A5041587523- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Metal complexes synthesis and properties
- Boron Compounds in Chemistry
- Radioactive element chemistry and processing
- Lanthanide and Transition Metal Complexes
- Crystal structures of chemical compounds
- Sphingolipid Metabolism and Signaling
- Carbohydrate Chemistry and Synthesis
- Magnetism in coordination complexes
- Crystallography and molecular interactions
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and biological activity
- Pharmacological Effects and Toxicity Studies
- Metal-Organic Frameworks: Synthesis and Applications
- Radiopharmaceutical Chemistry and Applications
- Lysosomal Storage Disorders Research
- Organometallic Compounds Synthesis and Characterization
- Boron and Carbon Nanomaterials Research
- Organoboron and organosilicon chemistry
- Organometallic Complex Synthesis and Catalysis
- Multicomponent Synthesis of Heterocycles
- Catalytic C–H Functionalization Methods
- Ferrocene Chemistry and Applications
- Supramolecular Self-Assembly in Materials
Czech Academy of Sciences, Institute of Inorganic Chemistry
2021-2025
Akademie (Czechia)
2025
Czech Academy of Sciences
2025
University of Pavol Jozef Šafárik
2017-2020
Institute of Chemistry of the Slovak Academy of Sciences
2020
Technical University of Košice
2017
A series of palladium(II) complexes with derivatives 8‐hydroxyquinoline (HXQ) composition NH2(CH3)2[PdCl2(XQ)] where HXQ is 5‐nitro‐7‐iodo‐8‐hydroxyquinoline (HNIQ) (1a), 5‐nitro‐7‐bromo‐8‐hydroxyquinoline (HNBrQ) (2a), 5‐iodo‐7‐bromo‐8‐hydroxyquinoline (HIBrQ) (3a) and 5‐chloro‐7‐bromo‐8‐hydroxyquinoline (HClBrQ) (4a) was prepared. Upon their dissolution in DMSO, [PdCl(DMSO)(XQ)] (1b‐4b) [Pd(XQ)2] (1c‐4c) were prepared as a consequence ligand exchange. The the elucidated by infrared NMR...
Luminescence is observed in three novel macropolyhedral nineteen- and eighteen-vertex chalcogenaboranes: Se
A metal-free, user-friendly photochemical transformation of nitroalkanes to oximes, nitrones, and hydroxylamines has been developed. The visible-light-induced reactions are catalyzed by the readily available photoredox organocatalyst 4CzIPN use inexpensive amines as reductants. Broad in scope tolerant multiple functional groups heterocycles, proceeds under mild conditions. Its synthetic potential was demonstrated formal total synthesis amathaspiramide F. basic insight into reaction mechanism...
Several novel copper (II) complexes of reduced Schiff bases containing fluoride substituents were prepared and structurally characterized by single-crystal X-ray diffraction. The exhibited diverse structures, with the central atom in distorted tetrahedral geometry. biological effects products evaluated, specifically their cytotoxicity, antimicrobial, antiurease activities, as well affinity for albumin (BSA) DNA (ct-DNA). showed marked cytotoxic activities HepG2 hepatocellular carcinoma cell...
Platinum compounds remain the first-line drugs for treatment of most lethal gynecological malignancies and ovarian cancers. Acquired platinum resistance remains a major challenge in oncology. Considering unique physicochemical properties metallacarboranes modifier significant role nucleoside derivatives as anticancer antimetabolites, we designed synthesized set adenosine conjugates with containing iron, cobalt, or chromium semi-abiotic that influence cisplatin sensitivity cancer cells....
Two tetranuclear [Zn4Cl2(ClQ)6]·2DMF (1) and [Zn4Cl2(ClQ)6(H2O)2]·4DMF (2), as well three dinuclear [Zn2(ClQ)3(HClQ)3]I3 (3), [Zn2(dClQ)2(H2O)6(SO4)] (4) [Zn2(dBrQ)2(H2O)6(SO4)] (5), complexes (HClQ = 5-chloro-8-hydroxyquinoline, HdClQ 5,7-dichloro-8-hydroxyquinoline HdBrQ 5,7-dibromo-8-hydroxyquinoline) were prepared possible anticancer or antimicrobial agents characterized by IR spectroscopy, elemental analysis single crystal X-ray structure analysis. The stability of the in solution was...
Ruthenium complexes currently represent a perspective subject of investigation in terms potential anticancer therapeutics. Eight novel octahedral ruthenium(II) are the this article. Complexes contain 2,2'-bipyridine molecules and salicylates as ligands, differing position type halogen substituent. The structure was determined via X-ray structural analysis NMR spectroscopy. All were characterized by spectral methods-FTIR, UV-Vis, ESI-MS. show sufficient stability solutions. Therefore, their...
