A5009116940- Inflammatory mediators and NSAID effects
- Gastric Cancer Management and Outcomes
- Hearing Loss and Rehabilitation
- Cancer, Lipids, and Metabolism
- Colorectal Cancer Screening and Detection
- Pancreatic and Hepatic Oncology Research
- Noise Effects and Management
- Eicosanoids and Hypertension Pharmacology
- Colorectal Cancer Treatments and Studies
- Communication in Education and Healthcare
- Congenital heart defects research
- Childhood Cancer Survivors' Quality of Life
- Neuroendocrine Tumor Research Advances
- Palliative Care and End-of-Life Issues
- Neuroblastoma Research and Treatments
- Wnt/β-catenin signaling in development and cancer
- Pancreatic function and diabetes
- GDF15 and Related Biomarkers
- Neuroscience and Music Perception
- Hearing Impairment and Communication
- Neurogenetic and Muscular Disorders Research
- Diagnosis and Treatment of Venous Diseases
- COVID-19 and healthcare impacts
- Macrophage Migration Inhibitory Factor
- Hearing, Cochlea, Tinnitus, Genetics
University of Manchester
2020-2024
Manchester Academic Health Science Centre
2020-2024
Massachusetts General Hospital
2012-2022
Harvard University
2013-2022
NIHR Manchester Biomedical Research Centre
2020-2021
Harvard Stem Cell Institute
2012-2013
National Human Genome Research Institute
2003-2009
National Institutes of Health
2003
Marquette University
1980
Wnts are secreted signaling molecules that can transduce their signals through several different pathways. Wnt-5a is considered a noncanonical Wnt as it does not signal by stabilizing beta-catenin in many biological systems. We have uncovered new pathway which antagonizes the canonical promoting degradation of beta-catenin. This Siah2 and APC dependent, but GSK-3 beta-TrCP independent. Furthermore, we provide evidence also acts vivo to promote regulating mammalian limb development possibly...
Colonoscopy for colorectal cancer screening is endoscopist dependent, and colonoscopy quality improvement programs aim to improve efficacy. This study evaluated the clinical benefit safety of using a computer-aided detection (CADe) device in procedures.This randomized prospectively use CADe at 5 academic community centers by US board-certified gastroenterologists (n = 22). Participants aged ≥40 scheduled or surveillance (≥3 years) were included; exclusion criteria included incomplete...
Diabetes is a pathological condition characterized by relative insulin deficiency, persistent hyperglycemia, and, consequently, diffuse micro- and macrovascular disease. One therapeutic strategy to amplify insulin-secretion capacity increasing the number of insulin-producing β cells without triggering generalized proliferative response. Here, we present development small-molecule screening platform for identification molecules that increase β-cell replication. Using this platform, identify...
Vertebrate limb development is controlled by three signaling centers that regulate patterning and growth along the proximodistal (PD), anteroposterior (AP) dorsoventral (DV) axes. Coordination of these axes achieved interactions feedback loops involving secreted molecules mediate activities centers. However, it unknown how are processed in responding cells. We have found distinct LIM homeodomain transcription factors, encoded homeobox (LIM-HD) genes Lhx2, Lhx9 Lmx1b integrate events link...
Specialty palliative care (PC) is underused for patients with end‐stage liver disease (ESLD). We sought to examine attitudes of hepatologists and gastroenterologists about PC ESLD. conducted a cross‐sectional survey these specialists who provide Participants were recruited from the American Association Study Liver Diseases membership directory. Using questionnaire adapted prior studies, we examined physicians’ whether varied based on patients’ candidacy transplantation. identified predictors...
Low-dose aspirin is recommended by the U.S. Preventive Services Task Force for primary prevention of colorectal cancer in certain individuals. However, broader implementation will require improved precision approaches to identify those most likely benefit. The major urinary metabolite PGE2, 11α-hydroxy-9,15-dioxo-2,3,4,5-tetranor-prostane-1,20-dioic acid (PGE-M), a biomarker risk, but it unknown whether PGE-M modifiable individuals at risk cancer. Adults (N = 180) who recently underwent...
