A5046800754- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Economic and Financial Impacts of Cancer
- Global Cancer Incidence and Screening
- Health Systems, Economic Evaluations, Quality of Life
- Cancer survivorship and care
- Colorectal Cancer Screening and Detection
- Childhood Cancer Survivors' Quality of Life
- Bladder and Urothelial Cancer Treatments
- Cancer Treatment and Pharmacology
- Patient-Provider Communication in Healthcare
- Palliative Care and End-of-Life Issues
- Healthcare Policy and Management
- Statistical Methods in Clinical Trials
- Family Support in Illness
- Multiple and Secondary Primary Cancers
- Frailty in Older Adults
- Breast Cancer Treatment Studies
- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Chemotherapy-induced cardiotoxicity and mitigation
- BRCA gene mutations in cancer
- Advanced Radiotherapy Techniques
- Colorectal Cancer Surgical Treatments
- Cancer-related cognitive impairment studies
Georgetown University
2015-2024
Georgetown University Medical Center
2015-2024
Georgetown Lombardi Comprehensive Cancer Center
2015-2024
Sidney Kimmel Comprehensive Cancer Center
2014-2021
National Cancer Institute
2003-2018
National Institutes of Health
1990-2018
National Human Genome Research Institute
2018
RTI International
2018
Fred Hutch Cancer Center
2000-2017
Northwestern University
2017
ContextPatients with prostate cancer and their physicians need knowledge of treatment options potential complications, but limited data on complications are available in unselected population-based cohorts patients.ObjectiveTo measure changes urinary sexual function men who have undergone radical prostatectomy for clinically localized cancer.DesignThe Prostate Cancer Outcomes Study, a longitudinal cohort study up to 24 months follow-up.SettingPopulation-based registries 6 geographic regions...
The purpose of this analysis was to compare long-term urinary, bowel, and sexual function after radical prostatectomy or external-beam radiation therapy.
The National Cancer Institute and the Health Care Financing Administration share a strong research interest in cancer costs, access to prevention treatment services, patient outcomes. To develop database for such research, two agencies have undertaken collaborative effort link Medicare Program data with Surveillance, Epidemiology, End Results (SEER) database. SEER is system of 9 population-based tumor registries that collect standardized clinical information on cases diagnosed separate,...
Men treated for clinically localized prostate cancer with either radical prostatectomy or external beam radiotherapy usually survive many years the side effects of these treatments. We present treatment-specific quality-of-life outcomes patients 5 after initial diagnosis.The cohort consisted men aged 55-74 who were newly diagnosed in 1994-1995 and (n = 901) 286). used clinical data previously collected at time diagnosis (i.e., baseline) 2-year follow-up to compare urinary, bowel, sexual...
To assess the reasons for dramatic surge in prostate cancer incidence from 1986 to 1991.Population-based study of rates and procedures used detect diagnose derived Medicare claims data National Cancer Institute's Surveillance, Epidemiology, End Results (SEER) program 1991.Four SEER areas (Connecticut; Atlanta, Ga; Detroit, Mich; Seattle--Puget Sound, Wash) covering approximately 6% US population.A 5% random sample male fee-for-service beneficiaries aged 65 years older without cancer, all men...
Prior studies of postoperative outcomes following radical prostatectomy have been limited by selection bias and short-term followup. In this study we assessed temporal changes in urinary sexual function up to 5 years a population based cohort.A sample 1,288 men with localized prostate cancer who underwent completed baseline survey within 6 12 months diagnosis were included the analysis. Two 5-year functional quality life data collected, as was information on use erectile aids. Temporal...
Background: Radical prostatectomy and external beam radiotherapy are the two major therapeutic options for treating clinically localized prostate cancer. Because survival is often favorable regardless of therapy, treatment decisions may depend on other therapy-specific health outcomes. In this study, we compared effects treatments urinary, bowel, sexual functions general health-related quality-of-life outcomes over a 2-year period following initial treatment. Methods: A diverse cohort...
