A5087106857- Glioma Diagnosis and Treatment
- Neuroscience and Neuropharmacology Research
- Histone Deacetylase Inhibitors Research
- Neural dynamics and brain function
- Brain Metastases and Treatment
- Neuroscience and Neural Engineering
- MRI in cancer diagnosis
- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Spine and Intervertebral Disc Pathology
- Radiomics and Machine Learning in Medical Imaging
- Neuroblastoma Research and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Melanoma and MAPK Pathways
- Receptor Mechanisms and Signaling
- Ocular Oncology and Treatments
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- History of Medical Practice
- Protein Degradation and Inhibitors
- RNA Research and Splicing
- Vascular Tumors and Angiosarcomas
- S100 Proteins and Annexins
Neurological Surgery
2016-2025
Columbia University Irving Medical Center
2013-2025
Columbia University
2016-2025
Memorial Sloan Kettering Cancer Center
2022
University of Colorado Anschutz Medical Campus
2017
Cancer Research Center
2017
Texas Tech University Health Sciences Center
2008-2009
Texas Tech University
2005-2009
Mayo Clinic
1993
Background: The geometry of the tibial plateau is complex and asymmetric. Previous research has characterized subject-to-subject differences in sagittal plane on basis a single parameter, posterior slope. We hypothesized that (1) there are large variations terms slopes, depth concavity medial plateau, extent convexity lateral plateau; (2) slope different within subjects; (3) sex-based slopes as well concavities convexities (4) age not associated with any measured parameters. Methods: medial,...
✓ A total of 93 patients with intractable spasticity due to either spinal cord injury (59 cases), multiple sclerosis (31 or other pathology (three cases) were entered into a randomized double-blind placebocontrolled screening protocol intrathecal baclofen test injections. Of the 88 who responded an bolus 50, 75, 100 µg baclofen, 75 underwent implantation programmable pump system for chronic therapy. Patients followed 5 41 months after surgery (mean 19 months). No deaths new permanent...
Background The geometry of the tibial plateau has been largely ignored as a source possible risk factors for anterior cruciate ligament injury. Discovering injury associated with may lead to delineation existing sex-based disparity in injuries and help develop strategies prevention regardless gender. Hypothesis Individuals shallower medial depth concavity, while having increased posteriorly directed slope their plateau, are at suffering an compared those decreased posterior depth....
Significance Molecular analysis of surgically resected glioblastomas (GBM) samples has uncovered phenotypically and clinically distinct tumor subtypes. However, little is known about the molecular features glioma margins that are left behind after surgery. To address this key issue, we performed RNA-sequencing (RNA-seq) histological on MRI-guided biopsies from contrast-enhancing core nonenhancing GBM. Computational deconvolution RNA-seq data revealed cellular composition, including...
<h3>BACKGROUND AND PURPOSE:</h3> The complex MR imaging appearance of glioblastoma is a function underlying histopathologic heterogeneity. A better understanding these correlations, particularly the influence infiltrating glioma cells and vasogenic edema on T2 diffusivity signal in nonenhancing areas, has important implications management patients. With localized biopsies, objective this study was to generate model capable predicting cellularity at each voxel within an entire tumor volume as...
Glioblastoma (GBM) diffusely infiltrates the brain and intermingles with non-neoplastic cells, including astrocytes, neurons microglia/myeloid cells. This complex mixture of cell types forms biological context for therapeutic response tumor recurrence. We used single-nucleus RNA sequencing spatial transcriptomics to determine cellular composition transcriptional states in primary recurrent glioma identified three compositional 'tissue-states' defined by cohabitation patterns between specific...
Glioblastoma (GBM) classification involves a combination of histological and molecular signatures including IDH1/2 mutation, TERT promoter EGFR amplification. Non-canonical mutations such as BRAFV600E, found in 1–2% GBMs, activate the MEK-ERK signaling pathway. This mutation can be targeted by small molecule inhibitors, offering therapeutic potential for GBM. In this case report, we describe management 67-year-old male with BRAFV600E -mutant GBM, who experienced both local clonal distant...
Abstract Purpose: While MGMT promoter methylation (mMGMT) is predictive of response to alkylating chemotherapy and guides treatment decisions in glioblastoma, its role grade 2 3 glioma remains unclear. Recent data suggest that mMGMT prognostic progression-free survival 1p/19q-codeleted oligodendrogliomas, but an effect on overall (OS) has not been demonstrated. Experimental Design: We identified patients with newly diagnosed gliomas known status the National Cancer Database from 2010 2019....
