Purpose This study aimed to report the projected cancer incidence and mortality for year 2024 estimate Korea’s current burden.Materials Methods Cancer data from 1999 2021 were obtained Korea National Incidence Database, 1993 2022 acquired Statistics Korea. by fitting a linear regression model observed age-specific rates against their respective years multiplying anticipated population 2024. A joinpoint was used determine in which trend changed significantly; we only of latest...

Impaired blood-brain barrier function represents an important component of hypoxic-ischemic brain injury in the perinatal period. Proinflammatory cytokines could contribute to ischemia-related dysfunction. IL-6 increases vascular endothelial cell monolayer permeability vitro. However, contributions abnormalities have not been examined immature vivo. We generated pharmacologic quantities ovine-specific neutralizing anti-IL-6 mAbs and systemically infused into fetal sheep at 126 days gestation...

Purpose This study aimed to project cancer incidence and mortality for 2025 estimate Korea's current burden. Materials Methods Cancer data from 1999 2022 were obtained the Korea National Incidence Database, while 1993 2023 acquired Statistics Korea. projected by fitting a linear regression model observed age-specific rates against their respective years then multiplying anticipated population 2025. A joinpoint was applied identify significant changes in trends, using only most recent trend...

Lymphocyte recovery after autologous stem cell transplantation (ASCT) has been shown to be associated with positive clinical outcome in non-Hodgkin's lymphoma (NHL). This study sought identify variables that affect lymphocyte and survival ASCT.A retrospective analysis of outcomes 97 consecutive patients NHL who underwent ASCT a single center from August 1999 January 2008 was conducted.A significant relationship not observed between infused count days absolute 500 x 10(6)/L or greater...

<i>Background:</i> Wheat is an important food allergen associated with severe allergic reactions, including wheat-dependent exercise-induced anaphylaxis (WDEIA) and wheat-induced (WIA). To diagnose WDEIA, exercise challenge test following wheat ingestion performed, which time-consuming unsafe. The compound ω-5 gliadin has been identified as a major for WDEIA WIA. We evaluated the diagnostic value of serum immunoglobulin E (IgE) ratios to in adult patients or...

drome associated with beta-lactam antibiotics was 8.9%. 12In hospital nurses without a history of penicillin allergy, the sensitization rate by SPT to penicillins 12%. 13In recent years, cephalosporins have been more commonly prescribed than in major hospitals this country.Therefore, we investigated rates used HCW single university hospital.We two methods: and measurement specific IgE antibodies conjugated human serum albumin (HSA).

vasculitis, anaphylaxis, 4 ototoxicity, neutropenia, fixed drug eruptions, fever, phlebitis, nephrotoxicity, 5 thrombocytopenia, 6 and, more rarely, Stevens-Johnson or rash with eosinophilia and systemic symptoms (DRESS) syndrome have been reported. 7A recent study conducted at six Korean pharmacovigilance centers (PVCs) reported that antibiotics including vancomycin were the most prevalent causes of ADRs, skin manifestations common in spontaneously ADRs. 8Of 1,418 cases study, 3.1%...

Although the mutation status of KRAS is highly concordant in primary and metastatic lesions, it has not been generalized to other major pathway genes.In this study, 41 genes were evaluated mutational profiles compared 46 colorectal cancer patients with paired surgical specimens lesions: synchronous (n=27) metachronous (n=19) lesions. A high-throughput mass spectrometry-based genotyping platform validated by orthogonal chemistry, OncoMap v.4.4, was used evaluate formalin-fixed,...

Primary immunodeficiency disease (PID) is a rare disorder in adults.Most often, serious forms are detected during infancy or childhood.However, mild of PID may not be diagnosed until later life, and some types humoral occur adulthood.The purpose this study was to identify clinical features Korean adults.A retrospective performed on 55 adult patients who were as between January 1998 2009 at single tertiary medical center Korea.IgG subclass deficiency the most common phenotype (67%, 37/55),...

Precalcaneal congenital fibrolipomatous hamartomas (PCFHs) are characterized clinically by the presence of unilateral or bilateral, asymptomatic nodules in medial precalcaneal plantar region heel.They skin colored and usually painless nodules.In most patients, lesions appear within first few months life, but they may also be present at birth.Generally PCFHs benign, can grow proportion to growth infants.Here, we report case a 4-month-old boy with solitary, localized skin-colored nodule on his...

