A5077039051- Ion channel regulation and function
- Neurobiology and Insect Physiology Research
- Neuroscience and Neuropharmacology Research
- Erythrocyte Function and Pathophysiology
- Ion Channels and Receptors
- Parkinson's Disease Mechanisms and Treatments
- Hearing, Cochlea, Tinnitus, Genetics
- Neuroinflammation and Neurodegeneration Mechanisms
- Sirtuins and Resveratrol in Medicine
- Cardiac electrophysiology and arrhythmias
- Neurological disorders and treatments
- Plant and Biological Electrophysiology Studies
- Nerve injury and regeneration
- Cellular Mechanics and Interactions
- Tryptophan and brain disorders
- Insect and Arachnid Ecology and Behavior
- Genetic Neurodegenerative Diseases
- Hereditary Neurological Disorders
- Stress Responses and Cortisol
- Physiological and biochemical adaptations
- Alzheimer's disease research and treatments
- RNA regulation and disease
- Neurological Disease Mechanisms and Treatments
- Ion Transport and Channel Regulation
- Neurogenesis and neuroplasticity mechanisms
Shenzhen Bay Laboratory
2021-2025
Capital Medical University
2024-2025
Union Hospital
2024-2025
Huazhong University of Science and Technology
2024-2025
Union Hospital
2024-2025
Affiliated Hospital of Southwest Medical University
2025
Hunan Normal University
2025
Ministry of Agriculture and Rural Affairs
2024
Northwest A&F University
2024
Chongqing Academy of Animal Science
2024
Mechanical stimuli, including tactile and sound signals, convey a variety of information important for animals to navigate the environment avoid predators. Recent studies have revealed that Drosophila larvae can sense harsh or gentle touch with dendritic arborization (da) neurons in body wall detect vibration chordotonal organs (Cho). Whether they also respond from their predators remains an open question. Here we report wasps yellow jackets, as well pure tones frequencies are represented...
Transmembrane channel-like (TMC) 1 and 2 are required for the mechanotransduction of mouse inner ear hair cells localize to site in cell stereocilia. However, it remains unclear whether TMC1 TMC2 indeed ion channels they can sense mechanical force directly. Here we express from green sea turtle (CmTMC1) budgerigar (MuTMC2) insect cells, purify reconstitute proteins, show that liposome-reconstituted CmTMC1 MuTMC2 proteins possess channel activity. Furthermore, by applying pressure...
How to build and maintain a reliable yet flexible circuit is fundamental question in neurobiology. The nervous system has the capacity for undergoing modifications adapt changing environment while maintaining its stability through compensatory mechanisms, such as synaptic homeostasis. Here, we describe our findings Drosophila larval visual system, where variation of sensory inputs induced substantial structural plasticity dendritic arbors postsynaptic neuron concomitant changes physiological...
Magnesium is an essential ion for numerous physiological processes. MgtE a Mg2+ selective channel involved in the maintenance of intracellular homeostasis, whose gating regulated by levels. Here, we report that ATP binds to MgtE, regulating its Mg2+-dependent gating. Crystal structures MgtE-ATP complex show CBS domain MgtE. Functional studies support binding enhances affinity within concentrations this divalent cation, enabling function as vivo sensor. dissociation from upregulates influx at...
Abstract Birds, reptiles and insects have the ability to discriminate humidity levels that influence their survival geographic distribution. Insects are particularly susceptible changes due high surface area volume ratios, but it remains unclear how sensors transduce signals. Here we identified Or42b-expressing olfactory sensory neurons, which required for moisture attraction in Drosophila . The sensilla housing Or42b neurons show cuticular deformations upon moist air stimuli, indicating a...
NompC is a mechanosensitive ion channel responsible for the sensation of touch and balance in Drosophila melanogaster. Based on resolved cryo-EM structure, we performed all-atom molecular dynamics simulations electrophysiological experiments to study atomistic details gating. Our results showed that could be opened by compression intracellular ankyrin repeat domain but not stretch, number hydrogen bonds along force convey pathway are important mechanosensitivity. Under compression, bundled...
Increasing evidences show that the etiology of Parkinson's disease (PD) is multifactorial. Studying combined effect several factors becoming a hot topic in PD research. On one hand, iron essential trace metals for human body; on other may be involved etiopathogenesis PD. In our present study, rats with increased neonatal (120 μg/g bodyweight) supplementation were treated rotenone (0.5 mg/kg) when they aged to 14 weeks. We observed and co-treatment induced significant behavior deficits...
Sepsis-induced myocardial dysfunction (SIMD) is a serious sepsis complication with high mortality, yet current diagnostic and therapeutic approaches remain limited. The lack of early, specific biomarkers effective treatments necessitates exploration novel mechanisms. Recently, cuproptosis has been implicated in various diseases, but its role SIMD unclear. This study aimed to identify cuproptosis-related potential agents, supported by animal model validation. Four GEO datasets (GSE79962,...
Sepsis induces multi-organ damage, including myocardial dysfunction, which is often reversible. However, the role of cell senescence in sepsis-induced dysfunction (SIMD) remains understudied. This study aimed to investigate gene expression changes related aging sepsis. Transcriptomic datasets (GSE79962 and GSE141864) were analyzed identify senescence-related genes (SRGs) by intersecting differentially expressed (DEGs) with CellAge database. Functional enrichment protein-protein interaction...
Defecation allows the body to eliminate waste, an essential step in food processing for animal survival. In contrast extensive studies of feeding, its obligate counterpart, defecation, has received much less attention until recently. this study, we report our characterizations defecation behavior Drosophila larvae and neural basis. display cycles stereotypic frequency, involving sequential contraction hindgut anal sphincter. The requires two groups motor neurons that innervate sphincter,...
Abstract: Aging is one of the strongest risk factors for Parkinson’s disease (PD). SIRT2 has been implicated in aging process. It pertinent to investigate role aging-related dopaminergic neurotoxicity and develop effective therapeutic strategies PD through use animals. In this study, we observed that rotenone induced significant behavior abnormality striatal dopamine depletion rats, while it did not do so young rats. No change serotonin level was rats after administration. There also...
Biochar application to soil has proven be an excellent approach for decreasing the concentration of auto-toxic compounds and promoting plant growth in continuous-cropping fields. However, mechanisms underlying action pathway among biochars, tobacco remain unknown. In this study, we conducted experiment tracking incidence rate black rot a 3-year pot trial response biochar treatment intensity compared with that non-biochar treatment. inhibited rot. Using ultra-high-performance liquid...