Abstract Luminescence is observed in three novel macropolyhedral nineteen‐ and eighteen‐vertex chalcogenaboranes: Se 2 B 17 H ( 1 ), SeB 19 3 ) 18 20 4 ). This led us to the recognition that previously published heteroborane species might also exhibit luminescence. Thus, known dithiaboranes S n ‐S 16 5 i 6 were synthesised found a range of luminescent properties. These are very different from unique fluorescent binary borane 22 terms their structural architectures, by presence cluster hetero...
Abstract Herein, we present the preparation of a series electronically and/or sterically distinct borenium‐type species based on simple 2‐arylpyridine scaffold. Corresponding arylpyridine was firstly subjected to electrophilic borylation (BBr 3 / i‐ Pr 2 NEt) and formed BBr chelate reduced with LiAlH 4 yield boron dihydride. Elimination one hydride led Lewis acidic borenium‐like products. Four methods elimination were evaluated influence counterions reactivity, luminescent properties...
Abstract Coordination compounds of lanthanides are indispensable in biomedical applications as MRI contrast agents and radiotherapeutics. However, since the introduction chelator DOTA four decades ago, there has been only limited progress on improving their thermodynamic stability kinetic inertness, which essential for safe vivo use. Here, we present ClickZip, an innovative synthetic strategy employing a coordination-templated formation 1 ,5 -triazole bridge that improves inertness up to...
Toxic metal (Cd2+, Hg2+, Pb2+, and Ag+) complexes with the tetradentate macrocyclic ligand - cyclen (1,4,7,10-tetraazacyclododecane, [12]aneN4, L) were prepared studied in solid state by IR, X-ray diffraction, elemental thermal analysis. Diffraction results have yielded three molecular structures, [Cd([12]ane-κ4N1,4,7,10)(NO3)2)] (1), [Hg([12]ane-κ4N1,4,7,10)(NO3-κ2O,O`)]NO3 (2), [Pb2([12]ane-κ4N1,4,7,10)2][Pb(NO3)6] (3) one polymeric structure...
A series of Schiff base ligands obtained by the condensation trans-cyclohexane-1,2-diamine and fluorinated benzaldehydes were prepared, followed their reduction with NaBH4. The reduced employed in synthesis zinc complexes general formula [ZnCl2(L)]. structures both original bases, as well complexes, characterized single-crystal X-ray analysis, along NMR IR spectroscopy. antimicrobial activities bases evaluated vitro against E. coli, S. aureus, C. albicans. compounds containing...
Carbon substituted cobalt bis(dicarbollide) alkyl halides [(1-X-(CH
High yields of novel macropolyhedral selenaboranes are reported. Reactions the monoanions syn- and anti-isomers B18H22 with powdered selenium in THF variously give new selenaboranes: 19-vertex [SeB18H19]- anion 1, [SeB18H21]- 2, 20-vertex [Se2B18H19]- 3, [Se2B17H18]- 4. Single-cluster [hypho-Se2B6H9]- 5 neutral arachno-Se2B7H96 also result. All macropolyhedrals 4 characterized by NMR spectroscopy mass spectrometry, single-crystal X-ray diffraction analyses. Anions 1 2 each consist an...
The action of AlCl3 on room-temperature tetrachloromethane solutions anti-B18H22 (1) results in a mixture fluorescent isomers, 3,3′-Cl2-B18H20 (2) and 3,4′-Cl2-B18H20 (3), together isolated 76% yield. Compounds 2 3 are capable the stable emission blue light under UV-excitation. In addition, small amounts other dichlorinated 4,4′-Cl2-B18H20 (4), 3,1′-Cl2-B18H20 (5), 7,3′-Cl2-B18H20 (6) were isolated, along with blue-fluorescent monochlorinated derivatives, 3-Cl-B18H21 (7) 4-Cl-B18H21 (8),...
Six new copper(II) complexes were prepared: [Cu(ClBrQ)2] (1a, 1b), [Cu(ClBrQ)2]·1/2 diox (2) (diox = 1,4-dioxane), [Cu(BrQ)2] (3), [Cu(dNQ)2] (4), [Cu(dNQ)2(DMF)2] (5) and [Cu(ClNQ)2] (6), where HClBrQ is 5-chloro-7-bromo-8-hydroxyquinoline, HBrQ 7-bromo-8-hydroxyquinoline, HClNQ 5-chloro-7-nitro-8-hydroxyquinoline HdNQ 5,7-dinitro-8-hydroxyquinoline. Prepared compounds characterised by infrared spectroscopy, elemental analysis X-ray structural analysis. Structural revealed that all are...
The interaction of aminomethylphosphonic acid with the Zn(<sc>ii</sc>)–cyclen complex was evaluated by an original combination potentiometry and multinuclear NMR.