A5070189271- Workplace Health and Well-being
- Osteoarthritis Treatment and Mechanisms
- Occupational Health and Safety Research
- Cytokine Signaling Pathways and Interactions
- Employment and Welfare Studies
- Musculoskeletal pain and rehabilitation
- Oral and Maxillofacial Pathology
- Infectious Diseases and Mycology
- Smoking Behavior and Cessation
- Cardiac, Anesthesia and Surgical Outcomes
- RNA Interference and Gene Delivery
- School Health and Nursing Education
- Growth Hormone and Insulin-like Growth Factors
- Inflammatory mediators and NSAID effects
- Geriatric Care and Nursing Homes
- RNA Research and Splicing
- Infections and bacterial resistance
- Signaling Pathways in Disease
- Mesenchymal stem cell research
- Machine Learning in Materials Science
- Microbial Natural Products and Biosynthesis
- Health and Well-being Studies
- RNA regulation and disease
- Behavioral Health and Interventions
- Protease and Inhibitor Mechanisms
University of Vermont
2019-2024
Tufts University
2013-2017
University of Michigan
1977-1994
New York State School of Industrial and Labor Relations
1990-1993
High throughput screening (HTS) is routinely used to identify bioactive small molecules. This requires physical compounds, which limits coverage of accessible chemical space. Computational approaches combined with vast on-demand libraries can access far greater space, provided that the predictive accuracy sufficient useful Through largest and most diverse virtual HTS campaign reported date, comprising 318 individual projects, we demonstrate our AtomNet® convolutional neural network...
Background. Worksite wellness programs vary considerably in their design. This study tested four models to compare effectiveness at controlling high blood pressure, obesity, and cigarette smoking. Methods. Baseline screening was conducted manufacturing plants. Site 1 offered only, with referral recommendations for those found have CVD risks. 2 also provided health education information classes. 3 added routine follow-up counseling a menu of intervention types, 4 social organization within...
Abstract Four methods for improving hypertension control among employees were tested in one manufacturing plant each: screening and referral to a physician but no other intervention; semiannual follow-up; more frequent follow-up as needed; on-site treatment or care by family physician. All significantly increased the proportion of subjects under treatment, only three programs offering improved adequacy control. At end years project, 56 62 per cent hypertensive these had blood-pressure...
The cost‐effectiveness of three types worksite wellness programs for reducing the cardiovascular disease risk factors employees was examined at manufacturing plants in terms their incremental costs and effectiveness over a comparison site that used simpler cheaper program design. risks targeted were hypertension, obesity, cigarette smoking, lack regular physical exercise. annual direct cost per employee post‐screening interventions $17.68 Site A (the offered health education classes), $39.28...
Findings are presented from a study to compare four types of worksite wellness programs reduce cardiovascular risks. Using quasi-experimental design, the was implemented in large manufacturing plants, similar demographic characteristics. At end three-year period, two sites that included individual outreach and counseling had engaged about 46 percent identified smokers 54 overweight into smoking cessation weight loss activities, respectively. This compares with fewer than 10 at site offering...
A major hurdle in osteoarthritis (OA) research is the lack of sensitive detection and monitoring methods. It hypothesized that proteases, such as matrix metalloproteinases (MMPs), are up-regulated early stages OA development. This study was undertaken to investigate if a near-infrared (NIR) fluorescent probe activated by MMPs could visualize vivo progression beginning disease. Using an MMP-activatable NIR (MMPSense 680), we assessed up-regulation MMP activity vitro incubating human...
Osteoarthritis (OA) is a widespread chronic joint disease characterized by articular cartilage destruction and accompanied pain disability. In this study, we found that the expression of Insulin-like Growth Factor II (IGF-II) was reduced in human OA patients as well murine experimental model destabilization medial meniscus (DMM). primary chondrocytes, ectopic lentiviral IGF-II inhibited pro-inflammatory cytokine IL-1β-induced NF-κB activation catabolic gene expression. Interestingly, did not...
