A5024350349- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Tryptophan and brain disorders
- Neurotransmitter Receptor Influence on Behavior
- Neurogenesis and neuroplasticity mechanisms
- Analytical Methods in Pharmaceuticals
- Neuroscience and Neuropharmacology Research
- Nuclear Receptors and Signaling
- Drug Transport and Resistance Mechanisms
- Antibiotics Pharmacokinetics and Efficacy
- Evolutionary Psychology and Human Behavior
- Wildlife Ecology and Conservation
- COVID-19 Clinical Research Studies
- MicroRNA in disease regulation
- Pharmacological Effects and Toxicity Studies
- Treatment of Major Depression
- Dental Health and Care Utilization
- Animal Behavior and Reproduction
- Breastfeeding Practices and Influences
- Biochemical effects in animals
- Respiratory and Cough-Related Research
- Pharmacogenetics and Drug Metabolism
- Molecular Biology Techniques and Applications
- Bacterial Identification and Susceptibility Testing
- Infant Health and Development
Rutgers, The State University of New Jersey
2017-2025
Saint Joseph's University
2017-2021
Rutgers Sexual and Reproductive Health and Rights
2018
Given the obesity epidemic and prevalence of comorbidities, there is an ongoing need to understand health consequences this disease state better. Understanding gene expression signals will facilitate identification mechanisms kidney liver dysfunction/disease often present in individuals with obesity. qPCR standard method for studying changes relative expression. Reference genes (RGs) are obligatory accurately normalizing mRNA transcript levels across samples. Despite qPCR, reliability data...
Abstract Early-life stress (ELS) leads to stress-related psychopathology in adulthood. Although dysfunction of corticotropin-releasing hormone (CRH) signaling the bed nucleus stria terminalis (BNST) mediates chronic stress-induced maladaptive affective behaviors that are historically associated with mood disorders such as anxiety and depression, it remains unknown whether ELS affects CRH function adult BNST. Here we applied a well-established paradigm (24 h maternal separation (MS) at...
To investigate how obesity affects the pharmacokinetics of biologics in a rat model. Male Long-Evans rats were fed high-fat diet from age 3 weeks and development was monitored by measuring body size composition (fat lean mass). The animals received nivolumab (1 8 mg/kg) or recombinant human erythropoietin (rHuEPO, 1000 IU/kg) intravenous subcutaneous injection. Serum samples collected analyzed using an enzyme-linked immunosorbent assay (ELISA). Endogenous IgG also measured study. A standard...
Abstract The prevalence of obesity is rapidly increasing worldwide, however there a notable gap in understanding how affects the pharmacokinetics drugs and dosing should be adjusted obese population. goals this work were to evaluate plasma tissue disposition piperacillin, cefazolin, cefoxitin rat model diet-induced compared lean cohort. Male Long-Evans rats fed high-fat or control diets for 23 weeks. Various measures body size composition collected. animals administered mixture containing 50...
Abstract Antidepressants that target monoaminergic systems, such as selective serotonin reuptake inhibitors (SSRIs), are widely used to treat neuropsychiatric disorders including major depressive disorder, several anxiety disorders, and obsessive-compulsive disorder. However, these treatments not ideal because only a subset of patients achieve remission. The reasons why some individuals remit antidepressant while others do unknown. Here, we developed paradigm assess treatment resistance in...
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection and the resulting Coronavirus disease 2019 emerged in late is responsible for significant morbidity mortality worldwide. A hallmark of severe COVID‐19 exaggerated systemic inflammation, regarded as a “cytokine storm,” which contributes to damage various organs, primarily lungs. The inflammation associated with some viral illnesses known alter expression drug‐metabolizing enzymes transporters. These alterations...
Mood disorders, including major depressive disorder, can be precipitated by chronic stress. The Y-maze barrier task is an effort-related choice test that measures motivation to expend effort and obtain reward. In mice, stress exposure significantly impacts work for a higher value reward when lesser freely available compared unstressed mice. Here we describe the corticosterone administration paradigm, which produces shift in effortful responding task. task, one arm contains 4 food pellets,...
Abstract Background Pathophysiological changes associated with obesity might impact various drug pharmacokinetics (PK) parameters. The liver and kidneys are the primary organs involved in clearance, function of hepatic renal transporters is critical to efficient elimination (or reabsorption). Considering an increased BMI on drug’s PK crucial directing dosing decisions. Given role biodisposition, this study investigated how overweight affect gene expression transporters. Methods Human kidney...
Natural variations in parenting are associated with differences expression of several hormones and neuropeptides which may mediate lasting effects on offspring development, like regulation stress reactivity social behavior. Using the bi-parental California mouse, we have demonstrated that aggression programmed, at least part, by paternal behavior as adult model degree parental received development more territorial following high compared to low levels care. Development these behaviors be...
Depression is a complex psychiatric disorder that major burden on society, with only ~33% of depressed patients attaining remission upon initial monotherapy selective serotonin reuptake inhibitor (SSRI). In preclinical studies using rodents, chronic stress paradigms, such as corticosterone and social instability stress, are used to induce avoidance behaviors associated negative affective states. Chronic fluoxetine (FLX; an SSRI) treatment reverses these stress-induced behavioral changes in...
Abstract Some mood disorders, such as major depressive disorder, are more prevalent in women than men. However, historically preclinical studies rodents have a lower inclusion rate of females males, possibly due to the fact that behavior can be affected by estrous cycle. Several demonstrated chronic antidepressant treatment decrease anxiety-like behaviors and increase adult hippocampal neurogenesis male rodents. very few conclusively looked at effects antidepressants on across cycle...
Mood disorders, including major depressive disorder, can be precipitated by chronic stress. The Y-maze barrier task is an effort-related choice test that measures motivation to expend effort and obtain reward. In mice, stress exposure significantly impacts work for a higher value reward when lesser freely available compared unstressed mice. Here we describe the corticosterone administration paradigm, which produces shift in effortful responding task. task, one arm contains 4 food pellets,...
Antidepressants that target monoaminergic systems, such as selective serotonin reuptake inhibitors (SSRIs), are widely used to treat neuropsychiatric disorders including major depressive disorder, several different anxiety disorders, and obsessive-compulsive disorder. However, these treatments not ideal because only a subset of patients achieve remission. The reasons why some individuals remit antidepressant while others do unknown. Here, we developed paradigm assess treatment resistance in...
ABSTRACT Despite stress-associated disorders having a higher incidence rate in females, preclinical research mainly focuses on males. Chronic stress paradigms, such as chronic social defeat and corticosterone administration, were designed validated males subsequent attempts to use these paradigms females has demonstrated sex differences the behavioral HPA axis response stress. Here, we developed paradigm, instability (SIS), which exposes adult mice unstable hierarchies for 7 weeks. SIS...