A5002818045- Carcinogens and Genotoxicity Assessment
- DNA and Nucleic Acid Chemistry
- Effects and risks of endocrine disrupting chemicals
- Free Radicals and Antioxidants
- Toxic Organic Pollutants Impact
- Analytical Chemistry and Chromatography
- DNA Repair Mechanisms
- Eicosanoids and Hypertension Pharmacology
- Genomics, phytochemicals, and oxidative stress
- Glutathione Transferases and Polymorphisms
- Chemical Reactions and Isotopes
- Click Chemistry and Applications
- Synthesis of Organic Compounds
- Pharmacogenetics and Drug Metabolism
- Cancer, Hypoxia, and Metabolism
- Biochemical Analysis and Sensing Techniques
- Synthesis and Biological Evaluation
- Coenzyme Q10 studies and effects
- Inorganic and Organometallic Chemistry
- Prion Diseases and Protein Misfolding
- Biological Activity of Diterpenoids and Biflavonoids
- Estrogen and related hormone effects
- Chronic Myeloid Leukemia Treatments
- Molecular Sensors and Ion Detection
- Chemical Reaction Mechanisms
Ruhr University Bochum
2023-2024
University of Pittsburgh
2014-2015
Institute of Cancer Research
1983-2002
University of Ulster
1970-1986
Royal Victoria Hospital
1970-1986
Balfour Beatty (United Kingdom)
1963-1982
Medical Research Council
1980
Ludwig Cancer Research
1980
MRC Toxicology Unit
1980
Portsmouth College
1979
Research Article| November 01 1968 Enzyme-catalysed reactions of polycyclic hydrocarbons with deoxyribonucleic acid and protein in vitro P L Grover; Grover 1Chester Beatty Institute, Institute Cancer Research: Royal Hospital, London, S. W. 3 Search for other works by this author on: This Site PubMed Google Scholar Sims Biochem J (1968) 110 (1): 159–160. https://doi.org/10.1042/bj1100159 Views Icon Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Facebook...
K-region epoxides of the carcinogens benz[a] anthracene, dibenz[a,h]anthracene, and 7-methylbenz[a] anthracene are mutagenic in strains Salmonella typhimurium designed to detect frameshift mutagens. Parent hydrocarbons, diols phenols some other inactive as mutagens these tests. Polycyclic hydrocarbon epoxides, presumed proximal carcinogens, discussed examples intercalating agents with reactive side chains. It has been shown previously that chains potent
DNA has been isolated from human bronchial segments that have treated in short-term organ culture with 3H-labelled benzo (a) pyrene. also mouse skin samples of pyrene, the related radioactive 4,5-, 7,8- and 9,10-dihydrodiols 3H-3-hydroxybenzo Sephadex LH20 column chromatography hydrolysates these showed hydrocarbondeoxyribonucleoside products formed (a)-pyrene-treated mucosa are indistinguishable those when 7,8-dihydro-7,8-dihydroxybenzo pyrene 9,10-oxide reacts solution. These same...
Abstract NEMO is a ubiquitin-binding protein which regulates canonical NF-κB pathway activation in innate immune signaling, cell death regulation and host-pathogen interactions. Here we identify an NF-κB-independent function of proteostasis by promoting autophagosomal clearance aggregates. NEMO-deficient cells accumulate misfolded proteins upon proteotoxic stress are vulnerable to challenges. Moreover, patient with mutation the NEMO-encoding IKBKG gene resulting defective binding linear...
Epidemiological evidence suggests a link between meat consumption and prostate cancer. In this study, benign prostatic hyperplasia tissues, obtained by transurethral resection or radical retropubic prostatectomy from UK-resident individuals (n = 18), were examined for CYP1 expression their ability, in short-term organ culture, to metabolically activate carcinogens found cooked meat. Semi-quantitative RT–PCR analysis of detected CYP1A2 mRNA transcripts the prostates four individuals, as well...
Heterocyclic aromatic amines (HAAs), formed during the cooking of foods, are known to induce tumours in rodent bioassays and may thus contribute human cancer risk. We tested six HAAs a morphological transformation assay three vitro genotoxicity assays. The transforming abilities were tested, presence rat-liver S9, C3H/M2 fibroblast cell line. Concentration levels 50 microM 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (8-MeIQx), 100 2-amino-3,4,8-trimethylimidazo-[4,5-f]quinoxaline...