A5100611363- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Advanced Neuroimaging Techniques and Applications
- Parkinson's Disease Mechanisms and Treatments
- Retinal Development and Disorders
- Protein Degradation and Inhibitors
- S100 Proteins and Annexins
- Cellular transport and secretion
- Hemoglobin structure and function
- Chemical Synthesis and Analysis
- CAR-T cell therapy research
- Context-Aware Activity Recognition Systems
- Chemical Synthesis and Reactions
- IoT-based Smart Home Systems
- Genetic Neurodegenerative Diseases
- Click Chemistry and Applications
- Phosphorus compounds and reactions
- Ubiquitin and proteasome pathways
- Carcinogens and Genotoxicity Assessment
- Liver Disease Diagnosis and Treatment
- Plant Reproductive Biology
- Synthesis and Reactivity of Heterocycles
- Oral and Maxillofacial Pathology
- Pharmacological Receptor Mechanisms and Effects
Cooper University Hospital
2024
University of Iowa
2023
University of Pennsylvania
2023
Massachusetts General Hospital
1990-2017
Harvard University
1993-1999
University of Saskatchewan
1985-1989
Saskatchewan Health
1985-1987
Antipsychotic drugs are monoamine receptor antagonists. However, the mechanisms by which these direct actions translated into therapeutic effects unknown. Candidate include receptor-mediated regulation of gene expression in target neurons. Inducible transcription factors, including certain immediate early genes (IEGs), may mediate between receptor-activated second messenger systems and involved differentiated functions We examined specificity induction IEGs c-fos zif268 after acute...
The proenkephalin gene is a well-studied model of transcription factor-target interaction in the nervous system and has been proposed as regulatory target protein product immediate-early c-fos. This mechanism proposed, part, because cAMP response element 2 (CRE-2) site, key DNA within second-messenger-inducible enhancer, avidly binds AP-1 proteins, including Fos, vitro. However, we observe dissociation time course activation c-fos mRNA rat striatum after administration dopamine D2 receptor...
Membrane depolarization is a critical component of neural signaling; in recent years there also has been great deal evidence that membrane can regulate gene expression. Therefore, excitatory neurotransmission may be an important mechanism plasticity. We have investigated the intracellular pathways and DNA regulatory elements through which activates expression encoding human proenkephalin. In PC12 C6-glioma cells, depolarization-induced transfected proenkephalin fusion was proportional to...
Abstract Temporal control of protein levels in cells and living animals can be used to improve our understanding function. In addition, engineered proteins could therapeutic applications. PRoteolysis-TArgeting Chimeras (PROTACs) have emerged as a small-molecule-driven strategy achieve rapid, post-translational regulation abundance via recruitment an E3 ligase the target interest. Here, we develop several PROTAC molecules by covalently linking antibiotic trimethoprim (TMP) pomalidomide,...
Abstract: Earlier experiments have shown that unilateral electrolytic lesions of the substantia nigra result in significant reductions rate accumulation rat striatal tryptamine. For elucidation type neuronal degeneration is associated with tryptamine depletion, effects intranigral injections 6‐hydroxydopamine or 5, 7‐dihydroxytryptamine, which would affect, respectively, dopamine‐ indoleamine‐containing neurons, been assessed. Nigral resulted an ipsilateral reduction tryptamine, but no...
This project introduces a wearable, non-intrusive device for snoring detection and remediation, designed to be placed under or alongside pillow. The uses sensors machine learning algorithms detect employs gentle vibrations prompt positional changes, thereby reducing episodes. is capable of connecting via an API cloud-based platform the analysis sleep patterns environmental context. paper details development from concept prototype, emphasizing technical challenges, solutions, alignment with...
N-But-3-enyl-α- and β-amino acids can be prepared by cleaving 1,3-oxazolidin-5-ones 1,3-oxazinan-6-ones in the presence of allylsilanes boron trifluoride etherate at room temperature good to excellent yields.