<b><i>Objectives:</i></b> This study investigates the clinical significance of gene encoding AP-2ε (TFAP2E) in colorectal cancer (CRC) patients undergoing curative resection. <b><i>Methods:</i></b> A single-institution cohort 248 who underwent resection stage I/II/III CRCs between March and December 2004 was enrolled, 193 whose tumors were available for determination TFAP2E methylation status included analysis....

Abstract Background Extramammary Paget's disease (EMPD) is rare. There are no standard treatments due to its rarity and few clinical trials. Methods The objective of this multicenter study was investigate treatment outcomes Korean patients with advanced/metastatic EMPD. Data were collected retrospectively from 14 institutions participating in Cancer Study Group (KCSG) Rare Committee. Results A total 37 identified. Of these patients, 6 received locoregional therapy as a first‐line treatment....

A 52 year-old woman presented with an incidentally detected retroperitoneal angiosarcoma and multiple hepatic metastases. After chemotherapy weekly paclitaxel doxorubicin, had progressed rapidly. Because few chemotherapeutic options were available for her, sunitinib (37.5 mg/day, daily) as a salvage regimen was administered. Although interrupted after two weeks due to hematologic abnormalities, some metastatic nodules regressed. Therefore, recommenced at reduced dose (25 daily). Serial...

The aim of this study was to evaluate and compare the Child-Turcotte-Pugh (CTP) classification system model for end-stage liver disease (MELD) score in predicting severity systemic inflammatory response living-donor transplantation patients.Recipients graft were allocated a recipient group (n = 39) healthy donors donor 42).The association between CTP classification, MELD scores perioperative cytokine concentrations evaluated.The pro-inflammatory cytokines measured included interleukin...

Purpose:The sensitization rate to Japanese Hop (Hop J) in respiratory allergy patients has increased recent years Korea.We evaluated changes the allergenic potency of J pollen collected 1998 and 2009.Methods: Thirty-five with allergic rhinitis and/or asthma were enrolled.Group I included 21 subjects sensitized at an initial visit group II 14 who developed a new sensitization.Hop pollens 2009 (98 09 extracts) both urban suburban environments (urban extracts).Serum specific IgE levels extracts...

We report a case of 59-year-old man with testicular germ cell tumor who showed new hypermetabolic lesions at the left axillary lymph nodes on post-treatment positron emission tomography-computed tomography (PET-CT) scan. The were found to be caused by an influenza vaccination 10 days prior PET-CT scan and disappeared without additional treatment. To date, he is alive complete remission.

Revascularization of coronary artery stenosis should be based on the objective evidence ischemia.It is common practice for physicians to make decisions revascularization in cardiac catheterization laboratory results angiography, despite fact that angiographic information does not correlate well with functional significance a lesion.Fractional flow reserve (FFR) physiologic parameter which can measured easily during invasive procedure and assess stenosis.FFR-guided strategy reported more...

A CD-ROM and printed material on San-Yin-Jiao pressure to lessen labor pain for women were developed as formal didactic instruction using the same content. prospective, randomized, double-blind study was conducted compare self-learning outcomes software materials. Eighty third-year student nurses randomly allocated either group or group. test administered after 1 week of time. p value < .05 considered statistically significant. Results showed no significant differences between two groups in...

Several studies have validated the clinical efficacy of computerized cognitive training applications. However, few investigated neural substrates these applications using simultaneous multimodal neuroimaging modalities. We aimed to determine effectiveness and corresponding through a approach. Ten patients with mild impairment (MCI), six subjective memory (SMI), 10 normal controls received custom-developed in clinic university hospital. All participants completed 24 sessions training, each...

Recently, interferon gamma releasing assay has been recommended to compensate the tuberculin skin test (TST) for screening latent tuberculosis infection (LTBI). Although it improved detection of LTBI before treatment with tumor necrosis factor blocker, its application immune suppressed patients is limited. We report a case peritoneal (TB) developed in patient who tested positive TST and QuantiFERON-TB Gold (QFT-G) infliximab therapy, emphasize importance monitoring during treatment. A...

Among gastrointestinal emergencies, acute upper bleeding remains a challenging clinical problem owing to significant patient morbidity and costs involved in management. Endoscopic hemostatic therapy is the mainstay of treatment decreases incidence re-bleeding, need for surgery, morbidity, mortality. However, 8%-15% patients with bleeding, endoscopic does not successfully control bleeding. Trans-arterial coil embolization an effective alternative failure; however, this procedure can induce...