A5011292171- Lanthanide and Transition Metal Complexes
- Advanced MRI Techniques and Applications
- Medical Imaging Techniques and Applications
- Magnetism in coordination complexes
- Liver Disease Diagnosis and Treatment
- Radioactive element chemistry and processing
- Radiopharmaceutical Chemistry and Applications
- Hepatocellular Carcinoma Treatment and Prognosis
- MRI in cancer diagnosis
- X-ray Diffraction in Crystallography
- Liver physiology and pathology
- Crystallization and Solubility Studies
- Dendrimers and Hyperbranched Polymers
- Mass Spectrometry Techniques and Applications
- Advanced Proteomics Techniques and Applications
- Metal complexes synthesis and properties
- Pancreatic and Hepatic Oncology Research
- Transcranial Magnetic Stimulation Studies
- Atomic and Subatomic Physics Research
- RNA Interference and Gene Delivery
- Chemical Thermodynamics and Molecular Structure
- Neuroscience and Neural Engineering
- Liver Disease and Transplantation
- Click Chemistry and Applications
- Biochemical and Molecular Research
Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry
2022-2025
Czech Academy of Sciences
2024
University of Chemistry and Technology, Prague
2024
Czech Academy of Sciences, Nuclear Physics Institute
2018
Athinoula A. Martinos Center for Biomedical Imaging
2012-2017
Harvard University
2012-2017
Massachusetts General Hospital
2012-2017
Charles University
2004-2012
University of Coimbra
2009
Delft University of Technology
2009
Electrical stimulation is currently used to treat a wide range of cardiovascular, sensory and neurological diseases. Despite its success, there are significant limitations application, including incompatibility with magnetic resonance imaging, limited control electric fields decreased performance associated tissue inflammation. Magnetic overcomes these but existing devices (that is, transcranial stimulation) large, reducing their translation chronic applications. In addition, not effective...
MR imaging at high magnetic fields benefits from an increased signal-to-noise ratio; however T1-based contrast agents show decreasing relaxivity (r1) higher fields. High field, can be designed by carefully controlling the rotational dynamics of molecule. To this end, we investigated applications alanine analogue Gd(DOTA), Gd(DOTAla). Fmoc-protected DOTAla suitable for solid phase peptide synthesis was synthesized and integrated into polypeptide structures. Gd(III) coordination results in...
Gadolinium chelates with octadentate ligands are widely used as contrast agents for magnetic resonance imaging (MRI), macrocyclic based on DO3A being preferred the high kinetic inertness of their Gd chelates. A major challenge in design new bifunctional MRI probes is need to control rotational motion chelate, which greatly affects its relaxivity. In this work we explored facile alkylation a secondary amine DO3A-like create short, achiral linkage limit undesired internal within larger...
Abstract Perfusion dynamics play a vital role in delivering essential nutrients and oxygen to tissues while removing metabolic waste products. Imaging techniques such as magnetic resonance imaging (MRI), computed tomography (CT), positron emission (PET) use contrast agents visualize perfusion clearance patterns; however, each technique has specific limitations. Hybrid PET/MRI combines the quantitative power sensitivity of PET with high functional anatomical detail MRI holds great promise for...
The replacement of one the acetate pendant arms with a 2-methylpyridine-N-oxide group in molecule H4dota significantly alters coordination properties ligand Ln(III) complexes. structural complexes are investigated both solution and solid state. variable-temperature 1H NMR spectra Nd(III), Eu(III), Yb(III) show that twisted-square-antiprismatic (TSA) isomer is strongly destabilized suppressed exist mostly as square-antiprismatic (SA) isomers (98% for Eu(III) at -35 degrees C). exchange...
Fibrosis with excessive amounts of type I collagen is a hallmark many solid tumours, and fibrosis promising target in cancer therapy, but tools for its non-invasive quantification are missing. Here we used magnetic resonance imaging gadolinium-based probe targeted to (EP-3533) image quantify pancreatic ductal adenocarcinoma. An orthotopic syngeneic mouse model resulted tumours 2.3-fold higher level compared healthy pancreas. Animals were scanned at 4.7 T before, during up 60 min after i.v....
