A5073220787- Prenatal Substance Exposure Effects
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Neonatal and fetal brain pathology
- Lysosomal Storage Disorders Research
- Receptor Mechanisms and Signaling
- Birth, Development, and Health
- Neuroendocrine regulation and behavior
- Advanced Neuroimaging Techniques and Applications
- Neurogenesis and neuroplasticity mechanisms
- Genetics and Neurodevelopmental Disorders
- Advanced MRI Techniques and Applications
- Anesthesia and Neurotoxicity Research
- Virus-based gene therapy research
- Nerve injury and regeneration
- Neuropeptides and Animal Physiology
- Cannabis and Cannabinoid Research
- Traumatic Brain Injury Research
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience of respiration and sleep
- Neurological disorders and treatments
- Autism Spectrum Disorder Research
- Ion channel regulation and function
- Traumatic Brain Injury and Neurovascular Disturbances
- Memory and Neural Mechanisms
Cornell University
2011-2024
Weill Cornell Medicine
2016-2024
Presbyterian Hospital
2005-2020
GTx (United States)
2019
Child Neurology Associates
2019
New York Hospital Queens
2005-2018
NewYork–Presbyterian Hospital
2006-2018
MIND Research Institute
2013-2016
Society for Neuroscience
2014
Women & Infants Hospital of Rhode Island
2013
Abstract Dynamic measurements of regional changes in cerebral blood volume (CBV) were performed rat models hypercarbia and focal neuronal activation using T 2 ‐weighted imaging after injection an intravascular contrast agent with a very long half‐life. Calculated percent CBV change during was consistent literature results from other non‐invasive modalities. Equivalent increases found spin‐ gradient‐echo images, suggesting proportional for capillaries small veins. During electrical...
Chronic treatment of rats with cocaine leads to long-term biochemical changes in the nucleus accumbens (NAc), a brain region implicated mediating reinforcing effects and other drugs abuse. Immediate early genes (IEGs) their protein products appear play an important role transducing extracellular stimuli into altered patterns cellular gene expression and, therefore, functioning. We therefore examined mRNA levels for IEGs c-fos, c-jun, fosB, junB, zif268 NAc treated acutely chronically...
Abstract The objective of the present study was to characterize morphology serotoninergic axons in cerebral cortex rat and determine whether dissimilar axon terminals arise from dorsal vs. median raphe nuclei. anterograde tracer PHA‐L administered by iontophoresis into (DR) (MR) nuclei, morphologic features respective axonal projections forebrain were analyzed. We have observed consistent structural differences between these two Anterogradely labeled which cells MR are characterized large,...
Late infantile neuronal ceroid lipofuscinosis (LINCL) is an autosomal recessive, neurodegenerative lysosomal storage disease affecting the CNS and fatal by age 8 to 12 years. A total average dose of 2.5 × 1012 particle units adeno-associated virus (AAV) serotype 2 vector expressing human CLN2 cDNA (AAV2CU hCLN2) was administered locations in 10 children with LINCL. In addition safety parameters, a neurological rating scale (primary variable) three quantitative magnetic resonance imaging...
Cerebral cavernous malformations (CCM) are congenital vascular anomalies of the brain that can cause significant neurological disabilities, including intractable seizures and hemorrhagic stroke. One locus for autosomal dominant CCM (CCM1) maps to chromosome 7q21–q22. Recombination events in linked family members define a critical region ∼2 Mb shared disease haplotype associated with presumed founder effect families Mexican-American descent points potentially smaller interest. Using genomic...
Antipsychotic drugs are monoamine receptor antagonists. However, the mechanisms by which these direct actions translated into therapeutic effects unknown. Candidate include receptor-mediated regulation of gene expression in target neurons. Inducible transcription factors, including certain immediate early genes (IEGs), may mediate between receptor-activated second messenger systems and involved differentiated functions We examined specificity induction IEGs c-fos zif268 after acute...
We have cloned cDNA encoding a human transcription factor that belongs to the MEF2 (myocyte-specific enhancer-binding 2) subfamily of MADS (MCM1-agamous-deficiens-serum response factor) gene family. This factor, which we named MEF2C, binds specifically element and activates via this element. Specific isoforms are found exclusively in brain robustly expressed by neurons cerebral cortex. In situ hybridization indicates is preferentially certain neuronal layers cortex expression declines during...
