Sadia Abbasi
A5008666126- COVID-19 Clinical Research Studies
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Pneumonia and Respiratory Infections
- COVID-19 and healthcare impacts
- Intensive Care Unit Cognitive Disorders
- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- interferon and immune responses
- Galectins and Cancer Biology
- Family and Patient Care in Intensive Care Units
- Coronary Artery Anomalies
- Nosocomial Infections in ICU
- Nigella sativa pharmacological applications
- Peptidase Inhibition and Analysis
- Neurological Complications and Syndromes
- Digital Imaging for Blood Diseases
- Healthcare Decision-Making and Restraints
- Moyamoya disease diagnosis and treatment
- Menstrual Health and Disorders
- Heparin-Induced Thrombocytopenia and Thrombosis
- Primary Care and Health Outcomes
- Adenosine and Purinergic Signaling
Stony Brook University Hospital
2019-2023
Stony Brook School
2020-2022
Stony Brook University
2020-2022
MemorialCare Health System
2022
Liaquat University of Medical & Health Sciences
2019-2020
National Institute of Allergy and Infectious Diseases
2007-2019
National Institutes of Health
2009-2019
Isra University
2015
BackgroundMany patients with COVID-19 have been treated plasma containing anti-SARS-CoV-2 antibodies. We aimed to evaluate the safety and efficacy of convalescent therapy in admitted hospital COVID-19.MethodsThis randomised, controlled, open-label, platform trial (Randomised Evaluation Therapy [RECOVERY]) is assessing several possible treatments hospitalised UK. The underway at 177 NHS hospitals from across Eligible consenting were randomly assigned (1:1) receive either usual care alone...
BackgroundAspirin has been proposed as a treatment for COVID-19 on the basis of its anti-thrombotic properties. We aimed to evaluate efficacy and safety aspirin in patients admitted hospital with COVID-19.MethodsIn this randomised, controlled, open-label, platform trial, several possible treatments were compared usual care hospitalised COVID-19. The trial took place at 177 hospitals UK, two Indonesia, Nepal. Eligible consenting adults randomly allocated 1:1 ratio either standard plus 150 mg...
BackgroundLow-dose corticosteroids have been shown to reduce mortality for patients with COVID-19 requiring oxygen or ventilatory support (non-invasive mechanical ventilation, invasive extracorporeal membrane oxygenation). We evaluated the use of a higher dose in this patient group.MethodsThis randomised, controlled, open-label platform trial (Randomised Evaluation Therapy [RECOVERY]) is assessing multiple possible treatments hospitalised COVID-19. Eligible and consenting adult clinical...
The IRF and Ets families of transcription factors regulate the expression a range genes involved in immune cell development function. However, understanding molecular mechanisms each family member has been limited due to their redundancy broad effects on multiple lineages cells. Here, we report that double deletion floxed Irf8 Spi1 (encoding PU.1) by Mb1-Cre (designated DKO mice) B lineage resulted severe defects follicular germinal center (GC) Class-switch recombination antibody affinity...
BackgroundEmpagliflozin has been proposed as a treatment for COVID-19 on the basis of its anti-inflammatory, metabolic, and haemodynamic effects. The RECOVERY trial aimed to assess safety efficacy in patients admitted hospital with COVID-19.MethodsIn randomised, controlled, open-label trial, several possible treatments are compared usual care hospitalised COVID-19. In this analysis, we eligible consenting adults who were randomly allocated 1:1 ratio either standard alone or plus oral...
IFN regulatory factor 8 (IRF8) is a transcription that affects the differentiation and function of myeloid, dendritic, B cells. Herein we report IRF8 regulates expression Mdm2, suppressor p53-dependent -independent apoptosis pathways, in germinal center (GC) In GC cells IRF8-deficient mice, Mdm2 transcripts were greatly down-regulated, MDM2 protein was poorly expressed Irf8(-/-) mice. Small interfering RNA-induced repression GC-derived cell line resulted decreased at level but increased p53...
Innate-like B-1a cells contribute significantly to circulating natural antibodies and mucosal immunity as well immunoregulation. Here we show that these classic functions of segregate between two unique subsets defined by expression plasma cell alloantigen 1 (PC1), also known ectonucleotide pyrophosphatase phosphodiesterase (ENPP1). These subsets, designated B-1a.PC1 lo hi , differ in IgH chain utilization. Adoptively transferred PC1 secreted more IgM intestinal IgA than cells. In contrast,...
