A5065999376- Genetic factors in colorectal cancer
- Extracellular vesicles in disease
- Genomic variations and chromosomal abnormalities
- Cancer Genomics and Diagnostics
- BRCA gene mutations in cancer
- Garlic and Onion Studies
- Growth Hormone and Insulin-like Growth Factors
- Metabolism, Diabetes, and Cancer
- Peroxisome Proliferator-Activated Receptors
- MicroRNA in disease regulation
- Pancreatic and Hepatic Oncology Research
- Chronic Lymphocytic Leukemia Research
- DNA Repair Mechanisms
- Colorectal Cancer Treatments and Studies
- Quinazolinone synthesis and applications
- CAR-T cell therapy research
- Neuroblastoma Research and Treatments
- Cancer, Lipids, and Metabolism
- Inflammatory Biomarkers in Disease Prognosis
- Pharmacological Effects of Natural Compounds
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Helminth infection and control
- Genomics and Chromatin Dynamics
- Pituitary Gland Disorders and Treatments
University of Chieti-Pescara
2016-2025
University Foundation
2007-2012
Genomics (United Kingdom)
2012
National Center for Complementary and Integrative Health
2003
National Institutes of Health
2003
The immune system seems to play a fundamental role in breast cancer responsiveness chemotherapy. We investigated two peripheral indicators of immunity/inflammation, i.e. neutrophil lymphocyte ratio (NLR) and platelet (PLR), order reveal possible relationship with pathological complete response (pCR) patients early or locally advanced treated neoadjuvant chemotherapy (NACT).We retrospectively analyzed 373 consecutive affected by candidates NACT. blood cell count before starting NACT was...
Abstract Inflammatory bowel disease (IBD) is a morbid condition characterized by relapsing–remitting inflammation of the colon, accompanied persistent gut dysmotility and abdominal pain. Different reports demonstrated biological activities aged black garlic (ABG), including anti‐inflammatory antioxidant effects. We aimed to investigate beneficial effects exerted ABGE on colon using ex vivo in experimental models. investigated an ABG water extract (ABGE) rat specimens exposed E. coli...
The spectrum of BRCA1/2 genetic variation in breast-ovarian cancer patients has been scarcely investigated outside Europe and North America, with few reports for South where Amerindian founder effects recent multiracial immigration are predicted to result high diversity. We describe here the results BRCA1/BRCA2 germline analysis an Argentinean series breast/ovarian selected young age at diagnosis or family history.The study (134 patients) included 37 cases diagnosed within 40 years no...
Pancreatic cancer (PC) is the fourth most common cause of death. Combination therapies with classical chemotherapeutic agents improved treatment advanced PC at cost a relevant toxicity, but 5-year survival rate remains below 5%. Consequently, new therapeutic options for this disease are urgently needed. In study, we explored effect two repurposed drug candidates nelfinavir and nitroxoline, approved non-anticancer human use, in cell lines. Nelfinavir nitroxoline were tested as single agents,...
Pancreatic cancer (PC) is one of the most lethal, chemoresistant malignancies and it paramount importance to find more effective therapeutic agents. Repurposing non-anticancer drugs may expand repertoire molecules. Studies on repurposing benzimidazole-based anthelmintics in PC their interaction with agents approved for therapy are lacking. We analyzed effects four Food Drug Administration (FDA)-approved benzimidazoles AsPC-1 Capan-2 pancreatic cell line viability. Notably, parbendazole was...
Colorectal cancer (CRC) is one of the most incident and lethal malignancies worldwide. Recent treatment advances prolonged survival in patients with metastatic colorectal (mCRC). However, there are still few biomarkers to guide clinical management selection mCRC. In this study, we applied an optimized flow cytometry protocol for EV identification, enumeration, subtyping blood samples 54 mCRC 48 age sex-matched healthy controls (HCs). The overall (OS) response rate (ORR) were evaluated...
Pancreatic cancer (PC) is one of the deadliest malignancies, with an increasing incidence and limited response to current therapeutic options. Therefore, more effective low-toxic agents are needed improve PC patients' outcomes. Resveratrol (RSV) a natural polyphenol multiple biological properties, including anticancer effects. In this study, we explored antiproliferative activities newly synthetized RSV analogues in panel cell lines evaluated physicochemical properties most active compound....
