A5064853793- Antimicrobial Resistance in Staphylococcus
- Bacterial biofilms and quorum sensing
- Bacterial Identification and Susceptibility Testing
- Antibiotic Resistance in Bacteria
- Infective Endocarditis Diagnosis and Management
- Streptococcal Infections and Treatments
- Antifungal resistance and susceptibility
- Plant Pathogenic Bacteria Studies
- Orthopedic Infections and Treatments
- Mycobacterium research and diagnosis
- Microbial Metabolism and Applications
- Pneumonia and Respiratory Infections
- Marine Toxins and Detection Methods
- Antibiotics Pharmacokinetics and Efficacy
- Immunotherapy and Immune Responses
- Agricultural Practices and Plant Genetics
- Bacterial Infections and Vaccines
- Antimicrobial Peptides and Activities
- Biochemical and Structural Characterization
- Antimicrobial agents and applications
- Pharmaceutical and Antibiotic Environmental Impacts
- Potato Plant Research
- RNA and protein synthesis mechanisms
- Immune Response and Inflammation
- Plant Virus Research Studies
University of Catania
2016-2025
Policlinico San Matteo Fondazione
2008
Azienda Ospedaliero Universitaria Ospedali Riuniti
2008
Sapienza University of Rome
2008
Policlinico Umberto I
2007
Universidade Nova de Lisboa
2004
University of Perugia
1974-2000
Institute of Pharmacology
1980-1985
Abstract The aim of our study was to trace the dynamic changes hospital-associated methicillin-resistant Staphylococcus aureus (HA-MRSA) lineages in Italy, comparing genotypic backgrounds contemporary isolates over a period 17 years, with those sample early MRSA strains from 1980. In total, 301 non-repetitive clinical isolates, recovered 19 Italian hospitals between 1990 and 2007 were selected analyzed for their antibiotic resistance, typed by PFGE SCC mec , grouped into clonal-types further...
Glycopeptides are still the gold standard to treat MRSA (Methicillin Resistant Staphylococcus aureus) infections, but their widespread use has led vancomycin-reduced susceptibility [heterogeneous Vancomycin-Intermediate-Staphylococcus aureus (hVISA) and (VISA)], in which different genetic loci (regulatory, autolytic, cell-wall turnover cell-envelope positive charge genes) involved. In addition, reduced vancomycin can influence development of resistance daptomycin. Although phenotypic...
The release of antibiotics (AB) into the environment poses several threats for human health due to potential development AB-resistant natural bacteria. Even though use low-dose has been promoted in care and farming, significant amounts AB are observed aquatic environments. Knowledge on impact bacterial communities is missing both terms spread evolution resistance mechanisms, modifications community composition productivity. New approaches required study response microbial rather than...
Introduction Bacterial Membrane Vesicles (MVs) play important roles in cell-to-cell communication and transport of several molecules. Such structures are essential components Extracellular Polymeric Substances (EPS) biofilm matrix many bacterial species displaying a structural function role virulence pathogenesis.
Enterococcus faecalis is responsible for numerous serious infections, and treatment options often include ampicillin combined with an aminoglycoside or dual beta-lactam therapy a third-generation cephalosporin. The mechanism of relies on the saturation penicillin-binding proteins (PBPs). Ceftobiprole exhibits high affinity binding to nearly all E. PBPs, thus suggesting its potential utility in severe infections. availability therapeutic drug monitoring (TDM) ceftobiprole has prompted use...
The macrolide efflux gene mef(A) of the Streptococcus pyogenes clinical strain 2812A was found to be carried by a 52-kb chromosomal genetic element that could transferred conjugation chromosome other streptococcal species. characteristics this are typical conjugative transposons and named Tn1207.3. size Tn1207.3 established pulsed-field gel electrophoresis (PFGE), DNA sequencing analysis showed 7,244 bp at left end were identical those pneumococcal Tn1207.1 element. Tn1207.3-like elements...
Abstract We assessed the clinical relevance and performed molecular characterization of 36 multidrug-resistant strains Corynebacterium striatum. Pulsed-field gel electrophoresis confirmed a single clone, possessing erm(X), tetA/B, cmxA/B, aphA1 genes, but few related subclones. This strain is emerging as pathogen in Italy.
Despite 10 years of clinical use, linezolid resistance in Staphylococcus aureus and coagulase-negative staphylococci (CoNS) is still a rare phenomenon. This study reports the mechanisms strain types seen clusters linezolid-resistant CoNS from two different hospitals Italy during period 2008-09.Genes associated with were subjected to molecular analysis isolates characterized by PFGE macrorestriction using SmaI.Thirty-three methicillin-resistant comprising epidermidis (24), hominis (5)...
Bloodstream infections due to Staphylococcus aureus (BSI) are serious both in hospitals and the community, possibly leading infective endocarditis (IE). The use of glycopeptides has been recently challenged by various forms low-level resistance. This study evaluated distribution MSSA MRSA isolates from BSI IE 4 Italian hospitals, their antibiotic susceptibility--focusing on emergence hVISA--and genotypic relationships. Our results demonstrate that epidemiology is changing versus different...
Penicillin-resistance among
Enterococcus faecalis is responsible for a large variety of severe infections. This study case series reporting our experience in the treatment E. invasive infections with ampicillin combination ceftobiprole (ABPR).We retrospectively analyzed all medical records patients admitted to University Hospital Udine from January December 2020 diagnosis infective endocarditis or primary non-primary complicated uncomplicated bacteremia caused by faecalis.Twenty-one were included final analysis. The...
Here we report for the first time, a detailed characterization of variant SCCmec element, in methicillin-resistant Staphylococcus intermedius human isolate. S. is coagulase-positive zoonotic microrganism, recently classified as separate species. In routine clinical laboratory practice, coagulase production used criterion pathogenicity related to aureus, but frequently misidentified—being mistaken aureus—and consequently its real incidence underestimated. have been found only occasionally...
ABSTRACT We describe here the isolation of 8 beta-lactamase-producing multidrug-resistant Enterococcus faecium isolates in 2010. All strains showed diverse pulsed-field gel electrophoresis (PFGE) profiles, all belonging to same clonal complex, CC17. By PCR and hybridization experiments, entire blaZ-blaI-blaR1 operon was found. The beta-lactamase activity demonstrated at a high inoculum presence methicillin after overnight incubation.
A unique case of community acquired methicillin resistant Staphylococcus aureus (MRSA) sepsis, with endocardial and cerebral metastatic seeding, caused by a strain representative the Italian clone, is described. The patient was 47-y-old man without apparent risk factors for endocarditis MRSA infection who developed coma multiple cerebritis lesions under vancomycin plus amikacin therapy. He eventually cured addition linezolid to initial antimicrobial regimen. This observation seems confirm...