High-resolution magnetic resonance microscopy (MRM) was used to determine regional brain volumetric changes in a mouse model of Alzheimer's disease. These transgenic (Tg) mice overexpress human mutant amyloid precursor protein (APP) V717F under control platelet-derived growth factor promoter (PDAPP mice), and cortical hippocampal β-amyloid (Aβ) deposits accumulate heterozygotes after 8–10 mos. We MRM obtain 3D data on brains imaged their skulls define genotype- age-related changes....
The dynamic signal intensity changes at magnetic resonance (MR) imaging in active and chronic wallerian degeneration the corticospinal tract were evaluated. Forty-three patients with seen on MR images after cerebral infarction studied. When possible, acute stroke examined prospectively onset of symptoms then weekly intervals for several months. Focal without distal axonal is demonstrated 1st month following clinical symptoms. At 4 weeks, a well-defined band hypointense appears T2-weighted...
Gastrointestinal symptoms are a common feature in children with autism, drawing attention to potential association celiac disease or gluten sensitivity. However, studies date regarding the immune response autism and its have been inconsistent. The aim of this study was assess reactivity pediatric patients diagnosed according strict criteria evaluate link between disease.Study participants included (with without gastrointestinal symptoms) both Autism Diagnostic Observation Schedule (ADOS)...
Sponsored by the New York Academy of Sciences, Warren Alpert Medical School Brown University and Massachusetts Boston, “Behavioral Epigenetics” was held on October 29–30, 2010 at Boston Campus Center, Massachusetts. This meeting featured speakers panel discussions exploring emerging field behavioral epigenetics, from basic biochemical cellular mechanisms to epigenetic modulation normative development, developmental disorders, psychopathology. report provides an overview research presented...
Children and adolescents affected by prenatal exposure to alcohol who have brain damage that is manifested in functional impairments of neurocognition, self-regulation, adaptive functioning may most appropriately be diagnosed with neurobehavioral disorder associated exposure. This Special Article outlines clinical implications guidelines for pediatric medical home clinicians identify, diagnose, refer children regarding Emphasis given reported or observable behaviors can identified as part...
Late infantile neuronal ceroid lipofuscinosis (LINCL), a fatal, lysosomal storage disorder caused by mutations in the CLN2 gene, results deficiency of tripeptidyl-peptidase I (TPP-I) activity neurons. Our prior studies showed that delivery human cDNA directly to CNS, using an adeno-associated virus serotype 2 (AAV2) vector, is safe children with LINCL. As second-generation strategy, we have demonstrated AAVrh.10hCLN2, rhesus-derived AAV mediates wide distribution TPP-I through CNS murine...
Administration of an adeno-associated virus coding for the CLN2 gene into brain parenchyma slows progression disease in children.
Functional MRI of rat brain was performed at 2 Tesla following intravenous injection cocaine in order to 1) determine if changes CBV and BOLD signal were regionally coupled parenchyma, 2) compare the sensitivities these imaging methods across different structures. Percent relaxation rate spatially temporally during this graded activation. The use contrast agent increased functional sensitivity all parenchymal structures, with a strong but predictable dependence on resting-state blood volume...
Late infantile neuronal ceroid lipofuscinosis (LINCL) is associated with progressive degeneration of the brain and retina starting in early childhood.Thirty-two individual neurologic, ophthalmologic, CNS imaging (MRI MRS) assessments 18 children LINCL were analyzed. Disease severity was followed by two rating scales, one previously established but modified to solely assess exclude retinal disease (modified Hamburg scale), a newly developed scale, expanded evaluation impairment (Weill Cornell...
Between 10% and 15% of infants born in urban America today have been exposed to cocaine utero. Clinical studies suggested that impairment brain growth is the single best marker significant prenatal exposure, postnatal developmental compromise seen a subset affected children as consequence exposure. We developed an animal model, mice, exposure has allowed us dissociate direct effects altering fetal development from indirect associated with cocaine-induced malnutrition. find transplacental...
Abstract The morphology and laminar distribution of norepinephrine (NE) serotonin (5‐hydroxytryptamine, 5‐HT) axons in the primary visual cortex cynomolgus monkeys ( Macaca fascicularis ) have been analyzed by immunocytochemistry with antibodies directed against dopamine‐beta‐hydroxylase (DBH) 5‐HT. NE 5‐HT innervation (area 17) monkey exhibit highly differentiated patterns. Both these monoamine axonal systems form tangentially continuous bands that differ density, morphology, predominant...