Background: African-Americans have twice the risk of non-Hispanic whites for presenting with advanced-stage prostate cancer. To investigate reasons this difference, we evaluated association between race/ethnicity and cancer, adjusting demographic, socioeconomic, clinical, pathologic factors. Methods: A population-based cohort 3173 men diagnosed cancer October 1, 1994, 31, 1995, was analyzed. Medical record abstracts self-administered survey questionnaires were used to obain information...
In addition to demographic and health care-related characteristics, the age physiologic status of women at time breast cancer diagnosis have been reported influence receipt standard treatments. Previous studies comorbidity not examined whether other patient-, region-, or characteristics altered association with type treatment received.This study factors associated breast-conserving surgery radiation therapy, both which are recommended treatments for cancer, among a cohort 18,704 aged 65...
Although extensive resources go to cancer care, national population-based data on the costs of such care at patient level have been unavailable. Medicare payments subsequent diagnosis for elderly enrollees with five common cancers were estimated using tumor registry from Surveillance, Epidemiology, and End Results Program linked claims 1984 1990. The time between death was divided into four phases corresponding clinical course solid tumors, average each phase (including services not related...
Colon carcinoma is a common malignancy that accounts for substantial share of all cancer-related morbidity and mortality. However, little known with regard to general disease specific quality life in survivors colorectal carcinoma, particularly from community-based samples cases across stage survival times diagnosis.Subjects were recruited the National Cancer Institute's Surveillance, Epidemiology, End Results cancer registry. Subjects completed two self-administered surveys: Functional...
PURPOSE: Dissemination of efficacious adjuvant therapies for resectable colorectal cancer has not been comprehensively described. Trends, patterns, and outcomes therapy cancer, focusing on age, sex, racial/ethnic differences, are reported. MATERIALS AND METHODS: Population-based random samples patients diagnosed with in nine geographic areas were collected annually between 1987 1991 1995 (n = 4,706). Data obtained from medical record reviews. Multiple logistic regression was used to assess...
The National Cancer Institute (NCI) has funded the Care Outcomes Research and Surveillance (CanCORS) Consortium as centerpiece of NCI's ongoing initiative to improve cancer care. This commentary provides an introduction goals methods CanCORS broader community researchers clinicians, many whom are caring for patients participating in this study.
PURPOSE: To compare health-related quality-of-life outcomes after primary androgen deprivation (AD) therapy with orchiectomy versus luteinizing hormone-releasing hormone (LHRH) agonists for patients prostate cancer. PATIENTS AND METHODS: Men (n = 431) newly diagnosed all stages of cancer from six geographic regions who participated in the Prostate Cancer Outcomes Study and received AD but no other treatments within 12 months initial diagnosis were included a study health outcomes....
Radical prostatectomy is one of the most commonly used curative procedures for treatment localized prostate cancer. The probability that a patient will undergo additional cancer therapy after this procedure largely unknown. objective was to determine likelihood radical prostatectomy. Data study were derived from linked dataset combined information Surveillance, Epidemiology, and End Results Program Medicare hospital physician claims. Records included in if histories met following criteria: (...
The impact of cancer on health-related quality life (HRQOL) is poorly understood because the lack baseline HRQOL status before diagnosis. To our knowledge, this first population-based study to quantify nature and extent changes from after diagnosis for nine types patients compare their health with individuals without cancer. Surveillance, Epidemiology, End Results registry data were linked Medicare Health Outcomes Survey (MHOS) data; collected beneficiaries who aged 65 years older 1998...
Background: Because of the lack results from randomized clinical trials comparing efficacy aggressive therapies with that more conservative for clinically localized prostate cancer, men and their physicians may select treatments based on other criteria. We examined association sociodemographic characteristics four management options: radical prostatectomy, radiation therapy, hormonal watchful waiting. Methods: studied 3073 participants Prostate Cancer Outcomes Study diagnosed October 1,...