A5055099359- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Cytomegalovirus and herpesvirus research
- Glioma Diagnosis and Treatment
- Immune cells in cancer
- Synthesis and Biological Evaluation
- Extracellular vesicles in disease
- Gastrointestinal disorders and treatments
- Autoimmune and Inflammatory Disorders
- Nanoplatforms for cancer theranostics
- Radiation Therapy and Dosimetry
- Single-cell and spatial transcriptomics
- Liver Disease Diagnosis and Treatment
- Advanced Biosensing Techniques and Applications
- Colorectal Cancer Screening and Detection
- Pancreatitis Pathology and Treatment
- Brain Metastases and Treatment
- Metabolism, Diabetes, and Cancer
- Immunotherapy and Immune Responses
National Institutes of Health
2021-2024
Baylor College of Medicine
2023-2024
National Cancer Institute
2021-2023
Center for Cancer Research
2021-2023
ORCID
2022
Brigham and Women's Hospital
2021-2022
Harvard University
2021-2022
Mucosal-associated invariant T (MAIT) cells are MR1-restricted innate-like that recognize non-peptide antigens including riboflavin derivates. Although in vitro-activated MAIT show antitumor activity, the vivo role of cancer is still unclear. Here, we have shown function when activated by a combination synthetic synthesis pathway-derived antigen 5-OP-RU [5-(2-oxopropylideneamino)-6-D-ribitylaminouracil] and Toll-like receptor 9 (TLR9) agonist CpG. Coadministration CpG induced strong systemic...
ABSTRACT Extraintestinal manifestations of inflammatory bowel disease occur commonly and can lead to considerable morbidity. Pancreatic have been reported be more common in Crohn's (CD) than ulcerative colitis. We report a case granulomatous inflammation the body pancreas with exocrine pancreatic insufficiency, which prompted diagnosis switch from colitis CD. This is interest readers remind them that are
ABSTRACT Glioblastoma, the most common primary brain malignancy, is invariably fatal. Systemic chemotherapy ineffective mostly because of drug delivery limitations. To overcome this, we devised an internalized pump-catheter system for direct chronic convection-enhanced (CED) into peritumoral tissue. Topotecan (TPT) by CED in 5 patients with refractory glioblastoma selectively eliminated tumor cells without toxicity to normal brain. Large, stable distribution volumes were non-invasively...
Abstract Introduction: Hepatocellular Carcinoma (HCC) is a leading cause of cancer-related death and can be considered prototype inflammation-derived cancer arising from chronic liver injury. The cell composition the HCC tumor immune microenvironment (TiME) has major impact on biology as TME have divergent capacities initiation, progress, response to therapy. Recent development multi-omics single-cell technologies help us comprehensively quantify cellular heterogeneity spatial organization...
<div>Abstract<p>Mucosal-associated invariant T (MAIT) cells are MR1-restricted innate-like that recognize non-peptide antigens including riboflavin derivates. Although <i>in vitro</i>–activated MAIT show antitumor activity, the vivo</i> role of in cancer is still unclear. Here, we have shown function when activated by a combination synthetic synthesis pathway–derived antigen 5-OP-RU [5-(2-oxopropylideneamino)-6-D-ribitylaminouracil] and Toll-like receptor 9...
<div>Abstract<p>Mucosal-associated invariant T (MAIT) cells are MR1-restricted innate-like that recognize non-peptide antigens including riboflavin derivates. Although <i>in vitro</i>–activated MAIT show antitumor activity, the vivo</i> role of in cancer is still unclear. Here, we have shown function when activated by a combination synthetic synthesis pathway–derived antigen 5-OP-RU [5-(2-oxopropylideneamino)-6-D-ribitylaminouracil] and Toll-like receptor 9...
<p>Supplementary Figure Legends, S1 and S2</p>
<p>Supplementary Figure Legends, S1 and S2</p>
Introduction: Studies have shown that a higher adenoma detection rate (ADR) decreases the incidence of interval colorectal cancer diagnosis. Artificial intelligence (AI) in colonoscopy is an emerging tool to increase ADR, sessile serrated lesion (SSLs) and polyp (PDR). Methods: The AI device, GI Genius by Medtronic, was obtained through Health Equity Assistance Program from American Society Gastrointestinal Endoscopy. device implemented endoscopy center November 2022. Given colonoscopies at...
Abstract Background: Checkpoint blockade immunotherapy (CBI) can induce a durable response for some patients with hepatic tumors, but many derive no or incomplete oncologic benefit unclear reasons. Regulatory T cells (Tregs) in the liver play central role maintaining tolerogenic local immune environment, both homeostasis and disease. Here we sought to explore impact of CBI on Tregs determine if they resistance tumors mice. Methods: High-dimensional flow cytometry was used examine ex vivo...
Abstract Introduction Mucosal-associated invariant T (MAIT) cells are MR1-resricted innate-like that recognize non-peptide antigens including riboflavin derivates. They can be detected in both primary tumors and metastasis, yet their role cancer is still unclear. In vitro activated MAIT have demonstrated anti-tumor activity suggesting potential for immunotherapy, but vivo data lacking. Experimental procedures We systemically administered a combination of the VitaminB2 synthesis...
<h3>Background</h3> MAIT cells are MR1-restricted innate-like T that recognize non-peptide antigens including riboflavin derivates. They account for up to 10 % of circulating cells, but they further enriched at mucosal sites and the liver. On one hand, altered number function have been reported in liver cancer with MAITs correlating poor clinical outcome. other we recently demonstrated can potentially anti-tumor activity suggesting them as a novel target immunotherapy. Yet, cellular humoral...