A5037235279- RNA Interference and Gene Delivery
- Artificial Intelligence in Healthcare and Education
- Tissue Engineering and Regenerative Medicine
- Neuroscience and Neural Engineering
- Cardiac Fibrosis and Remodeling
- Toxin Mechanisms and Immunotoxins
- Mitochondrial Function and Pathology
- Microbial Inactivation Methods
- Machine Learning in Healthcare
- Cardiac Ischemia and Reperfusion
- Electrostatic Discharge in Electronics
- 3D Printing in Biomedical Research
- Topic Modeling
- Intensive Care Unit Cognitive Disorders
- Extracellular vesicles in disease
- Acute Myocardial Infarction Research
- GDF15 and Related Biomarkers
- Long-Term Effects of COVID-19
- Biomedical Text Mining and Ontologies
- Mechanical Circulatory Support Devices
- Virus-based gene therapy research
- Cardiovascular Function and Risk Factors
- Wikis in Education and Collaboration
- Bariatric Surgery and Outcomes
- Congenital heart defects research
Hinge Health
2025
Universidade Federal do Espírito Santo
2024
Mayo Clinic in Arizona
2017-2024
NYU Langone Health
2023
Mayo Clinic
2016-2021
WinnMed
2016-2021
Abstract Physicians make critical time-constrained decisions every day. Clinical predictive models can help physicians and administrators by forecasting clinical operational events. Existing structured data-based have limited use in everyday practice owing to complexity data processing, as well model development deployment 1–3 . Here we show that unstructured notes from the electronic health record enable training of language models, which be used all-purpose engines with low-resistance...
Background: Reentrant ventricular arrhythmias are a major cause of sudden death in patients with structural heart disease. Current treatments focus on electrically homogenizing regions scar contributing to arrhythmia ablation or altering conductive properties using antiarrhythmic drugs. The high conductivity carbon nanotubes may allow restoration conduction where impaired electrical results functional abnormalities. We propose new concept for treatment stretchable, flexible biopatch attempt...
Background The Purkinje network appears to play a pivotal role in the triggering as well maintenance of ventricular fibrillation. Irreversible electroporation ( IRE ) using direct current has shown promise nonthermal ablation modality heart, but its ability target and ablate tissue is undefined. Our aim was investigate potential for selective Purkinje/fascicular fibers . Methods Results In an ex vivo Langendorff model canine heart (n=8), delivered unipolar manner at various dosages from 750...
<title>Abstract</title> Research in AI for Science often focuses on using modern technologies to augment components of the scientific process<sup>1</sup>, or some cases, entire method<sup>2</sup>; how about publications<sup>3,4</sup>? Peer-reviewed journals are foundational repositories specialized knowledge, written discipline-specific language that differs significantly from general Internet content used train most large models (LLMs) and vision-language (VLMs). We hypothesized by...
The purpose of this study was to investigate a therapeutic approach targeting the inflammatory response and consequent remodeling from ischemic myocardial injury.
Introduction The application of brief high voltage electrical pulses to tissue can lead an irreversible or reversible electroporation effect in a cell-specific manner. In the management ventricular arrhythmias, ability target different types, specifically cardiac conduction (His-Purkinje System) vs. myocardium would be advantageous. We hypothesize that pulsed electric fields (PEFs) applied safely beating heart through catheter-based approach, and we tested whether superficial Purkinje cells...
Background: The nerve autograft remains the gold standard when reconstructing peripheral defects. However, although repair can result in useful functional recovery, poor outcomes are common, and better treatments needed. purpose of this study was to evaluate effect purified exosome product on motor recovery nerve-related gene expression a rat sciatic reverse model. Methods: Ninety-six Sprague-Dawley rats were divided into three experimental groups. In each group, unilateral 10-mm defect...
The M
Diabetes mellitus type 2 (DM2) remission after bariatric surgery has long been reported in the medical literature. Glucocorticoid use is associated with weight gain and could theoretically affect diabetes post surgery.The aim to identify rates of DM2 among patients using glucocorticoids assess long-term postsurgical follow-up.A retrospective analysis was performed on who used underwent at Mayo Clinic between 2008 2020. Data were analyzed for 3-month, 6-month, 1-year, 2-year, 5-year intervals...
Therapies for substrate-related arrhythmias include ablation or drugs targeted at altering conductive properties disruption of slow zones in heterogeneous myocardium. Conductive compounds such as carbon nanotubes may provide a novel personalizable therapy arrhythmia treatment by allowing tissue homogenization.A nanocellulose nanotube-conductive hydrogel was developed to have conduction similar normal Ex vivo perfused canine hearts were studied. Electroanatomic activation mapping the...
Abstract Stem cell paracrine activity is implicated in cardiac repair. Linkage between secretome functionality and therapeutic outcome was here interrogated by systems analytics of biobanked human cardiopoietic cells, a regenerative biologic advanced clinical trials. Protein chip array identified 155 proteins differentially secreted cells with benefit, expanded into 520 node network, collectively revealing inherent vasculogenic properties along smooth muscle differentiation development. Next...
INTRODUCTION: Existing clinical prediction algorithms mostly leverage small cohorts of structured data (e.g., medical imaging or laboratory data). However, large language models have demonstrated the ability to utilize unstructured outperform other machine learning approaches given sufficient data. Training on notes offers a possible alternative algorithm development in tasks. METHODS: An unlabeled dataset over seven million radiology reports and patient histories) was collected from four...