A5007768703- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Systemic Lupus Erythematosus Research
- Systemic Sclerosis and Related Diseases
- Ocular Diseases and Behçet’s Syndrome
- Retinopathy of Prematurity Studies
- Immunotherapy and Immune Responses
- interferon and immune responses
- Inflammasome and immune disorders
- Kruppel-like factors research
- Eicosanoids and Hypertension Pharmacology
- Electrospun Nanofibers in Biomedical Applications
- Rheumatoid Arthritis Research and Therapies
- Hormonal Regulation and Hypertension
- Tissue Engineering and Regenerative Medicine
- Cancer Treatment and Pharmacology
- Ocular Oncology and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Vasculitis and related conditions
- Spondyloarthritis Studies and Treatments
- Multiple Myeloma Research and Treatments
- Cancer therapeutics and mechanisms
- Wnt/β-catenin signaling in development and cancer
- Chemokine receptors and signaling
Yangzhou University
2024
Peking University
2018-2023
Juntendo University
2023
Saitama Medical University
2023
Shandong University
2023
Universidad de Málaga
2023
Peking University First Hospital
2018-2023
University of Miami
2019
Kyoto University
2011
Southwest Hospital
2005-2008
Background & Aims: Liver cancer stem cells (LCSCs) mediate therapeutic resistance and correlate with poor outcomes in patients hepatocellular carcinoma (HCC). Fibroblast growth factor (FGF)-19 is a crucial oncogenic driver gene HCC correlates prognosis. However, whether FGF19 signaling regulates the self-renewal of LCSCs unknown. Methods: were enriched by serum-free suspension. Self-renewal characterized sphere formation assay, clonogenicity sorafenib assay tumorigenic potential assays. Ca2+...
Abstract Purpose: Chemokine receptors are implicated in metastasis of several malignant tumors. This study was done to evaluate the contribution chemokine CXCR4 and CCR7 human nasopharyngeal carcinoma. Experimental Design: Reverse transcription-PCR, immunohistochemistry, flow cytometry were used mRNA protein expression carcinoma tumor tissues cell lines. Chemotaxis assays function cells. Antisense inhibit receptor block cells vivo athymic mice. Results: detected 31 40 primary 13 15 lymph...
Aim: Hypertension often coexists with insulin resistance. However, most metabolic effects of the antihypertensive agents have been investigated in nomotensive animals, which different conclusions may arise. We new angiotensin II type 1 receptor blocker azilsartan using obese Koletsky rats superimposed on background spontaneously hypertensive rats. Methods: Male were treated (2 mg/kg/day) over 3 weeks. Blood pressure was measured by tail-cuff. biochemical and hormonal parameters determined...
Purpose: The purpose of this study was to analyze the choroidal sublayer morphologic features in emmetropic and myopic children using an automatic segmentation model, explore relationship between sublayers spherical equivalent refraction (SER). Methods: We collected data on 92 healthy (92 eyes) from Ophthalmology Department Peking University First Hospital. were allocated three groups: emmetropia (+0.50 diopters [D] −0.50 D), low myopia (−0.75 D −3.00 moderate (−3.25 −5.75 D). performed...
Abstract Purpose To compare the morphological characteristics of nailfold capillaries in glaucoma patients with those healthy subjects. evaluate relationship capillary morphology retinal thickness and vessel density primary open‐angle (POAG) angle‐closure (PACG). Methods Fifty‐one normal‐tension glaucoma, thirty‐two hypertension PACG sixty‐one subjects were included this cross‐sectional study. Patients connective tissue diseases or taking anticoagulation antiplatelet agents excluded....
Idiopathic elevated episcleral venous pressure (IEEVP) or idiopathic dilated veins (IDEV) is a rare abnormality, and thus therapeutic treatment for this condition rarely discussed. We report case of patient with bilateral glaucoma secondary to IDEV whom intraocular pressures (IOPs) were controlled successfully by trabeculectomy. A 50 year-old female complaint persistent red eyes over 30 years, presented numerous tortuous engorged vessels in both (OU), open angles OU spontaneous blood...
We performed nailfold capillary microscopy to explore microvasculature abnormalities in uveitis overall and stratified various ways.This was a cross-sectional, case-control, observational study. One hundred seven patients 130 control subjects were included. used JH-1004 capillaroscope perform video on the fourth fifth digits of each subject's nondominant hand. Videos evaluated for hemorrhages, dilated loops > 25 µm, avascular zones 200 µm. Univariate analyses assessment case-control...
Glaucoma, an important cause of visual impairment in many countries, remains a common eye condition due to difficulties its early diagnosis. We analyzed the characteristics retinal arteries add valuable technology for helping normal tension glaucoma (NTG) diagnosis.This study included 51 patients with newly diagnosed NTG hemifield defects and 60 age-matched controls. Peripapillary arteriolar calibers (PRACs) photoed by non-mydriatic camera were measured using ImageJ two masked readers. also...
<h3>Background</h3> At present, specific immune targeted therapeutics including biologics and kinase inhibitors has made significant progress in Rheumatoid arthritis (RA). However, the irresponse to therapies some refractory RA patients suggests more attention should be paid on cell death pathways, such as pyroptosis. TNF-α is a proinflammatory cytokine that plays fundamental role pathogenesis of RA, which could induce pyroptosis monocytes macrophages cause destruction bone cartilage....
Background: Granulocytic sarcoma (GS) is rare as an isolated presentation of relapse after allogeneic hematopoietic stem-cell transplantation (allo-HSCT), particularly in adult patients with acute myelogenous leukemia (AML). We report here the case a 37-year-old man who developed GS retro-orbital manifestation AML 27 months allo-HSCT. Case report: A was diagnosed and subsequently received allo-HSCT clinical chemical remission. The patient suddenly presented painless exophthalmos left eye...
Abstract Backgroud Glaucoma, an important cause of visual impairment in many countries, remains a common eye condition due to difficulties its early diagnosis. We analyzed the characteristics retinal arteries add valuable technology for helping normal tension glaucoma (NTG) Methods This study included 51 patients with newly diagnosed NTG hemifield defects and 60 age-matched controls. Peripapillary arteriolar calibers (PRACs) photoed by non-mydriatic camera were measured using ImageJ two...
Abstract Background Glaucoma, an important cause of visual impairment in many countries, remains a common eye condition due to difficulties its early diagnosis. We analyzed the characteristics retinal arteries add valuable technology for helping normal tension glaucoma (NTG) Methods This study included 51 patients with newly diagnosed NTG hemifield defects and 60 age-matched controls. Peripapillary arteriolar calibers (PRACs) photoed by non-mydriatic camera were measured using ImageJ two...
Abstract Background Glaucoma, an important cause of visual impairment in many countries, remains a common eye condition due to difficulties its early diagnosis. We analyzed the characteristics retinal arteries add valuable technology for helping normal tension glaucoma (NTG) Methods This study included 51 patients with newly diagnosed NTG hemifield defects and 60 age-matched controls. Peripapillary arteriolar calibers (PRACs) photoed by non-mydriatic camera were measured using ImageJ two...
Abstract Background Glaucoma, an important cause of visual impairment in many countries, remains a common eye condition due to difficulties its early diagnosis. We analyzed the characteristics retinal arteries add valuable technology for helping normal tension glaucoma (NTG) Methods This study included 51 patients with newly diagnosed NTG hemifield defects and 60 age-matched controls. Peripapillary arteriolar calibers (PRACs) photoed by non-mydriatic camera were measured using ImageJ two...