A5038481242- Multiple Myeloma Research and Treatments
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Histone Deacetylase Inhibitors Research
- Cancer Mechanisms and Therapy
- Bone health and treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cytokine Signaling Pathways and Interactions
- Cardiovascular Disease and Adiposity
- Bone Metabolism and Diseases
- Acute Myeloid Leukemia Research
- Diabetes and associated disorders
- COVID-19 Clinical Research Studies
- Chemokine receptors and signaling
- Ubiquitin and proteasome pathways
- Phagocytosis and Immune Regulation
- Cancer-related gene regulation
- Immune Cell Function and Interaction
- Adipokines, Inflammation, and Metabolic Diseases
- Pancreatic function and diabetes
- RNA Interference and Gene Delivery
- Circular RNAs in diseases
- Long-Term Effects of COVID-19
- Cancer Treatment and Pharmacology
- SARS-CoV-2 and COVID-19 Research
Institute for Experimental Endocrinology and Oncology
2019-2021
National Research Council
2020-2021
MultiMedica
2018-2020
Istituti di Ricovero e Cura a Carattere Scientifico
2020
University of Milan
2013-2019
University of Verona
1986
Innovative biomarkers are needed to improve the management of patients with type 2 diabetes mellitus (T2DM). Blood circulating miRNAs have been proposed as a potential tool detect T2DM complications, but lack tissue specificity, among other reasons, has hampered their translation clinical settings. Extracellular vesicle (EV)-shuttled an alternative approach. Here, we adapted immunomagnetic bead-based method isolate plasma CD31+ EVs harvest vesicles deriving from tissues relevant for...
// Michela Colombo 1 , Katja Thümmler 2 Leonardo Mirandola Silvia Garavelli Katia Todoerti 6 Luana Apicella Elisa Lazzari Marialuigia Lancellotti Natalia Platonova Moeed Akbar Maurizio Chiriva-Internati 4 Richard Soutar 5 Antonino Neri 3 Carl S. Goodyear and Raffaella Chiaramonte Department of Health Sciences, Università degli Studi di Milano, Italy Institute Infection, Immunity Inflammation, College Medical, Veterinary Life University Glasgow, UK Clinical Sciences Community Health, Milano;...
Multiple myeloma cell growth relies on intrinsic aggressiveness, due to a high karyotypic instability, or the support from bone marrow (BM) niche.We and other groups have provided evidences that Notch signaling is related tumor growth, pharmacological resistance, localization/recirculation in BM disease.This study indicates gene expression levels of members (JAG1, NOTCH2, HES5 HES6) correlate with malignant progression high-risk disease, may participate by increasing interleukin-6 (IL-6),...
Immune cell subsets and microRNAs have been independently proposed as type 1 diabetes (T1D) diagnostic and/or prognostic biomarkers. Here, we aimed to analyze the relationships between peripheral blood circulating immune subsets, plasmatic microRNAs, T1D. Blood samples were obtained from both children with T1D at diagnosis age-sex matched healthy controls. Then, immunophenotype assessed by flow cytometry was coupled quantification of 60 quantitative RT-PCR. The associations frequency,...
Multiple myeloma is still incurable due to an intrinsic aggressiveness or, more frequently, the interactions of malignant plasma cells with bone marrow (BM) microenvironment. Myeloma educate BM support neoplastic cell growth, survival, acquisition drug resistance resulting in disease relapse. microenvironment characterized by Notch signaling hyperactivation increased expression Notch1 and 2 ligands Jagged1 tumor cells. activation influences biology promotes reprogramming stromal In this work...
The clinical benefit of convalescent plasma (CP) for patients with coronavirus disease (COVID)-19 is still debated. In this systematic review and meta-analysis, we selected 10 randomized trials (RCTs) 15 non-randomized studies (total number = 22,591) CP treatment evaluated two different scenarios: (1) stage recipients (2) donated antibody titer, considering all-cause mortality at the latest follow-up. Our results show that, when provided early stages disease, significantly reduced mortality:...
The pathways of NOTCH and PI3K/AKT are dysregulated in about 60% 48% T-cell acute lymphoblastic leukemia (T-ALL) patients, respectively. In this context, they interact cooperate controlling tumor cell biology. Here, we propose a novel mechanism by which the pathway regulates NOTCH1 T-ALL, starting from evidence that inhibition signaling induced treatment with LY294002 or transient transfection dominant negative AKT mutant downregulates protein levels activity, without affecting...
The recent advances, offered by cell therapy in the regenerative medicine field, offer a revolutionary potential for development of innovative cures to restore compromised physiological functions or organs. Adult myogenic precursors, such as myoblasts satellite cells, possess marked capacity, but exploitation this still encounters significant challenges clinical application, due low rate proliferation vitro, well reduced self-renewal capacity. In scenario, induced pluripotent stem cells...
MicroRNAs (miRNAs), small non-coding molecules targeting messenger RNAs and inhibiting protein translation, modulate key biological processes, including cell growth development, energy utilization, homeostasis. In particular, miRNAs control the differentiation, survival, activation of CD4 + T conventional (Tconv) cells, players adaptive immunity, regulate physiological response to infections pathological loss immune homeostasis in autoimmunity. Upon T-cell receptor (TCR) stimulation,...
Innovative biomarkers are needed to improve the management of patients with type 2 diabetes mellitus (T2DM). Blood circulating miRNAs have been proposed as a potential tool detect T2DM complications but lack tissue specificity, among other reasons, has hampered their translation clinical settings. Extracellular vesicle (EV)-shuttled an alternative approach. Here, we adapted immunomagnetic bead-based method isolate plasma CD31 positive (<sup>+</sup>) EVs harvest vesicles deriving...