A5055877565- Cancer-related gene regulation
- RNA modifications and cancer
- Mesenchymal stem cell research
- Virus-based gene therapy research
- Cancer-related molecular mechanisms research
- Telomeres, Telomerase, and Senescence
National Clinical Research
2024
Air Force Medical University
2024
Zhejiang University
2008
Periodontitis is a chronic inflammatory disease that causes loss of periodontal support tissue. Our objective was to investigate the mechanism by which METTL3-mediated N6-methyladenosine modification regulates osteogenic differentiation through lncRNA in mesenchymal stem cells patients with periodontitis (pPDLSCs).
Previous studies have reported immortalization and tumorigenicity of human mesenchymal stem cells (hMSCs) transduced with exogenous telomerase reverse transcriptase (hTERT). We also established a line hMSCs hTERT (hTERT-hMSCs) we cultured these for 290 population doublings (PDs) during which they demonstrated large proliferation potential but no tumorigenicity. The aim this study was to investigate the protein expression profile hTERT-hMSCs two-dimensional gel electrophoresis peptide mass...