuracy, we propose novel approach by combining deconvolution with Gaussian decomposition. The applied in two main phases: 1) first used remove system contribution (the transmit pulse spreading over several nanoseconds, noise);...
165 Background: Small cell/neuroendocrine cancers irrespective of origin share aggressive phenotypes. Pembrolizumab (MK-3475) is a humanized antibody targeting programmed cell death protein 1 (PD-1) that has shown activity against small lung cancers. Preclinical studies showed molecular commonality amongst across multiple tissue types. This study evaluated the safety and efficacy signals pembrolizumab chemotherapy in patients with cancer prostate urothelium. Methods: Patients locally...
Tumor invasion and metastases represent a complex series of molecular events that portends poor prognosis. The contribution inflammatory pathways mediating this process is not well understood. Nod-like receptors (NLRs) innate immunity function as intracellular sensors pathogen motifs danger molecules. We propose role NLRs in tumor surveillance programming tumor-infiltrating lymphocytes (TILs). In study, we examined the downstream serine/threonine tyrosine kinase Rip2 murine model bladder...
This study aimed to investigate whether long-term exposure airborne hydrocarbons, including volatile organic compounds, increases the risk of developing retinal vein occlusion (RVO) among population Taiwan. A retrospective cohort involving 855,297 people was conducted. Cox proportional hazards regression analysis fitted multiple pollutant models for two targeted pollutants, total hydrocarbons (THC), nonmethane (NMHC) were used, and RVO estimated. The chi-squared test one-way variance used...
Abstract Inhibition of tumor neovascularization has profound effects on the growth solid tumors. Our previous studies have shown effect VEGF165‐PE38 recombinant immunotoxin proliferation and apoptosis in human umbilical vein endothelial cells vitro . In this study, we explored direct inhibition angiogenesis chick chorioallantoic membrane antiangiogenic therapy a malignant glioma model. HEK293 were transfected with pVEGF165PE38‐IRES2‐EGFP plasmid. ELISA was used to confirm expression cells....
Exposure to air pollutants is known have adverse effects on human health; however, little about the association between hydrocarbons in and an ischemic stroke (IS) event. We investigated whether long-term exposure airborne hydrocarbons, including volatile organic compounds, increased IS risk. This retrospective cohort study included 283,666 people aged 40 years or older Taiwan. Cox proportional hazards regression analysis was used fit single- multiple-pollutant models for two targeted...
Background: Despite being the gold standard for diagnosing osteoporosis, dual-energy X-ray absorptiometry (DXA) is an underutilized screening tool osteoporosis. Objectives: This study proposed and validated a controllable feature layer of convolutional neural network (CNN) model with preprocessing image algorithm to classify osteoporosis predict T-score on proximal hip region via simple radiographs. Design: was single-center, retrospective study. Methods: An dataset 3460 unilateral images...
Small cell neuroendocrine cancers share biologic similarities across tissue types, including transient response to platinum-based chemotherapy with rapid progression of disease. We report a phase 1b study pembrolizumab in combination 15 patients stage III-IV small bladder (cohort 1) or cell/neuroendocrine prostate 2). Overall rate (ORR) is 43% two-year overall survival (OS) 86% (95% confidence interval [CI]: 0.63, 1.00) for cohort 1 and 57% CI: 0.30, 2. Treatment tolerated well grade 3...
The influence of pattern recognition receptor (PRR) signaling in the prostate tumor microenvironment remains unclear. Although there may be a role for PRR agonists as adjuvants to therapy, prior evidence suggests promoting well inhibiting mechanisms. purpose this study is examine key Toll-like (TLR) adaptor protein myeloid differentiation primary response gene 88 (MyD88) cancer development.MyD88(-/-) mice C57Bl6 background were crossed with transgenic adenocarcinomas mouse (TRAMP) create...
Sarcopenia is a progressive and generalized skeletal muscle disorder associated with poor health outcomes in older adults. However, its association the risk of fracture yet to be clarified. Therefore, this study aimed assess incidence consequence osteoporosis-related fractures among patients sarcopenia Taiwan. A retrospective, population-based on 616 sarcopenia, aged >40 years, 1232 individuals without was conducted evaluate claims data from Taiwan’s National Health Insurance Research...
Particulate matter and volatile organic compounds, including total hydrocarbons (THCs), are major ambient air pollutants. Primary nonmethane (NMHCs) originate from vehicle emissions. The association between pollution urinary bladder cancer (UBC) is debatable. We investigated whether long-term exposure to increases UBC risk among people aged ≥ 20 years in Taiwan. Linkage dataset research with longitudinal design was conducted 589,135 initially cancer-free individuals during 2000-2013; 12...
Abstract Background We investigated the health status of some workers exposed to occupational noise in Xinjiang, and explored influencing factors their level. aimed determine key protection groups hazards, which might provide basis for development targeted prevention measures. Methods used descriptive analysis investigate a total 11,800 participants who underwent examination Xinjiang Occupational Disease Prevention Hospital. Results The hearing abnormality rate exposure was 8.03%, higher...
Abstract Classic dye injection methods yielded amazingly detailed images of normal and pathological development the cardiovascular system. However, because these rely on beating heart diffuse dyes, vessels visualized have been limited to arterial tree, our knowledge vein is lagging. In order solve this problem, we injected pigmented methylsalicylate resins in mouse embryos after they were fixed made transparent. This new technique allowed us image venous system prompted discovery multiple...
The cause of trigger fingers remains uncertain. High lipid levels in the blood may reduce supply to distal and promote inflammation. We aimed explore association between hyperlipidemia finger. A nationwide population-based cohort study using longitudinal data from 2000 2013, 41,421 patients were included 82,842 age- sex-matched control cohort. mean age was 49.90 ± 14.73 years 49.79 14.71 After adjusting for possible comorbidities, hazard ratio finger 4.03 (95% confidence interval [CI],...
Taiwan started to be an 'aging society' from 1993, and the aging process will progress more rapidly due markedly decreased child birth in recent year. Facing very high old age dependency ratio as 1 2 year 2030 which means every two working persons (age 15 - 64 years) have support one elderly people. That would enormous burden for family society. In this study a U-Care system was developed implemented satellite city region of Taipei metropolitan area Taiwan, provide comprehensive living...
Alzheimer's disease, the most common cause of dementia among elderly, is a progressive and irreversible neurodegenerative disease. Exposure to air pollutants known have adverse effects on human health, however, little about hydrocarbons in that can trigger event.We aimed investigate whether long-term exposure airborne increases risk developing dementia.The present cohort study included 178,085 people aged 50 years older Taiwan. Cox proportional hazards regression analysis was used fit...