A5012888044- Neurobiology and Insect Physiology Research
- Photoreceptor and optogenetics research
- Receptor Mechanisms and Signaling
- Lipid metabolism and biosynthesis
- Blood Coagulation and Thrombosis Mechanisms
- Protein Kinase Regulation and GTPase Signaling
- Retinal Development and Disorders
- Endoplasmic Reticulum Stress and Disease
- Neuroscience and Neuropharmacology Research
- Acute Myocardial Infarction Research
- Cellular transport and secretion
- Cardiac electrophysiology and arrhythmias
- Protease and Inhibitor Mechanisms
- Erythrocyte Function and Pathophysiology
- Nicotinic Acetylcholine Receptors Study
- Plant Molecular Biology Research
- Ion channel regulation and function
National Institute of Neurological Disorders and Stroke
2019-2024
National Institutes of Health
2019-2021
Columbia University
2002-2003
University of Texas Health Science Center at Dallas
1987
Recent studies identify conventional protein kinase C (PKC) isoform phosphorylations at conserved residues in the activation loop and terminus as maturational events that influence enzyme activity targeting but are not dynamically regulated by second messengers. In contrast, this study identifies phorbol 12-myristoyl 13-acetate (PMA)- norepinephrine-induced of PKCε (at C-terminal hydrophobic motif) PKCδ loop) accompany endogenous novel PKC (nPKC) neonatal rat cardiomyocytes. Agonist-induced...
Proteases elaborated by inflammatory cells in the heart would be expected to drive cardiac fibroblasts proliferate, but protease-activated receptor (PAR) function has never been considered. This study demonstrates that PAR-1 is only known PAR family member functionally expressed and activation thrombin leads increased DNA synthesis fibroblasts. The increase induced substantially exceeds effects of other G protein-coupled agonists this cell type. stimulates phosphoinositide hydrolysis...
Abstract Lipid shuttling between neurons and glia contributes to the development, function, stress responses of nervous system. To understand how a neuron acquires its lipid supply from specific lipoproteins their receptors, we perform combined genetic, transcriptome, biochemical analyses in developing Drosophila larval brain. Here report, astrocyte-derived secreted lipocalin Glial Lazarillo (GLaz), homolog human Apolipoprotein D (APOD), neuronal receptor, brain-specific short isoforms...
Abstract Glia derived secretory factors play diverse roles in supporting the development, physiology, and stress responses of central nervous system (CNS). Through transcriptomics imaging analyses, we have identified Obp44a as one most abundantly produced proteins from Drosophila CNS glia. Protein structure homology modeling Nuclear Magnetic Resonance (NMR) experiments reveal a fatty acid binding protein (FABP) with high affinity towards long-chain acids both native oxidized forms. Further...
Abstract ON and OFF selectivity in visual processing is encoded by parallel pathways that respond to either light increments or decrements. Despite lacking the anatomical features support split channels, Drosophila larvae effectively perform visually-guided behaviors. To understand principles guiding computation this simple circuit, we focus on investigating physiological properties behavioral relevance of larval interneurons. We find vs. discrimination circuit emerges through light-elicited...
Significance Cholinergic neurotransmission in the central nervous system contributes immensely to animal behavior and is linked a multitude of neuropsychiatric disorders humans. However, contrast well-established role glutamate receptor signaling developing brain, it remains unclear whether mediated by acetylcholine receptors also major effector neural development plasticity. Here, we address this question Drosophila system, where most excitatory synapses use as main neurotransmitter. Our...
ABSTRACT ON and OFF selectivity in visual processing is encoded by parallel pathways that respond to either increments or decrements of light. Despite lacking anatomical features support split channels, Drosophila larvae effectively perform visually-guided behaviors. To understand principles guiding computation this simple circuit, we focus on the physiological properties behavioral relevance larval interneurons elucidate their functions processing. We find vs. discrimination circuit emerges...