A5028468367- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Ferroptosis and cancer prognosis
- Nanoplatforms for cancer theranostics
- CAR-T cell therapy research
- Cancer-related molecular mechanisms research
- Radiopharmaceutical Chemistry and Applications
- T-cell and B-cell Immunology
- Immune cells in cancer
- Metal-Organic Frameworks: Synthesis and Applications
- Peptidase Inhibition and Analysis
- Atherosclerosis and Cardiovascular Diseases
- Magnetism in coordination complexes
- Chemical Synthesis and Analysis
- Machine Learning in Materials Science
- Phagocytosis and Immune Regulation
- Lanthanide and Transition Metal Complexes
- Prostate Cancer Treatment and Research
National Cancer Institute
2023-2024
National Institutes of Health
2023-2024
Rochester Institute of Technology
2019-2024
Center for Cancer Research
2023
A practical, convergent synthesis of prostate-specific membrane antigen (PSMA) targeted imaging agents for MRI, PET, and SPECT prostate cancer has been developed. In this approach, metals chelated to 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) were placed on the side chains lysine early in form modules. These are coupled targeting modules, case consisting PSMA-binding urea DCL, bonded an activated linker. The modular approach molecular (TMIAs) offers distinct advantages....
Abstract The major focus of cancer immunotherapy has been on conventional T cells due to their unique recognition specific peptide antigens. Despite advances in the field, including use atezolizumab and bevacizumab as first-line therapy for unresectable hepatocellular carcinoma (HCC), overall mortality rate HCC continues rise. Innate lymphoid (ILC) innate-like (ILTC) are broadly categorized within innate population playing an important role inflammation, tissue repair immune tolerance. Their...
Abstract Concentration‐dependent increases in relaxivity (r1) were found to be induced by self‐assembly when Fmoc is adjacent tryptophan peptide‐based MRI contrast agents featuring Gd‐DOTA. A series of di‐ and tri‐peptides synthesized test the effect ionic strength, N‐terminal substituent, peptide length, net charge, relative location on r1 critical aggregation concentration (CAC) at 1.0 Tesla. Compared nominal values 3.5–7.4 mM −1 s per Gd(III), increased dramatically 13.2–16.9 Gd(III) upon...
Introduction The cellular composition of the hepatocellular carcinoma (HCC) tumor microenvironment (TME) has major impact on initiation, progress, and therapy response. Mucosal-associated invariant T (MAIT) are an abundant cell subtype in human liver play a crucial role regulating immunity inflammation. Yet, their HCC potential for cancer immunotherapy remains elusive.