Although aspirin is recommended for the prevention of colorectal cancer, specific individuals whom benefits outweigh risks are not clearly defined. Moreover, precise mechanisms by which reduces risk cancer unclear. We recently launched ASPirin Intervention REDuction (ASPIRED) trial to address these uncertainties. ASPIRED a prospective, double-blind, multidose, placebo-controlled, biomarker clinical use in previously diagnosed with adenoma. Individuals (n = 180) will be randomized 1:1:1 ratio...
Objective Pupillometry is sensitive to cognitive resource allocation and has been used as a potential measure of listening-related effort fatigue. We investigated associations between peak pupil diameter, pre-stimulus performance on listening task, the dimensionality self-reported outcomes (task-related fatigue).Design was recorded while participants performed speech-in-noise task. Participants rated their experience fatigue using NASA-Task Load Index (NASA-TLX) Visual Analogue Scale Fatigue...
Kochar, Bharati MD, MSCR1,2; Ufere, Nneka N. MD1,2; Nipp, Ryan MPH2,3; Gustafson, Jenna L. MS1; Carolan, Peter MD1; Ritchie, Christine S. MSPH2,4 Author Information
Objective Listening effort (LE) varies as a function of listening demands, motivation and resource availability, among other things. Motivation is posited to have greater influence on under high, compared low, demands. Methods To test this prediction, we manipulated the demands speech recognition task using tone vocoders create moderate high demand conditions. We evaluative threat, i.e., informing participants that they must reach particular “score” for their results be usable. Resource...
Objectives To investigate the effects of listening demands and motivation on effort (LE) in a novel speech recognition task.Design We manipulated using vocoded financial reward, respectively, measured task performance (correct response rate) indices LE (response times (RTs), subjective ratings likelihood giving up). Effects inter-individual differences cognitive skills personality were also assessed within context Cognitive Energetics Theory (CET).Study sample Twenty-four participants with...
Abstract Background and study aims Conscious sedation is routinely administered for colonoscopy but associated with risks inconveniences. We sought to determine whether virtual reality (VR) may be a feasible alternative. Patients methods Twenty-seven individuals scheduled screening/surveillance participated. The VR device was activated throughout the colonoscopy, subjects could opt out request standard medications. Questionnaires were administered, variables assessed on scale of 1 10....
Delays in inpatient colonoscopy are commonly caused by inadequate bowel preparation and result increased hospital length of stay (LOS) healthcare costs. Low-volume (LV-BP; sodium sulfate, potassium magnesium sulfate ) has been shown to improve outpatient quality compared with standard high-volume preparations (HV-BP; polyethylene glycol ). However, its efficacy hospitalized patients not well-studied. We assessed the impact LV-BP on time colonoscopy, LOS, among inpatients.We performed a...
<div>Abstract<p>Low-dose aspirin is recommended by the U.S. Preventive Services Task Force for primary prevention of colorectal cancer in certain individuals. However, broader implementation will require improved precision approaches to identify those most likely benefit. The major urinary metabolite PGE<sub>2</sub>, 11α-hydroxy-9,15-dioxo-2,3,4,5-tetranor-prostane-1,20-dioic acid (PGE-M), a biomarker risk, but it unknown whether PGE-M modifiable individuals at risk...
<div>Abstract<p>Low-dose aspirin is recommended by the U.S. Preventive Services Task Force for primary prevention of colorectal cancer in certain individuals. However, broader implementation will require improved precision approaches to identify those most likely benefit. The major urinary metabolite PGE<sub>2</sub>, 11α-hydroxy-9,15-dioxo-2,3,4,5-tetranor-prostane-1,20-dioic acid (PGE-M), a biomarker risk, but it unknown whether PGE-M modifiable individuals at risk...
<p>Supplemental Methods, References, Figure, and Tables</p>
<p>Supplemental Methods, References, Figure, and Tables</p>