A5036907767- Fatty Acid Research and Health
- Phytochemicals and Antioxidant Activities
- Cholesterol and Lipid Metabolism
- Antioxidant Activity and Oxidative Stress
- Cancer, Lipids, and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Edible Oils Quality and Analysis
- Eicosanoids and Hypertension Pharmacology
- Inflammatory mediators and NSAID effects
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Adipose Tissue and Metabolism
- Cardiovascular Disease and Adiposity
- Periodontal Regeneration and Treatments
- Peroxisome Proliferator-Activated Receptors
- Atherosclerosis and Cardiovascular Diseases
- Bone Tissue Engineering Materials
- Fermentation and Sensory Analysis
- Nutrition, Genetics, and Disease
- Nutritional Studies and Diet
- Pomegranate: compositions and health benefits
- Atrial Fibrillation Management and Outcomes
- Lipoproteins and Cardiovascular Health
- Protease and Inhibitor Mechanisms
- Natural product bioactivities and synthesis
National Research Council
2015-2024
Istituto di Fisiologia Clinica
2015-2024
Czech Academy of Sciences, Institute of Physiology
1998-2024
University of Salento
2010-2024
Magna Graecia University
2024
Azienda Ospedaliera Universitaria Pisana
2019-2024
University of Pisa
1999-2024
Ospedale Versilia
2023
Ospedale generale di zona San Camillo Treviso
2023
Azienda Ospedaliero-Universitaria Careggi
2023
Epidemiology suggests that Mediterranean diets are associated with reduced risk of cardiovascular disease. Because monocyte adhesion to the endothelium is crucial in early atherogenesis, we evaluated whether typical olive oil and red wine polyphenols affect endothelial-leukocyte molecule expression adhesion.Phytochemicals wine, including oleuropein, hydroxytyrosol, tyrosol, elenolic acid, resveratrol, or without antioxidant activity, were incubated human umbilical vein endothelial cells for...
Abstract —Because oleic acid is implicated in the antiatherogenic effects attributed to Mediterranean diet, we investigated whether this fatty can modulate endothelial activation, ie, concerted expression of gene products involved leukocyte recruitment and early atherogenesis. We incubated sodium oleate with human umbilical vein cells for 0 72 hours, followed by coincubation recombinant tumor necrosis factor, interleukin (IL)-1α, IL-1β, IL-4, Escherichia coli lipopolysaccharide (LPS), or...
Anthocyanins, the naturally occurring pigments responsible for most red to blue colours of flowers, fruits and vegetables, have also attracted interest because their potential health effects. With aim contributing major insights into structure-activity relationship (SAR), we evaluated radical scavenging biological activities selected purified anthocyanin samples (PASs) from various anthocyanin-rich plant materials: two (mahaleb cherry blackcurrant) vegetables (black carrot "Sun Black"...
Inflammation of the adipose tissue plays an important role in development several chronic diseases associated with obesity. Polyphenols extra virgin olive oil (EVOO), such as secoiridoids oleocanthal (OC) and oleacein (OA), have many nutraceutical proprieties. However, their roles obesity-associated adipocyte inflammation, NF-κB pathway related sub-networks not been fully elucidated. Here, we investigated impact OC OA on activation expression molecules inflammatory dysmetabolic responses. To...
Psychological distress is recognised as the most common mental health difficulty in emerging adult (18-to-24-year-old) female academic students. This study aimed to test a novel model positing physical activity habits protective factor for psychological through mediating role of and parameters. Adherence Mediterranean diet self-reported status were included Self-reported time spent on leisure activities parameters considered.
Hyperhomocysteinemia is a recognized risk factor for vascular disease, but pathogenetic mechanisms involved in its actions are largely unknown. Because VCAM-1 expression crucial monocyte adhesion and early atherogenesis, we evaluated the NF-kappaB-related induction of by homocysteine (Hcy) possible inhibitory effect dietary polyphenolic antioxidants, such as trans-resveratrol (RSV) hydroxytyrosol (HT), which known inhibitors NF-kappaB-mediated induction. In human umbilical vein endothelial...
Cyclooxygenase (COX)-2 expression is increased in inflammation and angiogenesis also atherosclerotic plaques, where it co-localizes with metalloproteinases (MMPs) involved the fibrous cap weakening. Insight into regulation of COX-2 MMP-9 suggests involvement a Rho-dependent pathway. Because statins interfere Rho activation, we investigated statin effect on MMP expressions human endothelium. Simvastatin atorvastatin were incubated endothelial cells for 12 h before stimulation phorbol...
Adiponectin, an adipocyte-derived insulin-sensitizing and anti-inflammatory hormone, is suppressed in obesity through mechanisms involving chronic inflammation oxidative stress. Olive oil consumption associated with beneficial cardiometabolic actions, possible contributions from the antioxidant phenol hydroxytyrosol (HT) monounsaturated fatty acid oleic (OA, 18:1n-9 cis), both possessing vasculo-protective properties. We determined effects of HT OA, alone combination, on adiponectin...
Chronic inflammation of the adipose tissue (AT) is a major contributor to obesity-associated cardiometabolic complications. The olive oil polyphenol hydroxytyrosol (HT) contributes Mediterranean diet benefits through mechanisms still partially unknown. We investigated HT (1 and 10 μmol/L) effects on gene expression (mRNA microRNA) related induced by ng/mL tumor necrosis factor (TNF)-α in human Simpson–Golabi–Behmel Syndrome (SGBS) adipocytes. At real-time PCR, significantly inhibited...
Inflammatory bowel disease (IBD) implies the chronic inflammation of gastrointestinal tract, combined with systemic vascular manifestations. In IBD, incidence cardiovascular appears to be related an increase oxidative stress and endothelial dysfunction. Grape pomace contains high levels anti-oxidant polyphenols that are able counteract inflammatory symptoms. The aim this study was determine whether grape polyphenolic extract (GPE) mitigate overwhelming response in enterocyte-like cells...
Time spent outdoors and physical activity (PA) promote mental health. To confirm this relationship in the aftermath of COVID-19 lockdowns, we explored individual levels anxiety, depression, stress subjective well-being (SWB) a cohort academic students staff members tested their association with sport practice, PA at leisure time outdoors. Our cross-sectional study collected data during outbreak (April−May 2021) on 939 238 employees, who completed an online survey sociodemographic lifestyle...
Dietary long-chain fatty acids (FA) may influence pathological processes involving endothelial activation, including inflammation and atherosclerosis. We have previously shown that the n–3 FA docosahexaenoate (DHA) inhibits activation in range of nutritionally achievable plasma concentrations. The present study assessed structural determinants for this effect. Saturated, monounsaturated, n–6 polyunsaturated were incubated with cultured cells 24–72 h alone, then presence interleukin-1, tumor...
Mitochondria are fundamental organelles producing energy and reactive oxygen species (ROS); their impaired functions play a key role in endothelial dysfunction. Hydroxytyrosol (HT), well-known olive oil antioxidant, exerts health benefits against vascular diseases by improving function. However, the HT mitochondrial oxidative stress dysfunction is not clear yet. To investigate effects on ROS production inflamed endothelium, we used an vitro model of represented cultured cells, challenged...
Bone regeneration is a complex process regulated by several factors that control overlapping biological processes, coordinating interactions among distinct cell populations. There great interest in identifying new strategies for inducing osteogenesis safe and efficient manner. Concentrated Growth Factor (CGF) an autologous blood derived product obtained centrifugation of venous following the procedure set on Silfradent device. In this study effects CGF osteogenic differentiation human Marrow...