Two macrocyclic ligands derived from H4dota containing three acetate pendant arms and one 2-methylpyridine-N-oxide coordinating unit were synthesized. The ligand H3do3apyNO (H3L1, 10-[(1-oxidopyridin-2-yl)methyl]-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid) contains an unsubstituted pyridine-N-oxide ring; the H4do3apyNO-C (H4L2, 10-[(4-carboxy-1-oxidopyridin-2-yl)methyl]-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic is functionalized with a carboxylic group in 4 position of pyridine...
A pyridine-N-oxide functionalized DOTA analogue has been conjugated to a calix[4]arene and the corresponding Gd-complex was characterized with respect its suitability as MRI contrast agent. The compound forms spherical micelles in water cmc of 35 μM radius 8.2 nm. relaxivity these aggregates is 31.2 s−1 mM−1 at 25 °C 20 MHz, which corresponds molecular 125 mM−1. high mainly originates from short τM (72.7 ns) size micelles. interaction bovine serum albumin (BSA) studied an observed up 40.8...
A bifunctional ligand, DO3A-pyNO-C (DO3A-pyNO-C = 10-[(4-carboxy-1-oxidopyridin-2-yl)methyl]-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid), was attached to different generations (G0, G1, G2, and G4) of ethylenediamine-cored PAMAM dendrimers (PAMAM polyamidoamine). The gadolinium(III) complex this ligand possesses one molecule water in its first coordination sphere has a unique combination short residence lifetime (τM 34 ns), neutral overall charge, possibility for rigid attachment...
Abstract Contactless digital tags are increasingly penetrating into many areas of human activities. Digitalization our environment requires an ever growing number objects to be identified and tracked with machine-readable labels. Molecules offer immense potential serve for this purpose, but ability write, read, communicate molecular code current technology remains limited. Here we show that magnetic patterns can synthetically encoded stable scaffolds paramagnetic lanthanide ions write...
The presence of a six-membered chelate ring involving pyridine N-oxide moiety induces exclusive M isomer formation throughout the whole lanthanide series endowed with fast water exchange in case Gd(III) complex.
<title>Abstract</title> Coordination compounds of lanthanides are indispensable in biomedical applications as MRI contrast agents and radiotherapeutics. However, since the introduction chelator DOTA four decades ago, there has been only limited progress on improving their thermodynamic stability kinetic inertness, which essential for safe <italic>in-vivo</italic> use. Here, we present ClickZip, an innovative synthetic strategy employing a coordination-templated formation...
Abstract Coordination compounds of lanthanides are indispensable in biomedical applications as MRI contrast agents and radiotherapeutics. However, since the introduction chelator DOTA four decades ago, there has been only limited progress on improving their thermodynamic stability kinetic inertness, which essential for safe vivo use. Here, we present ClickZip, an innovative synthetic strategy employing a coordination-templated formation 1 ,5 -triazole bridge that improves inertness up to...
Abstract Die Perfusionsdynamik spielt eine entscheidende Rolle bei der Versorgung des Gewebes mit lebenswichtigen Nährstoffen und Sauerstoff Abführung von Stoffwechselendprodukten. Bildgebende Verfahren wie die Magnetresonanztomographie (MRT), Computertomographie (CT) Positronen‐Emissions‐Tomographie (PET) verwenden Kontrastmittel, um Perfusions‐ Ausscheidungsmuster sichtbar zu machen. Hybrid‐PET/MRT kombiniert quantitativen Möglichkeiten Empfindlichkeit PET hohen funktionellen anatomischen...
Motivation: Our work is driven by the conviction that integration of PET and MRI in molecular imaging has potential to revolutionize diagnostic precision patient care. Goal(s): Enhance through development a unique hybrid PET/MRI perfusion probe, [18F][Gd(FL1)]. Approach: Develop [18F][Gd(FL1)], exceptionally stable, rapidly synthesized, efficiently radiolabeled, allows simultaneous PET/MR imaging, focusing on tissue renal filtration preclinical models. Results: After achieving high-yield...