A5010590002- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Metal complexes synthesis and properties
- Synthesis and biological activity
- Cancer therapeutics and mechanisms
- Crystal structures of chemical compounds
- Bioactive Compounds and Antitumor Agents
- Organometallic Compounds Synthesis and Characterization
- Lanthanide and Transition Metal Complexes
- Synthesis and Biological Evaluation
- Synthesis and Characterization of Heterocyclic Compounds
- Metal-Organic Frameworks: Synthesis and Applications
- Carbohydrate Chemistry and Synthesis
- Lichen and fungal ecology
- Quinazolinone synthesis and applications
- Protein Interaction Studies and Fluorescence Analysis
- Synthetic Organic Chemistry Methods
- Genomics, phytochemicals, and oxidative stress
- Chemical Synthesis and Analysis
- Synthesis and Reactivity of Heterocycles
- Multicomponent Synthesis of Heterocycles
- Ionic liquids properties and applications
- Chemical synthesis and alkaloids
- Synthesis of heterocyclic compounds
- Garlic and Onion Studies
University of Pavol Jozef Šafárik
2016-2025
Institute of Chemistry of the Slovak Academy of Sciences
2015-2024
Technical University of Košice
2017-2021
Gdańsk University of Technology
2020
Institute of Chemistry
2016
University of Turku
2006
Free radicals play a critical role in the chemical processes that occur all cells. Pharmaceutical companies manufacture variety of synthetically prepared antioxidants, but it is known many these can be carcinogenic. As result, efforts are being made to find natural antioxidants do not have side effects. Lichens may suitable candidates because they contain secondary metabolites with proven antioxidant properties. This could explained by presence compounds phenolic groups lichens. The radical...
A series of palladium(II) complexes with derivatives 8‐hydroxyquinoline (HXQ) composition NH2(CH3)2[PdCl2(XQ)] where HXQ is 5‐nitro‐7‐iodo‐8‐hydroxyquinoline (HNIQ) (1a), 5‐nitro‐7‐bromo‐8‐hydroxyquinoline (HNBrQ) (2a), 5‐iodo‐7‐bromo‐8‐hydroxyquinoline (HIBrQ) (3a) and 5‐chloro‐7‐bromo‐8‐hydroxyquinoline (HClBrQ) (4a) was prepared. Upon their dissolution in DMSO, [PdCl(DMSO)(XQ)] (1b‐4b) [Pd(XQ)2] (1c‐4c) were prepared as a consequence ligand exchange. The the elucidated by infrared NMR...
This paper was aimed to investigate the possible implications of lack plastidic glutamine synthetase (GS2) in phenolic metabolism during stress responses model legume Lotus japonicus. Important changes transcriptome were detected a GS2 mutant called Ljgln2-2, compared wild type, response two separate conditions, such as drought or result impairment photorespiratory cycle. Detailed transcriptomic analysis showed that biosynthesis compounds affected plants these different types situations. For...
Chalcones are naturally occurring phytochemicals with diverse biological activities including antioxidant, antiproliferative, and anticancer effects. Some studies indicate that the antiproliferative effect of chalcones may be associated their pro-oxidant effect. In present study, we evaluated contribution oxidative stress in acridine chalcone 1C ((2 E)-3-(acridin-9-yl)-1-(2,6-dimethoxyphenyl)prop-2-en-1-one) human colorectal HCT116 cells. We demonstrated induced via increased reactive...
Two novel amorphous metal–organic frameworks <bold>UPJS-13</bold> and <bold>UPJS-14</bold>, constructed of Zn(<sc>ii</sc>)/Cd(<sc>ii</sc>) ions extended tetrahedral linker were prepared, characterised applied as adsorbents for carbon dioxide methane.
A series of novel acridine N-acylhydrazone derivatives have been synthesized as potential topoisomerase I/II inhibitors, and their binding (calf thymus DNA—ctDNA human serum albumin—HSA) biological activities anticancer agents on proliferation A549 CCD-18Co evaluated. The acridine-DNA complex 3b (-F) displayed the highest Kb value (Kb = 3.18 × 103 M−1). HSA-derivatives interactions were studied by fluorescence quenching spectra. This method was used for calculation characteristic parameters....
Ovarian cancer ranks among the most severe forms of affecting female reproductive organs, posing a significant clinical challenge primarily due to development resistance conventional therapies. This study investigated effects chalcone derivative 1C on sensitive (A2780) and cisplatin-resistant (A2780cis) ovarian cell lines. Our findings revealed that suppressed viability, induced cycle arrest at G2/M phase, triggered apoptosis in both These are closely associated with generating reactive...
The synthesis, anticancer, and antioxidant activities of a series indole-derived hybrid chalcones are reported here. First, using the well-known Claisen-Schmidt condensation method, set 29 has been designed, synthesized, consequently characterized. Subsequently, screening for antiproliferative activity synthesized was performed on five cancer cell lines (HCT116, HeLa, Jurkat, MDA-MB-231, MCF7) two non-cancer (MCF-10A Bj-5ta). Chalcone 18c, bearing 1-methoxyindole catechol structural...
Abstract magnified image Acridin‐9‐yl hydrazine upon treatment with various isothiocyanates (RNCS, R = methyl, allyl, phenyl, p ‐methoxy and ‐nitro phenyl) yielded the corresponding thiosemicarbazides acridine substituted on carbazide‐type side. The alkyl‐substituted compounds were present in solution as equilibria consisting of major H‐10, H‐12 tautomer (either E or Z both about C 13 ‐N 14 bond) minor SH both). species for aromatic‐substituted was tautomer, evident being tautomer. each...
The synthesis, anticancer and antioxidant activity of a series indole-derived hybrid chalcones are reported here. First, using well known Claisen-Schmidt condensation method set 29 has been designed, synthesized, consequently characterized. Subsequently, screening for the antiproliferative synthesized was performed on five cancer (HCT116, HeLa, Jurkat, MDA-MB-231 MCF7) two non-cancer (MCF-10A Bj-5ta) cell lines. Chalcone 18c bearing 1-methoxyindole catechol structural features, exhibited...