A5073062718- Nuclear Physics and Applications
- Radioactivity and Radon Measurements
- Radioactive element chemistry and processing
- Heavy metals in environment
- Genomics, phytochemicals, and oxidative stress
- Tendon Structure and Treatment
- Oral microbiology and periodontitis research
- Nitric Oxide and Endothelin Effects
- Bone Tissue Engineering Materials
- Analytical chemistry methods development
- Lichen and fungal ecology
- Radiopharmaceutical Chemistry and Applications
- Geochemistry and Geologic Mapping
- Mercury impact and mitigation studies
- Parkinson's Disease Mechanisms and Treatments
- Heme Oxygenase-1 and Carbon Monoxide
- Bone and Dental Protein Studies
- Synthesis and biological activity
- Air Quality and Health Impacts
- Endodontics and Root Canal Treatments
- Electrochemical Analysis and Applications
- Hemoglobin structure and function
- Sports injuries and prevention
- Eicosanoids and Hypertension Pharmacology
- Shoulder Injury and Treatment
University of Chieti-Pescara
2016-2025
University Hospital Regensburg
2015-2022
University of Regensburg
2015-2022
Istituto Nazionale di Ricerca Metrologica
2008
University of Pavia
1991-2005
Istituto Nazionale di Fisica Nucleare, Laboratori Acceleratori e Superconduttività Applicata
1995-2001
Istituto Nazionale di Fisica Nucleare, Sezione di Pavia
1990-1999
Istituto di Genetica Molecolare
1995
University of Milan
1995
National Institute of Standards and Technology
1978
Abstract In recent years, there has been a considerable increasing interest in the use of greater wax moth Galleria mellonella as an animal model. vivo pharmacological tests, concerning efficacy and toxicity novel compounds are typically performed mammalian models. However, latter is costly, laborious requires ethical approval. this context, G. larvae can be considered valid option due to their ease absence rules. Furthermore, it demonstrated that immune system these invertebrates similarity...
Tissue engineering is widely recognized as a promising approach for bone repair and reconstruction. Several attempts have been made to achieve materials that must be compatible, osteoconductive, osteointegrative mechanical strength provide structural support. Composite scaffolds consisting in biodegradable natural polymers are very constructs. Hydroxyapatite (HAp) can support alginate inorganic reinforcement osteoconductive component of alginate/HAp composite scaffolds. Therefore,...
Mesenchymal stromal/stem cells (MSCs) are increasingly employed for tissue regeneration, largely mediated through paracrine actions. Currently, extracellular vesicles (EVs) released by MSCs major mediators of these effects. We evaluated whether rat-bone-marrow-MSC-derived EVs (rBMSCs-EVs) can ameliorate tendon injury in an vivo rat model. Pro-collagen1A2 and MMP14 protein expressed rBMSC-EVs, important factors extracellular-matrix tendon-remodeling. In addition, we found pro-collagen1A2...
Snail slime (SS) is a viscous secretion obtained from different snail species. SS composition variable according to factors such as the extraction method. Even if several papers have been published regarding this topic, molecular mechanisms at base of biological effects remain unexplored. Thus, aim study evaluate capability SS, extracted with cruelty-free Muller method, promote viability and angiogenesis processes and, in parallel, counteract inflammation occurrence on skin cell populations....
Two different produced and packaged commercial typologies of pomegranate juice were analyzed for their physicochemical, nutritional, biological properties. The effects classical pasteurization (PJ) high-pressure processing (HP), applied during the productive cycle, evaluated through several advanced analytical methods, such as CIEL*a*b* colorimetry, HPLC-DAD, DI-ESI-MS MS/MS, NMR analyses. Moreover, exerted activity two juices was monitored Total Phenolic Flavonoid Contents, antiradical,...
Tendinopathy is often described as a complex and multifactorial condition which affects tendons. Tendon disorders are marked by reduction in mechanical function, accompanied pain swelling. At the molecular level, tendinopathy leads to oxidative stress-driven inflammation, increased cell death, disruption of extracellular matrix balance, abnormal growth capillaries arteries, degeneration collagen formation. Here, we report an innovative approach modulate stress during based on...
The vascular system is primarily responsible for orchestrating the underlying healing processes to achieve tissue regeneration, thus promotion of angiogenic events could be a useful strategy repair injured tissues. Among several approaches stimulate non-invasive devices are currently widely diffused. Complex Magnetic Fields (CMFs) innovative pulsed multifrequency electromagnetic fields used their promising results in clinical applications, such as diabetic foot treatment or edema resorption....
Background—Aggressive solid tumors are commonly characterized by both basic intracellular pH and acidic extracellular pH, which increase cell survival proliferation. As carbonic anhydrases IX/XII involved in this regulation, their inhibition is an appealing approach cancer therapy, avoiding Substituted coumarins selective non-classical CA IX XII inhibitors. Methods—In study, new 7-hydroxycoumarinamides were synthesized assayed for antiproliferative activity. Results—All of the coumarinamides...
Embryonic development is a complex process of concurrent events comprising cell proliferation, differentiation, morphogenesis, migration, and tissue remodeling. To cope with the demands arising from these developmental processes, cells increase their nutrient uptake, which subsequently increases metabolic activity. Mitochondria play key role in maintenance metabolism production reactive oxygen species (ROS) as natural byproduct. Regulation ROS by antioxidants critical tightly regulated...