A5061176144- Enzyme function and inhibition
- Bacterial Infections and Vaccines
- Synthesis and Catalytic Reactions
- Oral microbiology and periodontitis research
- Phenothiazines and Benzothiazines Synthesis and Activities
- Helicobacter pylori-related gastroenterology studies
- Bacterial biofilms and quorum sensing
- Antimicrobial Peptides and Activities
- HIV/AIDS oral health manifestations
- Infectious Encephalopathies and Encephalitis
- Quinazolinone synthesis and applications
- Biochemical and Structural Characterization
- Powdery Mildew Fungal Diseases
- Probiotics and Fermented Foods
- Gut microbiota and health
- Garlic and Onion Studies
- Aquaculture disease management and microbiota
- Extracellular vesicles in disease
- Dental Radiography and Imaging
- Nanoplatforms for cancer theranostics
- Inflammatory mediators and NSAID effects
- Legionella and Acanthamoeba research
- Pneumonia and Respiratory Infections
- Invertebrate Immune Response Mechanisms
- Periodontal Regeneration and Treatments
University of Chieti-Pescara
2022-2024
The enormous burden of the COVID-19 pandemic in economic and healthcare terms has cast a shadow on serious threat antimicrobial resistance, increasing inappropriate use antibiotics shifting focus drug discovery programmes from antibacterial antifungal fields. Thus, there is pressing need for new antimicrobials involving innovative modes action (MoAs) to avoid cross-resistance rise. Thiosemicarbazones (TSCs) stand out due their easy preparation polypharmacological application, also infectious...
Abstract In recent years, there has been a considerable increasing interest in the use of greater wax moth Galleria mellonella as an animal model. vivo pharmacological tests, concerning efficacy and toxicity novel compounds are typically performed mammalian models. However, latter is costly, laborious requires ethical approval. this context, G. larvae can be considered valid option due to their ease absence rules. Furthermore, it demonstrated that immune system these invertebrates similarity...
The World Health Organization has indicated Helicobacter pylori as a high-priority pathogen whose infections urgently require an update of the antibacterial treatments pipeline. Recently, bacterial ureases and carbonic anhydrases (CAs) were found to represent valuable pharmacological targets inhibit growth. Hence, we explored underexploited possibility developing multiple-targeted anti-H. therapy by assessing antimicrobial antibiofilm activities CA inhibitor, carvacrol (CAR), amoxicillin...
The microbial biofilm has been defined as a "key virulence factor" for multitude of microorganisms associated with chronic infections. Its multifactorial nature and variability, well an increase in antimicrobial resistance, suggest the need to identify new compounds alternatives commonly used antimicrobials. aim this study was assess antibiofilm activity cell-free supernatant (CFS) its sub-fractions (SurE 10 K molecular weight <10 kDa SurE <30 kDa), produced by Limosilactobacillus reuteri...
Introduction Bacterial Membrane Vesicles (MVs) play important roles in cell-to-cell communication and transport of several molecules. Such structures are essential components Extracellular Polymeric Substances (EPS) biofilm matrix many bacterial species displaying a structural function role virulence pathogenesis.
Abstract The aim of this study was to evaluate the antimicrobial efficacy an air gas soft jet CAP for its potential use in removing oral biofilms, given that plasma-based technologies have emerged as promising methods periodontology. Two types biofilms were developed, one by Streptococcus mutans UA 159 bacterial strain and other a complex mixture saliva microorganisms isolated from patient with periodontitis. This latter biofilm characterized via Next Generation Sequencing determine main...
Ciprofloxacin (CPX) is one of the most employed antibiotics in clinics to date. However, rise drug-resistant bacteria dramatically impairing its efficacy, especially against life-threatening pathogens, such as
'Sulmona red garlic' is an Italian variety characterized by a tunica surrounding white bulb. Red tunicae and non-commercial small bulbs are food wastes that must be studied for their added value. Hydroalcoholic extracts, obtained separated inner outer peeled of commercial bulbs, harvested at two different years, were first with respect to color, polyphenolic content, antiradical activity. Then, untargeted metabolic profile means electrospray ionization Fourier transform ion cyclotron...
Research into novel anti-
<title>Abstract</title> The aim of this study was to evaluate the antimicrobial efficacy an air gas soft jet CAP for its potential use in removing oral biofilms, given that plasma-based technologies have emerged as promising methods periodontology. Two types biofilms were developed, one by<italic>Streptococcus mutans</italic>UA 159 bacterial strain and other by a complex mixture saliva microorganisms isolated from patient with periodontitis. This latter biofilm characterized via Next...
The World Health Organization defines probiotics as “live microorganisms which, when administered in adequate amounts, confer a health benefit on the host”. One of most well studied is Limosilactobacillus reuteri, Gram-positive, rod-shaped bacterium that colonizes mucosal surfaces mammals and birds considered autochthonous to human microbiome. Genetic analyses have confirmed this microorganism has co-evolved with its host, prerequisite for development mutualistic relation. On one hand, L....
Gastric cancer (GC) is the fifth most frequently diagnosed and third leading cause of death worldwide. Helicobacter pylori (Hp) infection an important risk factor for GC. However, etiology tumor multifactorial, since only 1-3% infected patients develop cancer. Therefore, attention should be focused on role microbiota in gastric tumorigenesis some studies alteration GC has been shown. Fusobacterium nucleatum (Fn) found biopsies with its not clearly established, this study investigated effects...