Immune checkpoint inhibitors (ICIs) induce durable clinical responses only in a subset of advanced non-small cell lung cancer (NSCLC) patients. There is need to identify mechanisms ICI resistance and immunotherapy biomarkers improve benefit. In this study, we evaluated the prognostic predictive value circulating endothelial leukocyte-derived extracellular vesicles (EV) patients with NSCLC treated anti-PD-1/PD-L1 agents. addition, relationship between total blood EV proteome response ICIs was...
Repurposing of approved non-antitumor drugs represents a promising and affordable strategy that may help to increase the repertoire effective anticancer drugs. Benzimidazole-based anthelmintics are antiparasitic commonly employed both in human veterinary medicine. Benzimidazole compounds being considered for drug repurposing due antitumor activities displayed by some members family. In this study, we explored effects large series benzimidazole-based (and enantiomerically pure forms those...
Inflammatory bowel diseases (IBDs) are chronic and multifactorial inflammatory conditions of the colonic mucosa (ulcerative colitis), characterized by increased unbalanced immune response to external stimuli. Garlic its bioactive constituents were reported exert various biological effects, including anti-inflammatory, antioxidant immunomodulatory activities. We aimed evaluate protective effects a hydroalcoholic (GHE) water (GWE) extract from Sicilian variety garlic, known as Nubia red on an...
Multiple studies demonstrated biological activities of aged black garlic, including anti-inflammatory, antioxidant, and cardioprotective effects. We aimed to investigate the protective effects an garlic water extract (ABGE) alone or in association with multivitamins consisting combined Vitamins D, C, B12, on mouse heart specimens exposed E. coli lipopolysaccharide (LPS). Moreover, we studied hydrogen sulphide (H2S) releasing properties membrane hyperpolarization effect Formulation composed...
Chimeric Antigen Receptor (CAR) T cell-derived Extracellular Vesicles (EVs) might represent a new therapeutic tool for boosting CAR-T cell antileukemic effects. Here, cohort of 22 patients infused with CD19.CAR-T cells was monitored the presence circulating CD19.CAR+-T EVs (CD19.CAR+EVs), which were then separated and functionally characterized their killing abilities. A GMP-compliant separation method also developed. Results demonstrated that CD19.CAR+EVs detectable in peripheral blood up...
Abstract Paragangliomas (PGLs) are infiltrating autonomic nervous system tumors that cause important morbidity. At present, surgery is the only effective therapeutic option for this rare tumor. Thus, new agents PGL treatment should be identified. Using unique cell models established in our laboratory, we evaluated effect of dichloroacetate (DCA) as single agent or a novel combination with other metabolic drugs, including GW6471 and metformin. DCA metformin had not been tested before PGL....
Grape (Vitis vinifera L.) pomace is a residue derived from the winemaking process, which contains bioactive compounds displaying noteworthy health-promoting properties. The aim of present study was to investigate phenolic composition and protective effects water extract grape (WEGP) in colorectal cancer cell line SW480 isolated mouse colon exposed Escherichia coli lipopolysaccharide (LPS). decreased SW-480 viability, as well vascular endothelial factor A (VEGFA), hypoxia-induced 1α (HIF1α),...
The aim of the present study was to investigate possible protective effects a garlic hydroalcoholic extract on burden oxidative stress and inflammation occurring mouse heart specimens exposed E. coli lipopolysaccharide (LPS), which is well-established inflammatory stimulus. Headspace solid-phase microextraction combined with gas chromatography–mass spectrometry (HS-SPME/GC–MS) technique applied determine volatile fraction powder, HS-SPME conditions were optimized for each most representative...
Naturally occurring mutations in insulin receptor substrate-1 (IRS-1) have previously been implicated impaired action. We now report a novel mutation IRS-1 with substitution of Arg for Thr608 that was identified patient type 2 diabetes mellitus. detected the T608R 1 136 chromosomes from diabetic patients and 0 120 nondiabetic controls, suggesting this is rare variant. Conservation human, monkey, rat, mouse, chicken sequences consistent crucial function residue. Moreover, located near YMXM...