A5058727171- Radiomics and Machine Learning in Medical Imaging
- Pancreatic and Hepatic Oncology Research
- MRI in cancer diagnosis
- Urological Disorders and Treatments
- Cancer, Hypoxia, and Metabolism
- Medical Imaging Techniques and Applications
- Pediatric Urology and Nephrology Studies
- Nanoparticle-Based Drug Delivery
- Tissue Engineering and Regenerative Medicine
- Neuroendocrine Tumor Research Advances
- Radiopharmaceutical Chemistry and Applications
- Cancer Research and Treatments
- Pelvic floor disorders treatments
- Anorectal Disease Treatments and Outcomes
- Peptidase Inhibition and Analysis
- Radiology practices and education
- Neuroblastoma Research and Treatments
- Effects of Radiation Exposure
- Lung Cancer Treatments and Mutations
- Urinary Bladder and Prostate Research
- Hernia repair and management
- HER2/EGFR in Cancer Research
- Diversity and Career in Medicine
- Monoclonal and Polyclonal Antibodies Research
- Renal and related cancers
Massachusetts General Hospital
2014-2024
Harvard University
2012-2024
Athinoula A. Martinos Center for Biomedical Imaging
2015-2024
Research Network (United States)
2016-2023
Icahn School of Medicine at Mount Sinai
2022
Pomona Valley Hospital Medical Center
2021
Brown University
2021
Rhode Island Hospital
2021
Cleveland Clinic
2021
Cornell University
2021
Abstract Lorlatinib (PF-06463922) is a next-generation small-molecule inhibitor of the orphan receptor tyrosine kinase c-ros oncogene 1 (ROS1), which has domain that physiologically related to anaplastic lymphoma (ALK), and undergoing Phase I/II clinical trial investigations for non-small cell lung cancers. An early goal measure concentrations this drug in brain tumour lesions cancer patients, as penetration blood–brain barrier important optimal therapeutic outcomes. Here we prepare both 11...
Pancreatic ductal adenocarcinoma (PDAC) is an invasive and rapidly progressive malignancy. A major challenge in patient management the lack of a reliable imaging tool to monitor tumor response treatment. Tumor-associated fibrosis characterized by high type I collagen hallmark PDAC, further increases neoadjuvant chemoradiotherapy (CRT). We hypothesized that molecular positron emission tomography (PET) using collagen-specific probe,
Neuroendocrine tumors (NETs) are often diagnosed in advanced stages. Despite the advances treatment approaches, including somatostatin analogs and peptide receptor radionuclide therapy (PRRT), these patients have no curative option. Moreover, immunotherapy yields modest results NETs. We investigated whether combining PRRT using [<sup>177</sup>Lu]DOTATATE immune checkpoint inhibition improves response <b>Methods:</b> A gastroenteropancreatic NET model was generated by subcutaneous...
DNA is an organic molecule that highly vulnerable to chemical alterations and breaks caused by both internal external factors. Cells possess complex advanced mechanisms, including repair, damage tolerance, cell cycle checkpoints, death pathways, which together minimize the potentially harmful effects of damage. However, in cancer cells, normal tolerance response processes are disrupted or deregulated. This results increased mutagenesis genomic instability within a known driver progression...
This study aimed to investigate the feasibility of autologous muscle progenitor cell transplantation for anal sphincter regeneration in a rabbit model incontinence. We examined serial changes structure, with particular emphasis on histology and functional properties sphincter.External sphincterotomy was performed 21 rabbits; these rabbits were randomly assigned 2 groups. In group I (n = 9), cells isolated from quadriceps myofiber explants, labeled PKH-26, injected into 3 weeks after...
No AccessJournal of UrologyPediatric Urology1 Jun 2010Urinary and Serum Carbohydrate Antigen 19-9 as a Biomarker in Ureteropelvic Junction Obstruction Children Abdol-Mohammad Kajbafzadeh, Azadeh Elmi, Saman Shafaat Talab, Hamed Emami, Shadi Abdar Esfahani, Parisa Saeedi KajbafzadehAbdol-Mohammad Kajbafzadeh , ElmiAzadeh Elmi TalabSaman Talab EmamiHamed Emami EsfahaniShadi Esfahani SaeediParisa View All Author Informationhttps://doi.org/10.1016/j.juro.2010.02.031AboutFull TextPDF ToolsAdd to...