Survival of antibody-secreting plasma cells (PCs) is vital for sustained antibody production. However, it remains poorly understood how long-lived PCs (LLPCs) are generated and maintained. Here we report that ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) preferentially upregulated in bone marrow LLPCs compared with their splenic short-lived counterparts (SLPCs). We studied ENPP1-deficient mice (Enpp1 -/- ) to determine the enzyme affects PC biology. Although Enpp1 normal levels...
Abstract IFN regulatory factor 8 (IRF8) is expressed in many types of blood cells and plays critical roles cellular differentiation function. However, the role IRF8 nonhematopoietic systems remains poorly understood. In this study, we provide evidence that a transcriptional modulator gastric mucosa necessary for limiting Helicobacter pylori colonization. H. infection significantly upregulated expression IRF8, which, turn, promoted IFN-γ by epithelial cells. Mice deficient exhibited increased...
Abstract Background The global coronavirus disease 2019 (COVID-19) pandemic offers the opportunity to assess how hospitals manage care of hospitalized patients with varying demographics and clinical presentations. goal this study was demonstrate impact densely populated residential areas on hospitalization identify predictors length stay mortality in COVID-19 one hardest hit counties internationally. Methods This a single-center cohort 1325 sequentially New York between March 2, 2020, May...
Plasma cell alloantigen 1 (PC1), also known as ENPP1 (ectonucleotide pyrophosphatase/phosphodiesterase 1), is an enzyme involved primarily in hydrolysis of adenosine triphosphate at the surface. Although expression pattern PC1 relatively broad, its B cells found significant levels only terminally differentiated germinal center cells, plasma and a subset B-1a mice. Here we describe studies designed to determine whether might define novel populations human with similarities mouse cells. We...
The ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) has documented roles in mineralization, nucleotide recycling, and insulin resistance. While ENPP1 was first identified as an alloantigen on mouse plasma cells (PCs), later studies revealed expression many tissues. Previously described monoclonal antibodies against expressed at the cell surface recognized only from mice bearing a allotype, ENPP1a, precluding of alternative allele, ENPP1b. Here, we characterize novel anti-ENPP1...
BACKGROUND: Premenstrual syndrome (PMS) is a recurrent cyclic disorder of cyclical changes in the sexual hormones.It characterized by emotional, mental and physical symptoms, however pathophysiology largely unknown.Treatment with drugs like antidepressants, oral contraceptives, GRH agonist has been tried.Recently it shown that levels 25-hydroxyvitamin D 3 electrolytes such as magnesium have much importance controlling symptoms PMS.OBJECTIVE: To determine serum 25-hydroxy cholecalciferol...
The coronavirus disease 2019 (COVID-19) pandemic is placing extraordinary strains not only on hospital-wide systems but most especially hospital medicine across the nation. specific challenges faced by our hospitalist services are unfathomable. Hospitalist leaders tasked to rapidly restructure clinical operations accommodate large surge in COVID-19 patients. In this perspective, we focus management strategies conducted Division of Hospital Medicine tackle major crisis that specifically...
Capecitabine is an oral fluoropyrimidine carbamate chemotherapy agent approved by the United States Food and Drug Administration (FDA) for treatment of metastatic colorectal breast cancer. The common side effects associated with it include gastrointestinal (GI) upset, abdominal pain, palmar-plantar erythrodysesthesia, fatigue, alopecia, leukopenia, neutropenia, thrombocytopenia, anemia, hyperbilirubinemia. Although GI symptoms are relatively common, enterocolitis one rare this drug. We...
Objectives: To investigate blood glucose regulaitng effects of CatharanthusRoseus (C.roseus) and Nigella sativa (N.sativa) in alloxan induced diabetic rats. Study Design:Experimental study. Place Duration: Animal house Isra University Hyderabad. From Aprilto Novermber 2013. Methodology: 50 male rats were housed at normal température, 12 hourdark - light cycle with free access to chow water. A single intraperitoneal bolus alloxan(120 mg/kg) was given induce diabetes mellitus. Glimepiride, C....
Abstract The ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1), also known as plasma cell (PC) alloantigen (PC-1), is expressed on PCs and many non-lymphoid tissues. ENPP1 hydrolyzes NTP to generate NMP pyrophosphate (PPi). PPi an important factor for controlling mineralization of the bone. In addition, directly associates with insulin receptor regulates signaling. Abnormal expression has been associated diabetes resistance. Although was first identified in PCs, its function B...