A5101833855- Clinical Laboratory Practices and Quality Control
- Biosimilars and Bioanalytical Methods
- Traditional Chinese Medicine Studies
- Statistical Methods in Clinical Trials
- Meta-analysis and systematic reviews
- Immune Response and Inflammation
- Fluorine in Organic Chemistry
- Carbohydrate Chemistry and Synthesis
- Multiple Myeloma Research and Treatments
- Reliability and Agreement in Measurement
- Synthesis and Catalytic Reactions
- Renal function and acid-base balance
- Potassium and Related Disorders
- Synthetic Organic Chemistry Methods
- Mesenchymal stem cell research
- Cancer-related molecular mechanisms research
- Cytokine Signaling Pathways and Interactions
- Heparin-Induced Thrombocytopenia and Thrombosis
- Phosphorus compounds and reactions
- Synthesis of β-Lactam Compounds
- Cardiovascular Health and Risk Factors
- Machine Learning in Healthcare
- Data-Driven Disease Surveillance
- Electrical and Bioimpedance Tomography
- Bioactive natural compounds
Beijing Chaoyang Emergency Medical Center
2025
Capital Medical University
2018-2025
Beijing Chao-Yang Hospital
2018-2024
Hainan Medical University
2019-2023
Xinqiao Hospital
2019
Army Medical University
2019
Zhejiang Sci-Tech University
2019
Jining First People's Hospital
2018
Shanghai Institute of Pharmaceutical Industry
2011-2017
Peking Union Medical College Hospital
2014
Bromocriptine, the most commonly used dopamine (DA) receptor agonists for prolactinoma, can effectively reduce tumor size of but mechanism was not fully understood. Apoptosis had been well-recognized to contribute mass regression caused by bromocriptine. However, whether other types non-apoptotic cell death involved in bromocriptine-induced prolactinoma shrinkage clarified. The newly discovered molecular necroptosis provides possibility examine this programmed necrosis pharmacological...
BACKGROUND Chondrocyte apoptosis and catabolism are 2 major factors that contribute to the progression of osteoarthritis (OA). Loganin, an iridoid glycoside present in several herbs, including Flos lonicerae, Cornus mas L, Strychnos nux vomica, is a valuable medication with anti-inflammatory anti-apoptotic effects. Our study examines these effects explores potential benefits loganin OA treatment. MATERIAL AND METHODS To clarify roles its specific signaling pathway, chondrocytes were...
Abstract This study aimed to investigate the effects of ginsenoside Rh2 on proliferation, apoptosis, and migration human medulloblastoma cell line Daoy, as well explore potential mechanisms effects. The Daoy was cultured in vitro treated with or without Rh2. CCK‐8 assay performed effect survival using a counting Kit‐8. Cell proliferation assessed by BrdU assay. apoptosis determined flow cytometry analysis. detected modified two‐chamber MiR‐31 mimic NC control were transfected into cells...
Background The measurement of cardiac troponin is crucial in the diagnosis myocardial infarction. performance most conveniently monitored by external quality assessment (EQA) programs. commutability EQA samples often unknown and effectiveness programs limited. Methods Commutability possible materials was evaluated. Commercial control used an program, human serum pools prepared from patient samples, purified analyte preparations, swine sera model animals a set were measured for cTnI with 4...
Anterior cruciate ligament (ACL) injury is recognized as a risk factor for osteoarthritis (OA) progression. Herein, the function of TAF15 in ACL injury-induced OA was investigated.OA cell model and mouse were established by interleukin-1 beta (IL-1β) stimulation transection administration, respectively. The pathological changes analyzed histopathology. mRNA protein expressions assessed using qRT-PCR, Western blot IHC. Chondrocyte viability apoptosis examined CCK8 assay TUNEL staining,...
An efficient and scalable process for the synthesis of antihypercholesterolemic drug ezetimibe through chiral Evans auxiliary (S)-4-phenyl-2-oxazolidinone is described. The key steps in this are condensation (S)-3-(5-(4-fluorophenyl)-5,5-dimethoxypentanoyl)-4-phenyloxazolidin-2-one N-(4-((tert-butyldimethylsilyl)oxy)benzylidene)-4-fluoroaniline, stereoselective reduction ezetimibe-ketone with NaBH4/I2, which first applied ezetimibe. concise, mild, easy to operate, highly (99.6% de value...
Fracture is the most frequently encountered traumatic large-organ injury observed in human patients. Cordycepin possesses beneficial effects osteogenesis of mesenchymal stem cells (MSCs), but its effect on fracture healing largely unknown. A rat model closed femur was established, and treated with therapy using bone marrow-derived MSCs (BMMSCs). The cordycepin osteogenic process BMMSCs vitro evaluated by Alizarin Red S (ARS) staining expressions marker genes. Radiographic evaluations...
