A5046006749- Advanced Fluorescence Microscopy Techniques
- Hemostasis and retained surgical items
- Marine Sponges and Natural Products
- Venomous Animal Envenomation and Studies
- Single-cell and spatial transcriptomics
- Cell Image Analysis Techniques
- Connective tissue disorders research
- Proteoglycans and glycosaminoglycans research
- Marine Invertebrate Physiology and Ecology
- Photoacoustic and Ultrasonic Imaging
- Carcinogens and Genotoxicity Assessment
- DNA Repair Mechanisms
- Angiogenesis and VEGF in Cancer
- Effects of Radiation Exposure
- Advanced Electron Microscopy Techniques and Applications
- HER2/EGFR in Cancer Research
- Cell Adhesion Molecules Research
European Molecular Biology Laboratory
2023-2024
Kirchhoff (Germany)
2019
Heidelberg University
2019
A hallmark of animals is the coordination whole-body movement. Neurons and muscles are central to this, yet coordinated movements also exist in sponges that lack these cell types. Sponges sessile with a complex canal system for filter-feeding. They undergo resembling "contractions" lead closure water expulsion. Here, we combine live 3D optical coherence microscopy, pharmacology, functional proteomics elucidate sequence detail shape changes, tissues molecular physiology involved, control...
Cancer patients are increasingly treated with alpha-particle-emitting radiopharmaceuticals. At the subcellular level, alpha particles induce densely spaced ionizations and molecular damage. Induction of DNA lesions, especially clustered double-strand breaks (DSBs), threatens a cell's survival. Currently, it is under debate to what extent spatial topology damaged chromatin regions repair protein arrangements contributing.Super-resolution light microscopy (SMLM) in combination cluster analysis...
A hallmark of animals is the coordination whole-body movement. Neurons and muscles are central to this, yet coordinated movements also exist in sponges that lack these cell types. Sponges sessile with a complex canal system for filter-feeding. They undergo resembling “contractions” lead closure water expulsion. Here, we combine 3D optical coherence microscopy, pharmacology, functional proteomics elucidate anatomy, molecular physiology, control movements. We find them driven by relaxation...
Abstract Intravital two-photon microscopy has emerged as a powerful technology to study brain tumor biology and its temporal dynamics, including invasion, proliferation therapeutic resistance in the superficial layers of mouse cortex. However, intravital deeper cortical especially subcortical white matter, an important route glioblastoma invasion recurrence, not yet been feasible due low signal-to-noise ratios, missing spatiotemporal resolution inability delineate myelinated axonal tracts....
Abstract Glioblastoma is the most common primary brain tumor with a poor prognosis due to its aggressive invasiveness, inevitable recurrence, and therapy resistance. One hallmark of disease whole dissemination via preexisting structures like blood vessels or white matter tracts. While intravital glioblastoma imaging has been limited superficial cortical layers, we developed method three photon microscopy allowing investigation invasion colonization in up depth 1.2 mm over extended time...