A5053395392- Lichen and fungal ecology
- Botany and Plant Ecology Studies
- Bryophyte Studies and Records
- Heavy metals in environment
- Mycorrhizal Fungi and Plant Interactions
- Biocrusts and Microbial Ecology
- Environmental Toxicology and Ecotoxicology
- Biological Control of Invasive Species
- Nail Diseases and Treatments
- Cancer Cells and Metastasis
- Pesticide and Herbicide Environmental Studies
- Drug Solubulity and Delivery Systems
- Ocular Surface and Contact Lens
- Geology and Paleoclimatology Research
- Bee Products Chemical Analysis
- Pharmaceutical and Antibiotic Environmental Impacts
- Geochemistry and Elemental Analysis
- Natural product bioactivities and synthesis
- Microbial Natural Products and Biosynthesis
- Allergic Rhinitis and Sensitization
- Nanoparticles: synthesis and applications
- Algal biology and biofuel production
- Advanced Drug Delivery Systems
- Heavy Metals in Plants
- Turfgrass Adaptation and Management
University of Veterinary Medicine in Košice
2015-2025
University of Veterinary Sciences Brno
2018
University of Pavol Jozef Šafárik
2009-2012
Comenius University Bratislava
1992-1998
Infections caused by Malassezia (M.) pachydermatis in dogs are mostly treated with azole antifungals. Excessive use of these drugs is usually associated an increased incidence resistant isolates, which can be prevented combining commonly used antifungals natural bioactive compounds. The present study aimed at testing the effectiveness a combination selected derivatives showing low antifungal activity against M. plant essential oil components displaying highest efficacy. Among four tested...
In the present work, phytotoxic effects of secondary metabolites extracted from five lichen species (Cladonia arbuscula var. mitis, Cladonia furcata, Hypogymnia physodes, Evernia prunastri and Ramalina farinacea) on cultures aposymbiotically grown photobiont Trebouxia erici were evaluated. Toxicity single metabolites, as well their naturally occurred mixtures in lichens was tested at two selected doses, 0.1 mg/disk 0.01 mg/disk. Application all decreased growth cells a dose dependent manner....
Peltigera rufescens (Weis) Humb. with a prokaryotic photobiont Nostoc sp. and Cladina arbuscula subsp. mitis (Sandst.) Ruoss eukaryotic Trebouxia were studied to determine the copper sensitivity of lichens different algal symbionts. Samples growing on historic mine-spoil heaps at Ľubietová–Podlipa, Slovakia assessed for physiological parameters, including total intracellular uptake copper, assimilation pigmentation, activity photosystem II, ergosterol levels, thiobarbituric acid reactive...
Natural products include a diverse set of compounds drug discovery that are currently being actively used to target tumor angiogenesis. In the present study, we evaluated anti-angiogenic activities secondary metabolite usnic acid isolated from Usena antarctica. We investigated in vitro effects on proliferation, migration, and tube formation VEGF- bFGF-stimulated HUVECs. Ex ovo activity was using CAM assay. Our findings demonstrated concentration 33.57 µM inhibited VEGF (25 ng/mL) bFGF (30...
Abstract The quantitative response to two lichen metabolites, vulpinic acid and (+) usnic acid, on biomass production by the photobiont Trebouxia irregularis , isolated from Cladina mitis was determined experimentally. presence of resulted in inhibition growth, effect depended pH culture medium. concentration observed. application almost completely inhibited growth T.irregularis no significant differences were found among samples at different medium values.
Abstract The quantitative response to two lichen metabolites, vulpinic acid and (+) usnic acid, on biomass production by the photobiont Trebouxia irregularis , isolated from Cladina mitis was determined experimentally. presence of resulted in inhibition growth, effect depended pH culture medium. concentration observed. application almost completely inhibited growth T.irregularis no significant differences were found among samples at different medium values.
Lichens comprise a number of unique secondary metabolites with remarkable biological activities and have become an interesting research topic for cancer therapy. However, only few these been assessed their effectiveness against various in vitro models. Therefore, the aim present study was to assess effect extract Pseudevernia furfuracea (L.) Zopf (PSE) its metabolite physodic acid (Phy) on tumour microenvironment (TME) modulation, focusing epithelial-mesenchymal transition (EMT),...
Cladina arbuscula subsp. mitis grows on the surfaces of historical Cu-mine spoil heaps rich in Cu, as well substrata that are not metal contaminated. This lichen contains extracellular secondary metabolite, usnic acid (UA), which was previously found to form complexes with cations, including Cu. As UA can be experimentally removed from dry thalli using acetone and without loss viability, this study attempted evaluate its role long-term (8 wks) Cu tolerance C. mitis. Removal by did affect...