Abstract Objectives The aim of this study was to assess the commutability three external quality assessment (EQA) materials for point‐of‐care (POC) glucose testing using two approaches, identify suitable EQA evaluate and monitor POC testing. Methods Commercial control (CCMs), pooled human serum samples (PHSs), homemade whole‐blood (HWBs) were measured along with 33 individual clinical five instruments a Hitachi 7600 analyzer. Data analyzed by Deming regression analysis 95% prediction...
- Reliable quantification of α-fetoprotein (AFP) is critical for clinical diagnosis. Accuracy in AFP analysis relies on traceability to reference materials with confirmed commutability.- To assess the commutability AFP. We screened appropriate calibration and application an external quality assessment scheme. The feasibility using water dilute a material from World Health Organization was also evaluated.- Patient serum samples various levels were randomly interspersed among Organization,...
ERM-DA474/IFCC has been used as a reference material for C-reactive protein (CRP) since 2012. However, the commutabilities and capacity harmonizing CRP results of its dilutions have not yet reported. In this study, we aimed to evaluate harmonization using commutable ERM-DA474/IFCC.Twenty-one serum samples were collected split into five vials. The then analyzed popular assays (Siemens BN II, Beckman Immage 800, Roche, Diasys, Leadman). four healthy human containing low levels also described...
We aimed to identify crucial genes relevant the development of consecutive trauma-induced sepsis. A microarray dataset was used differentially expressed between peripheral blood samples from traumatized patients complicated with sepsis and not The GSE12624 obtained Gene Expression Omnibus, containing 34 by 36 controls. (DEGs) were identified using Linear Models for Microarray Data package. Then, gene ontology (GO) enrichment analysis DEGs performed Onto-Express. Subsequently, protein–protein...
A concise and practical stereoselective synthesis of ipragliflozin L-proline was presented starting from 2-[(5-iodo-2-fluorophenyl)methyl]-1-benzothiophene 2,3,4,6-tetra-O-pivaloyl-α-D-glucopyranosyl bromide without catalyst via iodine-lithium-zinc exchange. The overall yield 52% in three steps the product purity excellent. Two key diastereomers were prepared with efficient direct access to α-C-arylglucoside.
Abstract Background: Measurement uncertainty (MU) is a parameter associated with the result of measurement that characterizes its dispersion. We report results for estimating MU following application top-down procedure using only proficiency test data to establish levels various analytes. Methods: Data were obtained from 142 laboratories participating in Beijing Center Clinical Laboratory (BCCL) testing/external quality assessment (PT/EQA) schemes. The 24-month study included six selected PT...
Background This study aimed to assess the comparability among assays using freshly frozen human sera and external quality assessment (EQA) data in China. Methods Twenty-nine serum samples two commercial EQA materials, obtained from National Center for Clinical Laboratories (NCCL), were analyzed triplicate eight routine TSH assays. The commutability of materials (NCCL materials) was evaluated accordance with CLSI EP30-A IFCC bias analysis. Median values NCCL used determine systematic...
Primary laboratory tests performed in the diagnosis of multiple myeloma (MM) include bone marrow examination and free light chain assay; however, these may only be ordered after clinical suspicion disease. In contrast, routine blood test results are readily available.Machine learning algorithms (ML) combined with were used to detect MM. Feature selection was achieve improved classification performance. The robustness models assessed an internal external validation data set. To minimize...
This study aimed to assess the commutability of frozen pooled human serum (PHS), high concentration Immunoglobulin M (IgM) pure diluted materials (HPDM), commercialized (CPM), and dilutions ERM-DA470k/IFCC in IgM detection using CLSI IFCC approaches, support standardization or harmonization measurement.Twenty-four samples, relevant reference (PHS, HPDM, CPM), different were analyzed triplicate six routine methods. The was carried out following EP30-A bias analysis.According approach, low,...
A stereoselective or exclusive approach to a series of ethyl (<i>Z</i>)-2-(2-substituted-thiazol-4-yl)pent-2-enoates from (<i>E</i>/<i>Z</i>)-2-(2-bromoacetyl)pent-2-enoate and thioureas thioamides was reported in good yields. This involves quaternary carbon stereocontrolled <i>cis</i>-configuration formation, opportunely blocking potential <i>E</i>/<i>Z</i> isomerization. The practical applicability highlighted by the synthesis...
Immunoglobulins are affected by sex, age and region, so it is necessary to establish suitable reference intervals (RIs) for clinical diagnosis. Various statistical methods were used calculate RIs, but there has been a lack of comparison among the methods. Research based on immunoglobulin RIs establishment with various would provide methodological basis further research. A total 16,525 individuals enrolled in study. Individuals selected medical examination center First Hospital Jilin...
Recent studies from targeted and untargeted metabolomics have consistently revealed that diet-related metabolites, including carnitine (C0), several species of acylcarnitines (AcyCNs), amino acids, ceramides, lysophosphatidylcholines (LPCs) may serve as potential multiple myeloma (MM) biomarkers. However, most these approaches had some intrinsic limitations, namely low reproducibility compromising the accuracy results.This study developed validated a precise, efficient, reliable liquid...