Highlights•Tsc1-null late embryonic RGCs generate cytomegalic pyramidal neurons (CPNs)•CPNs are synaptically hyperexcitable and susceptible to seizure-like activities•Enhanced synaptic excitation in CPNs contributes epileptogenesis•Astrocyte gliosis evolves secondary recurrent seizuresSummaryTuberous sclerosis complex (TSC) is a developmental disorder associated with epilepsy, autism, cognitive impairment. Despite inactivating mutations the TSC1 or TSC2 genes hyperactive mechanistic target...
Accurate tissue sampling in nonenhancing (NE) gliomas is a unique surgical challenge due to their intratumoral histological heterogeneity and absence of contrast enhancement as guide for intraoperative stereotactic guidance. Instead, T2/fluid-attenuated inversion-recovery (FLAIR) hyperintensity on MRI commonly used an imaging surrogate pathological tissue, but from this region can yield nondiagnostic or underdiagnostic brain tissue. Sodium fluorescein fluorescent dye that has high predictive...
Standard-of-care first-line therapy for patients with newly diagnosed glioblastoma (ndGBM) is maximal safe surgical resection, then concurrent radiotherapy and temozolomide, followed by maintenance temozolomide. IGV-001, the first product of Goldspire™ platform, a first-in-class autologous immunotherapeutic that combines personalized whole tumor–derived cells an antisense oligonucleotide (IMV-001) in implantable biodiffusion chambers, intent to induce tumor-specific immune response ndGBM....
Gliomas are highly aggressive brain tumors characterized by poor prognosis and composed of diffusely infiltrating tumor cells that intermingle with non-neoplastic in the microenvironment, including neurons. Neurons increasingly appreciated as important reactive components glioma due to their role causing hallmark symptoms, such cognitive deficits seizures, well potential ability drive progression. Separately, mTOR signaling has been shown have pleiotropic effects regulation neuronal...
Abstract While several studies have attributed the development of tumour-associated seizures to an excitatory-inhibitory imbalance, we yet resolve spatiotemporal interplay between different types neuron in glioma-infiltrated cortex. Herein, combined methods for single unit analysis microelectrode array recordings with wide-field optical mapping Thy1-GCaMP pyramidal cells ex vivo acute slice model diffusely infiltrating glioma. This enabled simultaneous tracking individual neurons from both...
<h3>BACKGROUND AND PURPOSE:</h3> Malignant glioma is a highly infiltrative malignancy that causes variable disruptions to the structure and function of cerebrovasculature. While many these structural have known correlative histopathologic alterations, mechanisms underlying vascular dysfunction identified by resting-state blood oxygen level–dependent imaging are not yet known. The purpose this study was characterize alterations correlate with biomarker dysregulation. <h3>Materials...
The purpose of this study is to develop a platform in which the cellular and molecular underpinnings chronic focal neocortical lesional epilepsy can be explored use it characterize seizure-like events (SLEs) an ex vivo model infiltrating high-grade glioma. Microelectrode arrays were used electrophysiologic changes acute brain slices from PTEN/p53 deleted, PDGF-B driven mouse Electrode locations co-registered underlying histology ascertain influence varying histologic landscape on observed...
Abstract INTRODUCTION Many glioblastoma (GBM) treatments fail because they treat tumor cells in isolation and ignore the surrounding microenvironment. In our phase 1b clinical trial of delivery Topotecan (TPT) via Convection Enhanced Delivery (CED) glioma, we demonstrated effective cell elimination accompanied by a robust inflammatory response. We hypothesized that TPT induces an immunogenic response resulting unfavorable landscape. METHODS To characterize chemotherapy’s effect on myeloid...
Abstract Standard of care (SOC) for ndGBM begins with maximal safe resection followed by adjuvant radiotherapy and temozolomide, maintenance temozolomide. IGV-001 is an autologous biologic-device combination immunotherapy the treatment that consists GBM tumor cells antisense oligonucleotide against IGF-1R mRNA, irradiated administered via biodiffusion chambers implanted in abdomen. In a phase 1b study, was well tolerated without unexpected adverse events subjects ndGBM. Multiple efficacy...
Abstract Dexamethasone is the most widely utilized drug for glioblastoma (GBM). However, systemic delivery of dexamethasone in GBM patients associated with significant side effects and increasing doses worse survival. Convection-enhanced (CED) can deliver high immunotherapy directly into tumor microenvironment (TME) while avoiding toxicity. Here, we report that be delivered locally by CED without increase survival a model along reduced inflammatory myeloid signatures. We investigated...