Microbial biofilms are ubiquitous in drinking water systems, yet our understanding of lags behind those other environments. Here, a six-member model bacterial community was used to identify the interactions and individual contributions each species biofilm formation. These bacteria were isolated from International Space Station potable system include Cupriavidus metallidurans, Chryseobacterium gleum, Ralstonia insidiosa, pickettii, Methylorubrum (Methylobacterium) populi Sphingomonas...
Clients entering an employee assistance program (EAP) of a large manufacturing plant in 1985 who were assessed as having alcohol or drug abuse problem (N = 325) randomized into experimental "special follow-up" group and control "regular care" group. The regular care received follow-up only needed (following the usual practice EAP), while counselor was hired to make routine contacts with special Study intake continued through 1985, end 1986. Data collected on study subjects included EAP...
Abstract Wnt7a is a protein that plays critical role in skeletal development. However, its effect on cartilage homeostasis under pathological conditions not known. In this study, we found unique inverse correlation between gene expression and of MMP IL-1β individual human OA specimens. Upon ectopic primary articular chondrocytes, inhibited IL-1β-induced iNOS expression. Western blot analysis indicated induced both canonical Wnt signaling NFAT Akt non-canonical signaling. Interestingly,...
Reduction in the cost of health care claims among hypertensive employees was examined over a 4-year period after exposure to 3-year blood pressure control program, see whether work-site monitoring and counseling produced subsequent benefit. Hypertensive at three experimental sites (N = 183 367 subjects) were compared with subjects site 169) who had received no postscreening follow-up or monitoring, matched normotensive employees. The for lower than those site, but there significant...
The cost-effectiveness of work-site hypertension programs was examined at three manufacturing plants. A fourth plant used as a control site to estimate expected levels from screening without further intervention. annual cost per hypertensive employee the intervention $26.26 for semiannual follow-up, $35 full and $96.19 on-site treatment. Each resulted in an additional 1% employees maintained under control, dollar spent annually, with highest unit effectiveness being incurred free...
Information is presented from a multiplant study of interventions to improve cardio- vascular health among employees.Risk factors targeted were high blood pressure, obe- sity, and cigarette smoking.The utilized on-site wellness counselors who periodically contacted all employees identified through screening as having one or more the three risks.Use structured protocol for client outreach resulted in large majority clients being seen follow-up during three-year intervention period.Drawing...
Inflammation is a major player in the joint destruction process. Macrolide antibiotics have recently been found to novel anti-inflammatory function, but their effects on are unknown. Our objective was investigate effect of macrolide antibiotic erythromycin cartilage gene expression under inflammatory conditions as well pathology an vivo model.In our studies, mouse knee joints were injected with monosodium iodoacetate (MIA), chemical that inhibits glycolysis and causes inflammation matrix...
Participants in a 3-year study of hypertension control at four work sites were rescreened 4 years after discontinuation the protocols. At end period, employees that provided routine follow-up monitoring had shown significantly better levels blood pressure than initial screening and site did not provide follow–up monitoring. But services this was no longer true. The level experimental site, all would have been predicted for population aged by 7 years. Some 17.6% participants found to be...
Ralstonia insidiosa and Chryseobacterium gleum are bacterial species commonly found in potable water systems, these two contribute to the robustness of biofilm formation a model six-species community from International Space Station (ISS) system. Here, we set about characterizing interaction between ISS-derived strains examining extent which this extends other genera. The enhanced ISS
Discussion of alcohol-focused us. comprehensive programs leads to the conclusion that primary difference between two program models is not disease focus but structure. Programs focused on alcohol problems tend emphasize role supervisors in identification and confrontation; more broadly employee assistance program. Data relevant these issues suggest are no likely than others within industrial organizations identify employees having problems, although confrontation by a supervisor may have...
Abstract Health educators, medical personnel, and managers interested in worksite efforts to change health behaviors often face problems communicating effectively with rank file members of the workforce. This article describes an effective strategy for getting information flowing among industrial workforce changing behaviors. Identifying communication routes at a creating new ones, establishing relationships key carriers, making salient potential communicators are keys successful flow....
A hypertension program staffed largely by volunteer nurses in a hospital outpatient department is described. three-year evaluation shows 19% of 4,282 clients screened as having high readings, 86% those referred saw physician for blood pressure, 92% who began treatment pressure and 50% under were showing successful control or progress toward control.