A5086558385- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Neutropenia and Cancer Infections
- Health Systems, Economic Evaluations, Quality of Life
- Global Cancer Incidence and Screening
- Advanced Radiotherapy Techniques
- Hematological disorders and diagnostics
- Bacterial Identification and Susceptibility Testing
- Economic and Financial Impacts of Cancer
- Cancer survivorship and care
- Urinary Bladder and Prostate Research
- Bladder and Urothelial Cancer Treatments
- Patient-Provider Communication in Healthcare
- Clinical practice guidelines implementation
- Cancer, Lipids, and Metabolism
- Genital Health and Disease
- Ethics in Clinical Research
- Palliative Care and End-of-Life Issues
- Hormonal and reproductive studies
- Urologic and reproductive health conditions
- Healthcare Policy and Management
- Occupational and environmental lung diseases
- Statistical Methods in Clinical Trials
- Blood disorders and treatments
- Hepatocellular Carcinoma Treatment and Prognosis
ImmunityBio (United States)
2023
eHealth Africa
2022
Emory University
2021
Strang Cancer Prevention Institute
2018
Virginia Mason Memorial
2018
Mount Sinai Beth Israel
2014-2017
Icahn School of Medicine at Mount Sinai
2014-2016
Albert Einstein College of Medicine
2013-2014
Mount Sinai Health System
2014
Massachusetts General Hospital
2004-2013
PURPOSE: Febrile neutropenia remains a potentially life-threatening complication of anticancer chemotherapy, but some patients are at low risk for serious medical complications. The purpose this study was to develop an internationally validated scoring system identify these patients. MATERIALS AND METHODS: neutropenic cancer were observed in prospective multinational study. Independent factors assessable fever onset, predicting complications, on randomly selected derivation set, assigned...
The length of a polymorphic CAG repeat sequence, occurring in the androgen receptor gene, is inversely correlated with transcriptional activity by receptor. Because heightened androgenic stimulation may increase risk prostate cancer development and progression, we examined whether shorter repeats gene are related to higher cancer. We conducted nested case-control study 587 newly diagnosed cases detected between 1982 1995, 588 controls without cancer, within Physician’s Health Study. An...
The study was undertaken to validate a clinical model for predicting the medical risk of cancer patients with fever and neutropenia.A consecutive sample 444 neutropenia (granulocyte count less than 500/microL) at two hospitals, specialized referral center university-affiliated general hospital, studied identify characteristics in first 24 hours that predict subsequent serious complications during hospital stay. To control bias, major factors were subject blinded review.Serious occurred 34%...
• To determine whether cancer patients with fever and neutropenia differ in their medical stability, 261 records of 184 who were hospitalized treated conventional antibiotic therapy studied to presenting clinical characteristics influenced the likelihood subsequent events thought require urgent attention. Overall, serious complications, including those without an obvious relationship infection, occurred 56 patient courses (21%). We distinguished three clinically determined subgroups our...
Background: The age-adjusted rate of radical prostatectomy, the most common treatment early (nonmetastatic) prostate cancer, increased almost sixfold between 1984 and 1990. This increase was due in part to reported improvements postoperative sexual potency after use newly developed "nerve-sparing" procedures. However, published estimates from physicians impotence following various types prostatectomy may be low, since not all patients report treatment-related complications accurately...
PURPOSE To assess complications of therapy for early (nonmetastatic) prostate cancer. PATIENTS AND METHODS A prospective study a cohort 279 men who sought treatment advice and completed required pretreatment forms. The measures were self-reported patient symptoms other quality life before at 3 12 months afterward. RESULTS Bowel bladder uncommon pretreatment. Patients frequently reported irritative bowel after radiotherapy, although these subsided somewhat months. Substantial ("a lot")...
No AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 Nov 2003Organ Conservation in Invasive Bladder Cancer by Transurethral Resection, Chemotherapy and Radiation: Results a Urodynamic Quality Life Study on Long-term Survivors ANTHONY L. ZIETMAN, DIANNE SACCO, URI SKOWRONSKI, PABLO GOMERY, DONALD S. KAUFMAN, JACK A. CLARK, JAMES TALCOTT, WILLIAM U. SHIPLEY ZIETMANANTHONY ZIETMAN , SACCODIANNE SACCO SKOWRONSKIURI SKOWRONSKI GOMERYPABLO GOMERY KAUFMANDONALD KAUFMAN CLARKJACK CLARK...
PURPOSE To assess the feasibility of early discharge to home therapy with standard intravenous antibiotics in 30 patients fever and neutropenia at low risk by a validated clinical decision rule. PATIENTS AND METHODS Newly admitted outpatients were evaluated for during 2 days inpatient observation. evaluate enrolled patients' acceptance care, we assessed patient attitudes quality life before after therapy. economic effects, compared medical charges treated those medically eligible who...
Understanding the distinctive patterns of treatment-related dysfunction after alternative initial treatments for early prostate cancer (PC) may improve patients' choice treatment and later help them adjust to its consequences. We characterized time course complications while adjusting potentially confounding pretreatment factors hindering other observational studies.In a prospective cohort study 417 men we assessed urinary, bowel, sexual function from before primary 24 months after. To...
