A5063380698- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Metal complexes synthesis and properties
- Cancer therapeutics and mechanisms
- Synthesis and Characterization of Heterocyclic Compounds
- Bioactive Compounds and Antitumor Agents
- Crystal structures of chemical compounds
- Synthesis and Biological Evaluation
- Nanocomposite Films for Food Packaging
- Skin Protection and Aging
- Ferrocene Chemistry and Applications
- Click Chemistry and Applications
- Free Radicals and Antioxidants
- Piperaceae Chemical and Biological Studies
- Biocrusts and Microbial Ecology
- Synthesis and biological activity
- Bee Products Chemical Analysis
- Contact Dermatitis and Allergies
- Crystallography and molecular interactions
University of Pavol Jozef Šafárik
2021-2024
University of Veterinary Medicine in Košice
2023-2024
Institute of Chemistry of the Slovak Academy of Sciences
2023
Two tetranuclear [Zn4Cl2(ClQ)6]·2DMF (1) and [Zn4Cl2(ClQ)6(H2O)2]·4DMF (2), as well three dinuclear [Zn2(ClQ)3(HClQ)3]I3 (3), [Zn2(dClQ)2(H2O)6(SO4)] (4) [Zn2(dBrQ)2(H2O)6(SO4)] (5), complexes (HClQ = 5-chloro-8-hydroxyquinoline, HdClQ 5,7-dichloro-8-hydroxyquinoline HdBrQ 5,7-dibromo-8-hydroxyquinoline) were prepared possible anticancer or antimicrobial agents characterized by IR spectroscopy, elemental analysis single crystal X-ray structure analysis. The stability of the in solution was...
Silver( i ) complexes show antibacterial and cytotoxic activity in ovo experiments predict their safe use for local or intravenous applications. Fluorescence quenching lipophilicity indicate suitable bioavailability.
Abstract DNA topoisomerases regulate conformational changes in topology during normal cell growth, such as replication, transcription, recombination, and repair, may be targeted for anticancer drugs. A assay was used to investigate DNA-damaging/protective activities of extracts from Habanero Red (HR), Maya (HMR), Trinidad Moruga Scorpion (TMS), Jalapeno (J), Serrano pepper (SP), Savina (HRS), Bhut Jolokia (BJ), Jamaica Rosso (JR) peppers, demonstrating their inhibitory effect on the...
Three silver(I) dipeptide complexes [Ag(GlyGly)]n(NO3)n (AgGlyGly), [Ag2(GlyAla)(NO3)2]n (AgGlyAla) and [Ag2(HGlyAsp)(NO3)]n (AgGlyAsp) were prepared, investigated characterized by vibrational spectroscopy (mid-IR), elemental thermogravimetric analysis mass spectrometry. For AgGlyGly, X-ray crystallography was also performed. Their stability in biological testing media verified time-dependent NMR measurements. vitro antimicrobial activity evaluated against selected pathogenic microorganisms....
Abstract A series of novel Ga(III)—pyridine carboxylates ([Ga(Pic) 3 ]·H 2 O (GaPic; HPic = picolinic acid), H O[Ga(Dpic) (GaDpic; Dpic dipicolinic [Ga(Chel)(H O)(OH)] ·4H (GaChel; Chel chelidamic acid) and [Ga(Cldpic)(H (GaCldpic; Cldpic 4-chlorodipicolinic acid)) have been synthesized by simple one-step procedure. Vibrational spectroscopy (mid-IR), elemental analysis, thermogravimetric analysis X-ray diffraction confirmed complexes molecular structure, inter intramolecular interactions...
Abstract In the cosmetic industry there is an increasing demand for substances obtained from natural sources that can replace synthetic ones. Due to consumer a protective filter with (SPF) labels in sunscreens, moisturizers, face make-up, and lipsticks worldwide, they produce tonnes of such products every year. Many species cyanobacteria live extreme environments, including sites excessive doses sunlight drought. To survive conditions, compounds allow both protection against ultraviolet...
Four new zinc(II) complexes containing molecules of 5-chloro-7-nitro-8-hydroxyquinoline (HClNQ), NH2(CH3)2[Zn(ClNQ)3]·DMF (1), K[Zn(ClNQ)3]·2DMF (2), {Na[Zn(ClNQ)(SO4)(H2O)]} n (3) and [Zn(ClNQ)2(H2O)2] (4), were prepared characterized by IR NMR spectroscopy, elemental analysis single crystal X-ray analysis. Ionic 1 2 have similar structures, in which Zn(II) atoms are coordinated three chelate ClNQ via oxygen nitrogen donor forming rare fac isomers. The negative charge the complex anions is...
Abstract This study aimed to explain the effect of extracts from chili pepper varieties containing capsaicin and dihydrocapsaicin, among other substances, on growth colon cancer in humans through therapeutic research drug screening. DNA topoisomerases regulate conformational changes topology during normal cell growth, such as replication, transcription, recombination, repair, may be targeted for anticancer drugs. A assay was used investigate DNA-damaging/protective activities Habanero Red...
Abstract The aim of this study was to evaluate the antibacterial activity, quality and stability creams (at 1 % concentration) prepared with synthesized silver(I) complexes: [Ag(Nam) 2 ]NO 3 ·H O ( AgNam), [Ag (HGly) ] n (NO ) 2n (AgGly) (Nam – nicotin-amide, Gly glycine) sulfadiazine (AgSD), which is commercially available. Antibacterial activity evaluated by agar well diffusion method in vivo case. pure complexes as all three tested loaded AgGly, AgSD AgNam showed potential. Moreover,...