A5082741208- Chronic Obstructive Pulmonary Disease (COPD) Research
- Liver Disease Diagnosis and Treatment
- Pulmonary Hypertension Research and Treatments
- Liver physiology and pathology
- Neonatal Respiratory Health Research
- Eicosanoids and Hypertension Pharmacology
- Liver Disease and Transplantation
- Genetic and Kidney Cyst Diseases
- Mindfulness and Compassion Interventions
- Pleural and Pulmonary Diseases
- Protease and Inhibitor Mechanisms
- Genomics, phytochemicals, and oxidative stress
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Congenital Diaphragmatic Hernia Studies
- Peptidase Inhibition and Analysis
- Connective tissue disorders research
- Pharmacological Effects of Natural Compounds
- Antioxidant Activity and Oxidative Stress
- Cystic Fibrosis Research Advances
- Rheumatoid Arthritis Research and Therapies
- Tracheal and airway disorders
- Respiratory Support and Mechanisms
- Asthma and respiratory diseases
- Calpain Protease Function and Regulation
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
University of Siena
2008-2021
Institute of Food Science
2015
National Research Council
2015
Cystic Fibrosis Research Foundation
1988
Merck & Co., Inc., Rahway, NJ, USA (United States)
1986
Scavenger Receptor B1 (SR-B1), also known as HDL receptor, is involved in cellular cholesterol uptake. Stratum corneum (SC), the outermost layer of skin, composed more than 25% cholesterol. Several reports support view that alteration SC lipid composition may be cause impaired barrier function which gives rise to several skin diseases. For this reason regulation genes uptake extreme significance for health. Being first shield against external insults, exposed noxious substances and among...
Several cross-sectional studies have documented neuroanatomical changes in individuals with a long history of meditation, while few evidences are available about the interaction between and psychological even during brief exposure to meditation. Here we analyzed several morphometric indexes at both cortical subcortical brain level, as well multiple dimensions, before after -8 weeks- Mindfulness Based Stress Reduction (MBSR) training program, group 23 meditation naïve-subjects compared...
A girl presented in the neonatal period with hydrocephalus, bronchiectasis, and ciliary aplasia. common defect both respiratory tract cilia ventricular ependyma may explain association of two diseases.
The tight-skin (tsk) mouse has been recently proposed as a model of genetically determined emphysema. In the present study, development this lung lesion was investigated morphometrically in both male and female tsk mice from 4 days to 16 months age. "Pallid" (pa) with closely related genetic background served controls. Despite small differences mean linear intercept seen at 1 months, were found be similarly susceptible emphysematous lesion. Three main phases observed evolution first phase, 2...
In order to evaluate the clinical value of saccharin test as a practical and simple measure mucociliary clearance, nasal clearance (NMCC) ciliary ultrastructure were studied in 22 patients suspected having primary dyskinesia (PCD) based on test. Ten fulfilling diagnostic criteria PCD had pathological response (transport time greater than 60 minutes), this was consistently associated with ultrastructural defects, specific for PCD. These results validate suitability use screening procedure...
Cigarette smoke (CS) is a main risk factor in chronic obstructive pulmonary disease (COPD), but only 20% of smokers develop COPD, suggesting genetic predisposition. Animal studies have shown that C57BL/6J mice are sensitive to CS and emphysema, whereas Institute Cancer Research (ICR) not. To investigate the potential factors responsible for different susceptibility ICR CS, we evaluated alveolar macrophages (AMs) isolated from these strains possible mechanisms involved inflammatory oxidative...
Mindfulness is a meditation practice frequently associated with changes in subjective evaluation of cognitive and sensorial experience, as well modifications brain activity morphometry. Aside from the anatomical localization functional induced by mindfulness practice, little known about effective magnetic resonance imaging (fMRI) connectivity. Here we performed connectivity fMRI analysis group healthy individuals participating an 8-week mindfulness-based stress reduction (MBSR) training...
Oxidative stress (OS) is important in the pathogenesis of autoimmune diseases such as rheumatoid arthritis (RA) and its experimental model – adjuvant (AA). Antioxidants are scarcely studied autoimmunity, future analyses needed to assess effects ameliorating these diseases. Although there studies about antioxidants on course RA, their role combination therapy has not yet been detail, especially extra-articular manifestations AA. During 28-d administration pinosylvin (PIN) monotherapy with...
In this paper we report the serum antiprotease screening and biochemical functional characteristics of neutrophils in a variety mouse strains with different susceptibilities for developing protease-mediated injury. C57Bl/6J mice their mutants tight-skin pallid have lower elastase inhibitory capacity (-30, -65 -70% respectively) than other inbred (i.e. NMRI Balb/c, which both similar values). We demonstrate that these values are consequence decreased concentration alpha 1-protease inhibitor...
Abstract One hundred fifty‐four children with recurrent or chronic infections of the lower respiratory tract compatible diagnosis primary ciliary dyskinesia (PCD) were evaluated for presence ultrastructural abnormalities. Studies performed on multiple samples mucosa obtained by nasal and bronchial brushing. Twenty‐eight showed defects PCD: Twenty‐four presented dynein arm deficiency (either as isolated defect in association microtubular abnormalities), two had aplasia, Eleven patients PCD...