Abstract Purpose: Estrogen receptor (ER) targeting is key in management of receptor-positive breast cancer. Currently, there are no methods to optimize anti-ER therapy dosing. This study assesses the use 16α-18F-fluoroestradiol (18F-FES) PET for fulvestrant dose optimization a preclinical ER+ cancer model. Experimental Design: In vitro, 18F-FES retention was compared with ERα protein expression (ELISA) and ESR1 mRNA transcription (qPCR) MCF7 cells (ER+) after treatment different doses....
To compare positron emission tomography (PET)/magnetic resonance imaging (MRI) to the standard of care (SCI) for diagnosis peritoneal carcinomatosis (PC) in primary abdominopelvic malignancies.
Developing a noninvasive imaging method to detect immune system activation with high temporal resolution is key improving inflammatory bowel disease (IBD) management. In this study, granzyme B (GZMB), typically released from cytotoxic T and natural killer cells, was targeted using PET
To investigate indocyanine green (ICG) as a molecular beacon for malignant lesions within the liver and evaluate ability of developed handheld imaging system to allow measurement ICG fluorescence focal hepatic with high target-to-background ratios in mouse model.All animal experiments were approved by institutional care committee. A optical device was constructed pass through introducer needle standard percutaneous biopsy kit. An ex vivo phantom quantify tissue attenuation properties...
A major hurdle in osteoarthritis (OA) research is the lack of sensitive detection and monitoring methods. It hypothesized that proteases, such as matrix metalloproteinases (MMPs), are up-regulated early stages OA development. This study was undertaken to investigate if a near-infrared (NIR) fluorescent probe activated by MMPs could visualize vivo progression beginning disease. Using an MMP-activatable NIR (MMPSense 680), we assessed up-regulation MMP activity vitro incubating human...
Abstract Purpose Accurate diagnosis and staging of prostate cancer are crucial to improving patient care. Prostate-specific membrane antigen (PSMA)-targeted positron emission tomography with computed (PET/CT) imaging has demonstrated superiority for initial restaging in patients cancer. Referring physicians PET/CT readers must agree on a consistent communication method application information derived from this modality. While several guidelines have been published, single PSMA reporting...
No AccessJournal of UrologyPediatric Urology1 Nov 2011Safety, Efficacy and Health Related Quality Life Autologous Myoblast Transplantation for Treatment Urinary Incontinence in Children With Bladder Exstrophy-Epispadias Complex Azadeh Elmi, Abdol-Mohammad Kajbafzadeh, Ali Tourchi, Saman Shafaat Talab, Shadi Abdar Esfahani ElmiAzadeh Elmi More articles by this author , KajbafzadehAbdol-Mohammad Kajbafzadeh TourchiAli Tourchi TalabSaman Talab EsfahaniShadi View All Author...
Periostin, an extracellular matrix protein, plays key role in cell adhesion and motility within the tumor microenvironment is correlated with invasion. We developed characterized a PET tracer that specifically targets periostin evaluated probe preclinical models of esophageal squamous carcinoma (ESCC). <b>Methods:</b> The Institutional Animal Care Use Committee approved all animal studies. Antiperiostin-F(ab′)<sub>2</sub> was generated from monoclonal antibody by enzymatic digestion,...
Purpose: To assess optical imaging of Mesenchymal-Epithelial Transition factor (MET) for delineation and characterization intrahepatic models human hepatocellular carcinoma (HCC) metastatic colorectal cancer (CRC), thereby demonstrate its potential use in precision oncology. Materials Methods:MET expression CRC HCC was assessed tissue microarrays.We used GE-137, a modified cyanine 5-tagged peptide MET targeting.HepG2 Huh-7 HT-29 (CRC) cells with overexpression, LNCaP (negative control)...