A5031166545- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Brain Metastases and Treatment
- Radiomics and Machine Learning in Medical Imaging
- AI in cancer detection
- Head and Neck Surgical Oncology
- Pituitary Gland Disorders and Treatments
- Cell Image Analysis Techniques
- Vascular Malformations Diagnosis and Treatment
- Spectroscopy Techniques in Biomedical and Chemical Research
- Nanoplatforms for cancer theranostics
- Neurofibromatosis and Schwannoma Cases
- Medical Imaging and Analysis
- Intracranial Aneurysms: Treatment and Complications
- Bioinformatics and Genomic Networks
- Brain Tumor Detection and Classification
- Advanced MRI Techniques and Applications
- Bone Tumor Diagnosis and Treatments
- Neurosurgical Procedures and Complications
- Topic Modeling
- Epilepsy research and treatment
- Cerebrospinal fluid and hydrocephalus
- History of Medical Practice
- Digital Imaging for Blood Diseases
- Single-cell and spatial transcriptomics
New York University
2023-2025
NYU Langone Health
2021-2025
Hinge Health
2025
Columbia University Irving Medical Center
2019-2024
Neurological Surgery
2019-2024
Columbia University
2018-2023
Royal College of Physicians
2020
Duke University
2017
Trinity College
2017
Duke Medical Center
2017
The adoption of large language models (LLMs) in healthcare demands a careful analysis their potential to spread false medical knowledge. Because LLMs ingest massive volumes data from the open Internet during training, they are potentially exposed unverified knowledge that may include deliberately planted misinformation. Here, we perform threat assessment simulates data-poisoning attack against Pile, popular dataset used for LLM development. We find replacement just 0.001% training tokens...
Glioblastoma (GBM) diffusely infiltrates the brain and intermingles with non-neoplastic cells, including astrocytes, neurons microglia/myeloid cells. This complex mixture of cell types forms biological context for therapeutic response tumor recurrence. We used single-nucleus RNA sequencing spatial transcriptomics to determine cellular composition transcriptional states in primary recurrent glioma identified three compositional 'tissue-states' defined by cohabitation patterns between specific...
Emerging evidence from epidemiological studies suggests a link between environmental chemical exposure and progression of aggressive breast cancer subtypes. Of all clinically distinct types cancers, the most lethal phenotypic variant is inflammatory (IBC). Overexpression epidermal growth factor receptors (EGFR/HER2) along with estrogen receptor (ER) negativity common in IBC tumor cells, which instead solid mass present as rapidly proliferating diffuse cell clusters. Our previous have...
Detection of glioma recurrence remains a challenge in modern neuro-oncology. Noninvasive radiographic imaging is unable to definitively differentiate true versus pseudoprogression. Even biopsied tissue, it can be challenging recurrent tumor and treatment effect. We hypothesized that intraoperative stimulated Raman histology (SRH) deep neural networks used improve the detection recurrence.We fiber laser-based SRH, label-free, nonconsumptive, high-resolution microscopy method (<60 sec per 1 ×...
The Gamma Knife (GK) Icon (Elekta AB) uses a cone-beam computed tomography (CBCT) scanner and an infrared camera system to support the delivery of frameless stereotactic radiosurgery (SRS). There are limited data on patients treated with GK (GKRS).To describe early experience, process, technical details, short-term outcomes GKRS at our institution.We reviewed patient selection described workflow in detail, including image acquisition, treatment planning, mask-based immobilization, CBCT...
Aneurysmal bone cysts (ABCs) are slow-growing, expansile tumors most often observed in the long bones and lumbar thoracic spine. Anterior column ABCs of spine rare, few cases have described their surgical management, particularly for lesions with extension into odontoid process bilateral C2 pedicles. In present case, authors describe a two-stage strategy resection symptomatic 2.3 × 3.3 2.7-cm ABC cord compression 13-year-old patient. Initial tumor debulking was completed via transoral...
Skull base surgery is a highly innovative, multidisciplinary field that brings together teams of neurosurgeons, otolaryngology-head and neck surgeons (OHNS), plastic surgeons, ophthalmologists, radiation oncologists others. However, not long ago the nascent was instead characterized by isolated individual brilliance. This paper explores contributions several key players towards breaking silos transforming into what it today. Our analysis centers on formation North American Base Society...
<title>Abstract</title> Research in AI for Science often focuses on using modern technologies to augment components of the scientific process<sup>1</sup>, or some cases, entire method<sup>2</sup>; how about publications<sup>3,4</sup>? Peer-reviewed journals are foundational repositories specialized knowledge, written discipline-specific language that differs significantly from general Internet content used train most large models (LLMs) and vision-language (VLMs). We hypothesized by...
Introduction: Endoscopic endonasal approach (EEA) has been increasingly used for resection of anterior skull base meningiomas as an alternative to or in conjunction with open microsurgical resection. The direct the planum sphenoidale avoids frontal lobe retraction and allows early devascularization lesion, though risk postoperative CSF leak is a limitation. We present case 60-year-old female progressively worsening memory, personality changes, loss smell, found have large meningioma...
INTRODUCTION: TERT-promoter (TERTp) mutation in meningiomas is associated with worse prognosis and a biomarker of WHO grade 3 meningioma the 2021 World Health Organization CNS Tumor Classification. METHODS: We analyzed clinical molecular data 563 from eleven institutions next-generation TERTp sequencing. Chromosomal copy number (CN) was obtained microarray or derived DNA methylation. RESULTS: 55 were TERTp-mutant 508 TERTp-wildtype (n=27 3). Of cases, 51% men, median age 66 (range 47-85)...
INTRODUCTION: Benign thyroid goiters can grow to substantial size and cause clinical symptoms related mass effect on critical mediastinal structures. Surgery carry significant morbidity with large lesions, which often extend into the substernal or retrosternal space. Endovascular treatment is a minimally invasive alternative strategy. METHODS: We reviewed EMR of 9 patients bilateral nodular goiter referred for neurosurgical endovascular embolization at NYU Langone Health between 2023-2024....
Retrospective database study.To analyze the economic and age data concerning primary revision posterolateral fusion (PLF) posterior/transforaminal lumbar interbody (PLIF/TLIF) throughout United States to improve value-based care health utilization.The National Inpatient Sample (NIS) was queried by International Classification of Diseases, Ninth Revision, Clinical Modification codes for patients who underwent or PLF PLIF/TLIF between 2011 2014. Age included number procedures, costs, burden....
Abstract Introduction Skull base surgery has evolved from fundamental elements into a distinct multidisciplinary specialty. Using bibliometrics, we appraised the literature pertaining to skull since 1900 and studied emergence of specialty as scholarly field. Methods We queried Web Science for all content past presidents North American Base Society (N = 31) their self-identified forebears, influences, contemporaries, trainees 115). Statistical bibliometric analyses were performed using...