A5026350256- Carcinogens and Genotoxicity Assessment
- Radio Astronomy Observations and Technology
- Astrophysics and Cosmic Phenomena
- Free Radicals and Antioxidants
- DNA and Nucleic Acid Chemistry
- Antenna Design and Optimization
- Effects and risks of endocrine disrupting chemicals
- Analytical Chemistry and Chromatography
- Toxic Organic Pollutants Impact
- Radio Wave Propagation Studies
- Chemical Reaction Mechanisms
- DNA Repair Mechanisms
- Eicosanoids and Hypertension Pharmacology
- Galaxies: Formation, Evolution, Phenomena
- Pharmacogenetics and Drug Metabolism
- Coenzyme Q10 studies and effects
- Cancer, Hypoxia, and Metabolism
- Synthesis of Organic Compounds
- Soil Moisture and Remote Sensing
- Superconducting and THz Device Technology
- Neuroscience and Neuropharmacology Research
- Molecular Sensors and Ion Detection
- Biochemical Acid Research Studies
- Electromagnetic Compatibility and Measurements
- Genomics, phytochemicals, and oxidative stress
Arizona State University
2022-2025
McGill University
2021-2025
Columbia University
2013-2024
University of Pennsylvania
2024
Space Science Institute
2024
Brown University
2017-2023
Queen Mary University of London
2021
National Radio Astronomy Observatory
2020
Oxford University Press (United Kingdom)
2020
EIA University
2020
Research Article| June 01 1961 An enzyme from rat liver catalysing conjugations with glutathione J. Booth; Booth 1Chester Beatty Institute, Institute of Cancer Research; Royal Hospital, Fulham Road, London, S.W. 3 Search for other works by this author on: This Site PubMed Google Scholar E. Boyland; Boyland P Sims Biochem J (1961) 79 (3): 516–524. https://doi.org/10.1042/bj0790516 Connected Content A correction has been published: Views Icon Article contents Figures & tables Video Audio...
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Research Article| November 01 1968 Enzyme-catalysed reactions of polycyclic hydrocarbons with deoxyribonucleic acid and protein in vitro P L Grover; Grover 1Chester Beatty Institute, Institute Cancer Research: Royal Hospital, London, S. W. 3 Search for other works by this author on: This Site PubMed Google Scholar Sims Biochem J (1968) 110 (1): 159–160. https://doi.org/10.1042/bj1100159 Views Icon Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Facebook...
Abstract We report upper limits on the Epoch of Reionization 21 cm power spectrum at redshifts 7.9 and 10.4 with 18 nights data (∼36 hr integration) from Phase I Hydrogen Array (HERA). The show evidence for systematics that can be largely suppressed systematic models down to a dynamic range ∼10 9 respect peak foreground power. This yields 95% confidence limit <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" overflow="scroll"> <mml:msubsup> <mml:mrow> <mml:mi...
Abstract Recently, the Hydrogen Epoch of Reionization Array (HERA) has produced experiment’s first upper limits on power spectrum 21 cm fluctuations at z ∼ 8 and 10. Here, we use several independent theoretical models to infer constraints intergalactic medium (IGM) galaxies during epoch reionization from these limits. We find that IGM must have been heated above adiabatic-cooling threshold by 8, uncertainties about ionization radio background. Combining HERA with complementary observations...
Abstract We report the most sensitive upper limits to date on 21 cm epoch of reionization power spectrum using 94 nights observing with Phase I Hydrogen Epoch Reionization Array (HERA). Using similar analysis techniques as in previously reported limits, we find at 95% confidence that Δ 2 ( k = 0.34 h Mpc −1 ) ≤ 457 mK z 7.9 and 0.36 3496 10.4, an improvement by a factor 2.1 2.6, respectively. These are mostly consistent thermal noise over wide range after our data quality cuts, despite...
K-region epoxides of the carcinogens benz[a] anthracene, dibenz[a,h]anthracene, and 7-methylbenz[a] anthracene are mutagenic in strains Salmonella typhimurium designed to detect frameshift mutagens. Parent hydrocarbons, diols phenols some other inactive as mutagens these tests. Polycyclic hydrocarbon epoxides, presumed proximal carcinogens, discussed examples intercalating agents with reactive side chains. It has been shown previously that chains potent
The K-region epoxides and cis-dihydrodiols derived from benz(a)anthracene dibenz(a,h)-anthracene have been found to be more active in the production of malignant transformation hamster embryo cells than hydrocarbons or corresponding phenols. benz(a)-anthracene 3-methylcholanthrene were also transforming a clone ventral prostate C3H mouse that was not readily transformed by parent hydrocarbons. phenols most toxic compounds tested but did transform cells; this confirms toxicity are directly...
The cytotoxicity and mutagenicity of several polycyclic hydrocarbons their K-region derivatives were tested in a clone Chinese hamster cells; the production clones resistant to 8-azaguanine was used as marker for mutagenesis. In series related benz(a)anthracene, epoxide highly mutagenic, phenol less mutagenic; hydrocarbon cis trans-dihydrodiols not mutagenic. Seven isolated retained drug-resistance; three these could be reverted wild type. There no difference chromosome numbers among parent...
1. The main products of the metabolism 7,12-dimethylbenz[a]anthracene by rat-liver homogenates are isomeric monohydroxymethyl derivatives. syntheses these compounds described. 2. Two phenolic and two dihydrodihydroxy were formed, but none appeared to have been formed hydroxylation at ;K region'. There was little evidence for formation a glutathione conjugate hydrocarbon. 3. derivatives hydrocarbon in ascorbic acid-Fe(2+)-oxygen model hydroxylating system.
1. Benz[a]anthracene was hydroxylated by rat-liver homogenates on the 3,4-,5,6- or 8,9-bond to yield phenols and dihydrodihydroxy compounds. Metabolic action at 7- 12-positions also detected. 5,6-Epoxy-5,6-dihydrobenzanthracene converted into a phenol that is probably 5-hydroxybenzanthracene 5,6-dihydro-5,6-dihydroxybenzanthracene. Both substrates yielded product S-(5,6-dihydro-6-hydroxy-5-benzanthracenyl)glutathione. 2. Dibenz[a,h]anthracene products are 3- 4-hydroxydibenzanthracene,...
ABSTRACT Cosmic Dawn (CD), when the first stars and proto-galaxies began to form, is commonly expected be accompanied by an absorption signature at radio frequencies. This feature arises as Lyman α photons emitted these luminous objects couple 21 cm excitation temperature of intergalactic hydrogen gas its kinetic temperature, driving it into relative cosmic microwave background. The detailed properties this profile encode powerful information about physics CD. Recently, Bowman et al....