A5004161945- Cancer therapeutics and mechanisms
- Photodynamic Therapy Research Studies
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Bioactive Compounds and Antitumor Agents
- Cancer, Hypoxia, and Metabolism
- Nanoplatforms for cancer theranostics
- Drug Transport and Resistance Mechanisms
- Synthesis and biological activity
- Metal complexes synthesis and properties
- Epigenetics and DNA Methylation
- Synthesis and Biological Evaluation
- Click Chemistry and Applications
- Cancer, Stress, Anesthesia, and Immune Response
- Lichen and fungal ecology
- Cancer Cells and Metastasis
- Characterization and Applications of Magnetic Nanoparticles
- Cell death mechanisms and regulation
- Neurogenesis and neuroplasticity mechanisms
- Pharmacogenetics and Drug Metabolism
- Olfactory and Sensory Function Studies
- Bryophyte Studies and Records
- DNA and Nucleic Acid Chemistry
- Retinoids in leukemia and cellular processes
- Nuclear Receptors and Signaling
University of Pavol Jozef Šafárik
2015-2024
Cancer cell resistance, particularly multidrug resistance (MDR), is the leading cause of chemotherapy failure. A number mechanisms involved in development MDR have been described, including overexpression ATP-dependent membrane-bound transport proteins. The enhanced expression these proteins, referred to as ATP‑binding cassette (ABC) transporters, results an increased cellular efflux cytotoxic drug, thereby reducing its intracellular concentration ineffective level. Non-steroidal...
A series of novel acridine N-acylhydrazone derivatives have been synthesized as potential topoisomerase I/II inhibitors, and their binding (calf thymus DNA—ctDNA human serum albumin—HSA) biological activities anticancer agents on proliferation A549 CCD-18Co evaluated. The acridine-DNA complex 3b (-F) displayed the highest Kb value (Kb = 3.18 × 103 M−1). HSA-derivatives interactions were studied by fluorescence quenching spectra. This method was used for calculation characteristic parameters....
We report the synthesis of fine (∼ 5 nm) citric acid capped CoFe2O4 (CA-CoFe2O4) nanoparticles by coprecipitation method at different pH conditions that changes gradually from 6 to 11. Structural and magnetic characterization performed TEM, XRD SQUID confirm under lower (6 9) leads formation shell covering individual nanoparticles. Capping layer increases inter-particle distance what results in decrease interaction strength. On other hand, higher (10 11) apparently hampers proper that,...
Breast cancer resistance protein (BCRP) belongs to the family of ATP-binding cassette (ABC) transporters, overexpression which can confer a multidrug-resistant phenotype in cells and tumors. BCRP mediates efflux numerous xenobiotics, including various chemotherapeutic agents photosensitizers. Hypericin (HY) is naturally-occurring photosensitizer synthesized by plants genus Hypericum. Our recently published results indicate that accumulation HY different tissue origin be affected mostly BCRP....
Hypericin-mediated photodynamic therapy (HY-PDT) has recently captured increased attention as an alternative minimally invasive anticancer treatment, although cancer cells may acquire resistance. Therefore, combination treatments be necessary to enhance HY-PDT efficacy. Histone deacetylase inhibitors (HDACis) are often used in due their non-genotoxic properties and epigenetic potential sensitize external stimuli. this study attempts for the first time investigate therapeutic effects of...
A549 human lung carcinoma cell lines were treated with a series of new drugs both tacrine and coumarin pharmacophores (derivatives 1a–2c) in order to test the compounds’ ability inhibit cancer growth topoisomerase I II activity. The (hTOPI) relax supercoiled plasmid DNA presence various concentrations tacrine-coumarin hybrid molecules was studied agarose gel electrophoresis. biological activities derivatives using MTT assays, clonogenic cycle analysis quantification number viability. content...
Photodynamic therapy with hypericin (HY-PDT) and hyperforin (HP) could be treatment modalities for colorectal cancer (CRC), but evidence of their effect on angiogenic factors in CRC is missing. Convenient experimental model utilization essential angiogenesis research. Therefore, not only 2D cell models, also 3D models micro-tumors were used compared. The micro-tumor extent interconnection the chorioallantoic membrane (CAM) was determined by histological analyses. presence proliferating cells...