Purpose: Treatment for early prostate cancer produces problematic physical side effects, but prior studies have found little influence on patients’ perceived health status. We examined psychosocial outcomes of treatment cancer. Patients and Methods: with previously treated a reference group men normal prostate-specific antigen (PSA) level no history completed questionnaires. Innovative scales assessed behavioral consequences urinary dysfunction, sexuality, worry, PSA concern, control,...
PURPOSE To use data from a prospective quality-of-life study to assess differences in disease-specific and general health-related changes after treatment with different external-beam irradiation techniques for prostate cancer. PATIENTS AND METHODS Patients were divided into three groups based on their pretreatment field size planning technique: whole pelvis, small field, or conformal. Measures of bowel, urinary, sexual function global parameters (from the Health Survey Short Form [SF-36]...
Although it is the most powerful predictor of early prostate cancer treatment-related complications and quality-of-life (QOL) outcomes, studies do not stratify results by baseline function. Further, reporting functional outcomes as averaged numerical may obscure informatively disparate courses. Using levels dysfunction, we address these problems present final QOL our prospective cohort study patients with cancer.We created categories for sexual, bowel, urinary function, measured using scores...
Purpose To develop a clinical practice guideline for the management of men with metastatic, recurrent, or progressive carcinoma prostate. The focus this document is on use, combinations, and timing various forms androgen deprivation therapy (ADT) palliation androgen-sensitive disease. Methods An expert panel writing committee were formed. questions to be addressed by determined, systematic review literature was performed, which included search online databases, bibliographic review,...
We retrospectively compared the outcomes and costs of outpatient inpatient management low-risk outpatients who presented to an emergency department with febrile neutropenia (FN).A single episode FN was randomly chosen from each 712 consecutive, solid tumor had been treated prospectively on a clinical pathway (1997-2003). Their medical records were reviewed for overall success (resolution all signs symptoms infection without modification antibiotics, major complications, or intensive care...
PURPOSE Update all preceding ASCO guidelines on initial hormonal management of noncastrate advanced, recurrent, or metastatic prostate cancer. METHODS The Expert Panel based recommendations a systematic literature review. Recommendations were approved by the and Clinical Practice Guidelines Committee. RESULTS Four clinical practice guidelines, one endorsement, 19 reviews with without meta-analyses, 47 phase III randomized controlled trials, nine cohort studies, two review papers informed...
We determined long-term symptoms in patients after brachytherapy (radioactive seed implantation) for early (nonmetastatic) prostate cancer.We performed a cross-sectional survey of 105 (80% those contacted) men treated at least 2 years 9 months (median 5.2 years) previously with alone (72 patients) or plus external beam radiation therapy (33) pioneering referral center ultrasound guided brachytherapy.Median patient age was 70 treatment and 75 when surveyed. Bowel were uncommon (range 4% to...
Background. Compared with careful attention to the physical (eg, urinary, bowel, sexual) dysfunction that may follow treatment, little has been given behavioral, emotional, and interpersonal changes diagnosis of early prostate cancer subsequent bring. Objective. To construct patient-centered measures outcomes treatment for cancer. Research Design. Qualitative study followed by survey patients group comparable no history Analysis focus groups identified relevant domains quality life, which...
Increased radiation doses improve prostate cancer control but also increase toxicity to adjacent normal tissue. Proton may attenuate adverse effects.To determine long-term, patient-reported, dose-related toxicity.We performed a post hoc cross-sectional survey of surviving participants in the Radiation Oncology Group (PROG) 9509--a randomized trial comparing 70.2 Gy vs 79.2 combined photon and proton for 393 men with clinically localized (stage T1b-T2b, prostate-specific antigen <15 ng/mL, no...
Abstract BACKGROUND: Nonmedical factors may modify the biological risk of prostate cancer (PCa) and contribute to differential use early detection; curative care; and, ultimately, greater racial disparities in PCa mortality. In this study, authors examined patients' usual source care, continuity mistrust physicians their association with differences screening. METHODS: Study nurses conducted in‐home interviews 1031 African‐American men Caucasian‐American aged ≥50 years North Carolina...
Abstract BACKGROUND: Recent studies have suggested differing toxicity patterns for patients with prostate cancer who receive treatment 3‐dimensional conformal radiotherapy (3DCRT), intensity‐modulated (IMRT), or proton beam therapy (PBT). METHODS: The authors reviewed patient‐reported outcomes data collected prospectively using validated instruments that assessed bowel and urinary quality of life (QOL) localized received 3DCRT (n = 123), IMRT 153) PBT 95). Clinically meaningful differences...
Background. Patients' perceptions of treatment outcomes are important in the management early prostate cancer, but few studies have offered reliable and responsive measures to assess likely side effects most common treatments. Objective. To develop indexes urinary, bowel, sexual function, related distress. Research Design. Prospective cohort study for with self-administered questionnaires completed before treatment, 3 12 months afterward. Hypothesized indexes, based on a clinical model...